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Cat. No.	Product Name	Target	Signaling Pathways
T9331	Bemnifosbuvir hemisulfate AT-527	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Bemnifosbuvir hemisulfate (AT-527) 是一种 HCV 病毒复制抑制剂。
T14852	C527	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	C527 是一种泛 DUB 酶抑制剂，对 USP1/UAF1 复合物具有高效力，IC50值为0.88 μM。
T15263	Selisistat R-enantiomer EX-527 (R-enantiomer)	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Selisistat R-enantiomer (EX-527 (R-enantiomer)) 是 Selisistat R 型对映体。Selisistat 是SIRT1的选择性抑制剂，IC50为98 nM。
T35579	PKSI-527
	PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 μM, respectively). PKSI-527 reduces bradykinin generation induced by kaolin and λ-carrageenan ex vivo in human plasma. It also prolongs partial thromboplastin and euglobulin clot lysis times. In vivo, PKSI-527 (300 mg/kg per day) reduces hyperplasia, pannus formation, and infiltration of in...
T39095	AT-9010 tetrasodium
	AT-9010 tetrasodium is a triphosphate active metabolite derived from AT-527. It acts as a potent inhibitor of NiRAN, a crucial function for viral replication. Furthermore, AT-9010 tetrasodium demonstrates its ability to effectively inhibit the replication of SARS-CoV-2.
T40277	AT-9010 triethylamine
	AT-9010 triethylamine, a triphosphate active metabolite of AT-527, is a potent inhibitor of the NiRAN enzyme, which is essential for viral replication. It effectively inhibits SARS-CoV-2 replication.
T38660	AT-9010
	AT-9010, a triphosphate derivative of AT-527, exhibits strong inhibitory activity against NiRAN, a crucial viral replication function. This compound effectively suppresses the replication of SARS-CoV-2.
T37904	Gadoleic Acid
	Gadoleic acid is a monounsaturated fatty acid.1,2It inhibits the dsDNA binding activity of p53 when used at a concentration of 1.2 nM.1Hepatic levels of gadoleic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet and increased in rats fed a high-cholesterol diet.2 1.Iijima, H., Kasai, N., Chiku, H., et al.The inhibitory action of long-chain fatty acids on the DNA binding activity of p53Lipids41(6)521-527(2006) 2.Serviddio, G., Bellanti, F., Villani, R., et al.Effects of ...

化合物

Bemnifosbuvir hemisulfate

Cat.No: T9331

Synonym: AT-527

Target: HCV Protease, SARS-CoV

Cat.No: T14852

Target: DUB

Selisistat R-enantiomer

Cat.No: T15263

Synonym: EX-527 (R-enantiomer)

Target: Sirtuin

Cat.No: T35579

AT-9010 tetrasodium

Cat.No: T39095

AT-9010 triethylamine

Cat.No: T40277

Cat.No: T38660

Cat.No: T37904

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