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Search Results for " arp1 "

Targets Recommended: PARP

26

抑制剂 & 化合物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T73007	PARP10-IN-2	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP10-IN-2 是一种有效的单-ADP-核糖基转移酶 PARP10 抑制剂，对人 PARP10 的 IC50 值为 3.64 μM。PARP10-IN-2 对 PARP2 和 PARP15也具有抑制作用， IC50 分别为 27 μM 和 11 μM。
T9610	PARP1-IN-5 dihydrochloride	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP1-IN-5 dihydrochloride 是一种具有口服活性的有效选择性 PARP-1 抑制剂 (IC50 =14.7 nM)。它可用于癌症的研究。
T72553	ARTD10/PARP10-IN-1	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	ARTD10/PARP10-IN-1 是一种强效性的 PARP 抑制剂，抑制单 ADP 核糖转移酶 ARTD7/PARP15，ARTD8/PARP14，ARTD10/PARP10 和聚 ADP-核糖聚合酶-1 (ARTD1/PARP1)，具有潜在的抗癌抗肿瘤活性，可用于研究前列腺癌和乳腺癌。
T67932	PARP10-IN-3	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP10-IN-3 是一种有效且具有选择性的单-ADP-核糖基转移酶 PARP10 抑制剂，对人 PARP10 具有抑制作用（ IC50 ：480 nM）。PARP10-IN-3 对人 PARP2 和人 PARP15也具有抑制作用， IC50 值都是 1.7 μM。
T9891	PARP1-IN-8 N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) 是PARP1的有效抑制剂（IC50 = 97 nM）。
T72437	PARP1/2/TNKS1/2-IN-1	Apoptosis; PARP; Wnt/beta-catenin	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
	PARP1/2/TNKS1/2-IN-1 是一种多靶点抑制剂，抑制 PARP-1、PARP-2、TNKS1 和 TNKS2 。PARP1/2/TNKS1/2-IN-1 具有潜在的抗肿瘤活性，可诱导细胞凋亡。
T62955	PARP1-IN-5
	PARP1-IN-5 是一种有效的、选择性的、口服具有活力的、低毒的 PARP-1 抑制剂，其 IC50 值为 14.7 nM。PARP1-IN-5 能够用于研究癌症。
T79593	PARP1-IN-14	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP1-IN-14 (compound 19k) 为高效PARP1抑制剂，IC50值为0.6 ± 0.1 nM。此化合物对MDA-MB-436 (BRCA1−/−) 及Capan-1 (BRCA2−/−) 细胞线展现出显著的抗增殖效应，IC50低至0.3 nM以下。
T73023	PARP1-IN-12
	PARP1-IN-12 是一种有效的PARP1抑制剂，其IC50值为 2.99 nM。PARP1-IN-12 具有较好的抗癌细胞增殖活性，可诱导细胞凋亡并使细胞周期停滞在 G2/M 期。PARP1-IN-12 能在BRCA 缺陷的细胞中诱导 DNA 双链断裂 (DSBs)。
T61325	PARP1-IN-9
	PARP1-IN-9 (Compound 5c) is a potent PARP1 inhibitor, displaying an IC 50 of 30.51 nM. With its ability to induce cell apoptosis and exhibit anticancer activity, PARP1-IN-9 surpasses Olaparib in terms of efficacy [1].
T81543	PARP1-IN-17	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP1-IN-17为一种选择性PARP-1抑制剂，其针对PARP-1的IC50为19.24 nM ，对PARP-2的IC50为32.58 nM ，能够有效诱导(apoptosis)。此外，PARP1-IN-17显示出优秀的抗增殖作用。
T63471	PARP1/BRD4-IN-1
	PARP1/BRD4-IN-1 是高度选择性的 PARP1(IC50: 49 nM)和BRD4(IC50: 202 nM)的有效抑制剂。PARP1/BRD4-IN-1 能够抑制 PARP1 和 BRD4 的表达与活性，进而协同抑制胰腺癌细胞的恶性生长。
T60637	PARP1-IN-11
	PARP1-IN-11 (compound 49) 是一种有效的 PARP1抑制剂，其 IC50值为 0.082 μM，可完全抑制 PARP1，并显著抑制 PARP3、TNKS1 和 TNKS2。
T60309	PARP10/15-IN-3
	PARP10/15-IN-3 (Compound 8a) 是一种有效的PARP10和PARP15双重抑制剂，对 PARP10 和 PARP15 的IC50值分别为 0.14 μM 和 0.40 μM。PARP10/15-IN-3 可以进入细胞并使细胞免于凋亡 (apoptosis)。
T60495	PARP10/15-IN-1
	PARP10/15-IN-1 (化合物 8l) 是PARP10和PARP15的有效的双重抑制剂，其IC50值分别为 160 nM 和 370 nM，用于癌症领域的研究。
T61879	PARP1-IN-7
	PARP1-IN-7 是一种聚 ADP 核糖聚合酶-1（PARP1）的抑制剂，作为抗癌剂。
T62540	PARP1/BRD4-IN-2
	PARP1/BRD4-IN-2 是一种有效的、选择性的 PARP1 (IC50: 197 nM) 和 BRD4 (IC50: 238 nM) 抑制剂。PARP1/BRD4-IN-2 能够抑制 DNA 损伤修复，阻滞 G0/G1 细胞周期转变，诱导细胞凋亡 (apoptosis)。PARP1/BRD4-IN-2 对 MDA-MB-468 小鼠异种移植瘤模型表现出抗肿瘤效果。PARP1/BRD4-IN-2 能够用于研究三阴性乳腺癌 (TNBC)。
T39139	PARP1-IN-6 PARP1-IN-6
	PARP1-IN-6 is a dual tubulin/PARP-1 inhibitor with IC 50 values of 0.94 and 0.48 μM, respectively.
T72397	PARP11 inhibitor ITK7 ITK7
	PARP11 inhibitor ITK7 (ITK7) 为高效选择性的PARP11抑制剂，IC50为14 nM，主要用于针对PARP11的细胞定位研究。
T61694	PARP1-IN-10
	PARP1-IN-10 (compound 12c) is a highly potent and non-cytotoxic PARP1 inhibitor, displaying an in vitro IC50 value of 50.62 nM. This compound effectively induces cell cycle arrest at the G2/M phase and apoptosis, while also significantly augmenting the cytotoxic effects of temozolomide (TMZ) [1].
T13845	PROTAC PARP1 degrader	Others	Others
	PROTAC PARP1 degrader is a degrader of PARP1 based on the PROTAC technology. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line (IC50 of 6.12 μM).
T60567	PARP10/15-IN-2
	PARP10/15-IN-2 (Compound 8h) 是 PARP10和 PARP15的双重抑制剂，IC50值分别为 0.15 μM 和 0.37 μM。PARP10/15-IN-2 可以进入细胞并使细胞免于凋亡。
T79405	PARP1-IN-15	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP1-IN-15（Compound 6）是一款针对PARP1的抑制剂，能够抑制坦聚合酶(TNKS)并促进DNA双链断裂损伤。该化合物在诱导肿瘤细胞凋亡(apoptosis)方面具有显著作用，且在三阴性乳腺癌(TNBC)细胞及来源于TNBC患者的类器官中显示出抗癌活性，适用于探究BRCA1突变状态下的TNBC研究。
T12366	PARP14 inhibitor H10	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP14 inhibitor H10 is a selective inhibitor against PARP14 with IC50 of 490 nM
T72554	ARTD10/PARP10-IN-2
	ARTD10/PARP10-IN-2 是一种强效、非选择性的PARP 抑制剂。ARTD10/PARP10-IN-2 靶向单 ADP 核糖转移酶 (ARTD10/PARP10) 和聚 ADP-核糖聚合酶-1 (ARTD1/PARP1)，IC50分别为 2.0 μM，和 9.7 μM。
T81544	PARP1-IN-16	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP1-IN-16（化合物12a）是一款高效的PARP1抑制剂，其IC50为1.89 nM。该化合物能够促使细胞周期在S期停滞，并引发HCT-116细胞的凋亡。

