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Cat. No.	Product Name	Target	Signaling Pathways
T9697	ASK1-IN-1	ASK	Apoptosis
	ASK1-IN-1 是一种凋亡信号调节激酶 1（SK1）抑制剂，具有良好的效价 (细胞IC50=138 nM; BiochemicalIC50=21 nM)。ASK1-IN-1具有中枢神经系统渗透性。
T9377	ASK1-IN-2	Apoptosis; ASK; MAPK	Apoptosis; MAPK
	ASK1-IN-2 是一种口服有活性的凋亡信号调节激酶 1 抑制剂(IC50:32.8 nM)。它可用于研究溃疡性结肠炎。
T67857	ASK1-IN-4	ASK	Apoptosis
	ASK1-IN-4 是一种ASK1抑制剂，IC50 = 0.2 μM。
T61584	ASK1-IN-3
	ASK1-IN-3 is a highly potent and selective inhibitor of ASK1 kinase, demonstrating an IC 50 of 33.8 nM. This compound also exhibits inhibitory effects on various cell cycle regulating kinases. ASK1-IN-3 showcases remarkable induction of apoptosis in HepG2 cancer cells and displays potent activity in arresting the cell cycle [1].
T13099	TC ASK 10	ASK; MAPK	Apoptosis; MAPK
	TC ASK 10 是选择性的，口服有效的细胞凋亡信号调节激酶 1 抑制剂，IC50为 14 nM。它对其他代表性激酶的抑制活性低于 50％，除 ASK2之外 (IC50为 0.51 μM)。
T35897	ASK120067
	ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]. In the in vitro kinase assay ASK120067 potently inhibits the EGFR L858R/T790M and EGFR T790M resistant mutants with IC50 values of 0.3 nM and 0.5 nM, respectively, as well as the EGFRexon19del sensitizing mutant (IC50= 0.5 nM). The 50 of ASK120067 against wild-type EGFR (EGFRWT...
T33514	MSC 2032964A MSC-2032964A,MSC2032964A	ASK	Apoptosis
	MSC 2032964A 是一种有效的选择性 ASK1 抑制剂 (IC50 = 93 nM)，具有口服生物利用度和脑渗透性。它在小鼠 EAE 模型中抑制神经炎症，并在培养的小鼠星形胶质细胞中阻断 LPS 诱导的 ASK1 和 p38 磷酸化。
T5190	GS-444217 GS 444217,GS444217	Apoptosis; ASK; MAPK	Apoptosis; MAPK
	GS-444217 是一种可口服的选择性 ATP 竞争性凋亡信号调节激酶 1 抑制剂，IC50为 2.87 nM。
T3101	NQDI-1 NQDI1,NQDI 1	Apoptosis; ASK; MAPK	Apoptosis; MAPK
	NQDI-1 (NQDI 1) 是一种凋亡信号调节激酶 1 抑制剂，Ki 为 500 nM，IC50为 3 μM。
T3350	Selonsertib GS-4997	Apoptosis; ASK; MAPK	Apoptosis; MAPK
	Selonsertib (GS-4997) 是一种选择性的，具有生物口服可利用的凋亡信号调节激酶1 抑制剂，pIC50为 8.3。它具有潜在的抗炎、抗肿瘤和抗纤维化活性。
T70893	K811
	K811 is an ASK1-specific inhibitor that prolongs survival in a mouse model of amyotrophic lateral sclerosis. K811 efficiently prevented cell proliferation in cell lines with high ASK1 expression and in HER2-overexpressing GC cells. Treatment with K811 reduced sizes of xenograft tumors by downregulating proliferation markers.
T70892	K812
	K812 is an ASK1-specific inhibitor discovered to prolong survival in a mouse model of amyotrophic lateral sclerosis.
T68430	BPyO-34
	BPyO-34 is a novel apoptosis signal-regulating kinase 1 (ASK1) inhibitor with IC50 of 0.52μM in vitro in kinase assay.
T73460	DDO3711
	DDO3711是通过化学接头将ASK1 (小分子凋亡信号调节激酶1) 抑制剂与PP5 (磷酸酶) 激活剂连接，形成特定于招募PP5的磷酸酶募集嵌合体(PHORC)。该化合物特异性地抑制ASK1 (IC50=164.1 nM)，而对ASK2 (IC50>20 μM)无影响。通过募集PP5，DDO3711显著促进p-ASK1T838的去磷酸化，表现出ASK1依赖性的抗增殖活性，显示其抗癌潜力并可用于研究异常磷酸化癌蛋白。
T70622	Selonsertib HCl
	Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis ...
TP2127	R18
	Antagonist of 14.3.3 proteins (KD ≈80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation. Blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S.
T36610	(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine
	(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities. It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM). CSTMP reduces hydrogen peroxide-induced release of lactate dehydrogenase (LDH) in and increases viability of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner via inhibition of apoptosis. It reverses hydrogen peroxide-induced release of malondialdehyde ...

化合物

Cat.No: T9697

Target: ASK

Cat.No: T9377

Target: Apoptosis, ASK, MAPK

Cat.No: T67857

Target: ASK

Cat.No: T61584

Cat.No: T13099

Target: ASK, MAPK

Cat.No: T35897

Cat.No: T33514

Synonym: MSC-2032964A,MSC2032964A

Target: ASK

Cat.No: T5190

Synonym: GS 444217,GS444217

Target: Apoptosis, ASK, MAPK

Cat.No: T3101

Synonym: NQDI1,NQDI 1

Target: Apoptosis, ASK, MAPK

Cat.No: T3350

Synonym: GS-4997

Target: Apoptosis, ASK, MAPK

Cat.No: T70893

Cat.No: T70892

Cat.No: T68430

Cat.No: T73460

Selonsertib HCl

Cat.No: T70622

Cat.No: TP2127

(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine

Cat.No: T36610

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