化合物

Cat.No: T73007

Target: PARP

PARP1-IN-5 dihydrochloride

Cat.No: T9610

Target: PARP

ARTD10/PARP10-IN-1

Cat.No: T72553

Target: PARP

Cat.No: T67932

Target: PARP

Cat.No: T9891

Synonym: N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide

Target: PARP

PARP1/2/TNKS1/2-IN-1

Cat.No: T72437

Target: Apoptosis, PARP, Wnt/beta-catenin

Cat.No: T62955

Cat.No: T79593

Target: PARP

Cat.No: T73023

Cat.No: T61325

Cat.No: T81543

Target: PARP

PARP1/BRD4-IN-1

Cat.No: T63471

Cat.No: T60637

Cat.No: T60309

Cat.No: T60495

Cat.No: T61879

PARP1/BRD4-IN-2

Cat.No: T62540

Cat.No: T39139

Synonym: PARP1-IN-6

PARP11 inhibitor ITK7

Cat.No: T72397

Synonym: ITK7

Cat.No: T61694

PROTAC PARP1 degrader

Cat.No: T13845

Target: Others

Cat.No: T60567

Cat.No: T79405

Target: PARP

PARP14 inhibitor H10

Cat.No: T12366

Target: PARP

ARTD10/PARP10-IN-2

Cat.No: T72554

Cat.No: T81544

Target: PARP

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03065	BACE2 Protein, Mouse, Recombinant (His) CEAP1,BAE2,1110059C24Rik...	Mouse	HEK293 Cells
	BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 ...
TMPH-01941	PARP12 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	PARP12 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-01942	PARP14 Protein, Human, Recombinant (His & Myc)	Human	HEK293 Cells
	PARP14 Protein, Human, Recombinant (His & Myc) is expressed in HEK293.
TMPH-01879	PARP11 Protein, Human, Recombinant (His)	Human	E. coli
	Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis. PARP11 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 41.0 kDa and the accession number is Q9NR21.

重组蛋白

BACE2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03065

Species: Mouse

Expression System: HEK293 Cells

PARP12 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01941

Species: Human

Expression System: E. coli

PARP14 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01942

Species: Human

Expression System: HEK293 Cells

PARP11 Protein, Human, Recombinant (His)

Cat.No: TMPH-01879

Species: Human

Expression System: E. coli

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