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Search Results for " apn "

Targets Recommended: Others

18

抑制剂 & 化合物

3

天然产物

15

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T14311	APN-NH2	Others	Others
	APN- NH2 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
T17453	APN-PEG4-tetrazine	Others	Others
	APN-PEG4-tetrazine is a cleavable ADC linker compound comprised of four PEG units, specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1].
T17450	APN-PEG4-BCN	Others	Others
	APN-PEG4-BCN is a cleavable four-unit polyethylene glycol (PEG) linker, employed in the synthesis of antibody-drug conjugates (ADCs)[1].
T17451	APN-PEG4-DBCO	Others	Others
	APN-PEG4-DBCO is a cleavable linker for antibody-drug conjugates (ADCs), comprised of a four-unit PEG and a DBCO moiety. It finds application in the synthesis of ADCs[1].
T17452	APN-PEG4-PFP	Others	Others
	APN-PEG4-PFP is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14310	APN-C3-PEG4-azide	Others	Others
	APN-C3-PEG4-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14309	APN-C3-PEG4-alkyne	Others	Others
	APN-C3-PEG4-alkyne is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17449	APN-PEG4-Amine hydrochloride	Others	Others
	APN-PEG4-Amine (hydrochloride) is a cleavable four-unit polyethylene glycol (PEG) linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].
T14308	APN-C3-NH-Boc tert-Butyl 3-(4-(2-cyanoethynyl)phenylcarbamoyl)propylcarbamate	Others	Others
	APN-C3-NH-Boc is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T77836	APN-PEG36-tetrazine
	APN-PEG36-tetrazine是APN-PEG4-tetrazine的类似物，后者作为具有可降解(cleavable)特性的含四个单元PEG的ADC linker，应用于抗体偶联活性分子(ADC)的合成。
T61756	APN/AKT-IN-1
	APN/AKT-IN-1 is a potent dual inhibitor of aminopeptidase N (APN) and protein kinase B (AKT), exhibiting IC50 values of 0.21 μM and 0.27 μM for APN and AKT inhibition, respectively. This compound effectively suppresses the phosphorylation of glycogen synthase kinase 3 beta (GSK3β), which serves as an intracellular substrate of AKT [1].
T9321	zapnometinib ATR-002,3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid,PD0184264,2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid	Influenza Virus; MEK; Antibacterial	MAPK; Microbiology/Virology
	Zapnometinib (ATR-002) 是 CI-1040 的活性代谢物，是一种 MEK 抑制剂，IC50值为 5.7 nM，有抗流感病毒的抗病毒和抗菌活性。
T12159	APNEA (2R,3R,4S,5R)-2-[6-[2-(4-aminophenyl)ethylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol,N6-[2-(4-Aminophenyl)ethyl]adenosine,N6-[2-(4-氨基苯基)乙基]腺嘌呤	Adenosine Receptor	GPCR/G Protein; Neuroscience
	APNEA ((2R,3R,4S,5R)-2-[6-[2-(4-aminophenyl)ethylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol) 是腺苷 A3 受体的非选择性激动剂。
T23850	Capnoidine l-Capnoidine,l-Adlumidine,(-)-Adlumidine
	Capnoidine is a potential new anti-inflammatory drug lead candidate for diseases where current standard-of-care often fails and is associated with major side effects.
T124692	Capnolactone
	Capnolactone 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T124692，CAS号为 53771-63-4。
T27136	Debio-0827 PL37,PL-37,PL 37,Debio0827
	Debio-0827, a NEP and APN inhibitor, is used potentially for treatment of pain.
TP1771	NGR peptide Trifluoroacetate
	NGR peptide Trifluoroacetate containing the asparagine-glycine-arginine (NGR) motif is recognized by CD13/aminopeptidase N (APN) receptor isoforms that are selectively overexpressed in tumor neovasculature.
T38641	AP 811
	AP 811, a selective antagonist of the atrial natriuretic peptide clearance receptor (APN-CR, NPR3) with a K i value of 0.48 nM, exhibits remarkable selectivity for NPR3 over NPR1 by more than 20,000-fold. Moreover, AP 811 effectively eliminates ANP-induced pump stimulation.

化合物

Cat.No: T14311

Target: Others

APN-PEG4-tetrazine

Cat.No: T17453

Target: Others

Cat.No: T17450

Target: Others

APN-PEG4-DBCO

Cat.No: T17451

Target: Others

Cat.No: T17452

Target: Others

APN-C3-PEG4-azide

Cat.No: T14310

Target: Others

APN-C3-PEG4-alkyne

Cat.No: T14309

Target: Others

APN-PEG4-Amine hydrochloride

Cat.No: T17449

Target: Others

APN-C3-NH-Boc

Cat.No: T14308

Synonym: tert-Butyl 3-(4-(2-cyanoethynyl)phenylcarbamoyl)propylcarbamate

Target: Others

APN-PEG36-tetrazine

Cat.No: T77836

Cat.No: T61756

Cat.No: T9321

Synonym: ATR-002,3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid,PD0184264,2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid

Target: Influenza Virus, MEK, Antibacterial

Cat.No: T12159

Synonym: (2R,3R,4S,5R)-2-[6-[2-(4-aminophenyl)ethylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol,N6-[2-(4-Aminophenyl)ethyl]adenosine,N6-[2-(4-氨基苯基)乙基]腺嘌呤

Target: Adenosine Receptor

Cat.No: T23850

Synonym: l-Capnoidine,l-Adlumidine,(-)-Adlumidine

Cat.No: T124692

Cat.No: T27136

Synonym: PL37,PL-37,PL 37,Debio0827

NGR peptide Trifluoroacetate

Cat.No: TP1771

Cat.No: T38641

Cat. No.	Product Name	Target	Signaling Pathways
T3529	Bestatin hydrochloride 盐酸乌苯美司,Ubenimex hydrochloride,苯丁抑制素	Integrin; Aminopeptidase; Antibacterial; Antibiotic	Cytoskeletal Signaling; Metabolism; Microbiology/Virology
	Bestatin hydrochloride (Ubenimex hydrochloride) 是CD13(Aminopeptidase N)/APN 和leukotriene A4 hydrolase 抑制剂，可研究癌症。
T1257	Bestatin Ubenimex,乌苯美司	Others; Aminopeptidase; Antibacterial; Antibiotic; LTR	Immunology/Inflammation; Metabolism; Microbiology/Virology; Others
	Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂，可用于癌症研究。
T62258	Bestatin trifluoroacetate
	Bestatin trifluoroacetate (Ubenimex trifluoroacetate) 是一种 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂，经常用于研究癌症。

天然产物

Bestatin hydrochloride

Cat.No: T3529

Synonym: 盐酸乌苯美司,Ubenimex hydrochloride,苯丁抑制素

Target: Integrin, Aminopeptidase, Antibacterial, Antibiotic

Cat.No: T1257

Synonym: Ubenimex,乌苯美司

Target: Others, Aminopeptidase, Antibacterial, Antibiotic, LTR

Bestatin trifluoroacetate

Cat.No: T62258

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00665	Aminopeptidase N/CD13 Protein, Human, Recombinant (I603M, His) alanyl (membrane) aminopeptidase,LAP1,APN,CD13,P150...	Human	HEK293 Cells
	Aminopeptidase N/CD13 Protein, Human, Recombinant (I603M, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 104.2 kDa and the accession number is A0A024RC61.
TMPY-00758	Aminopeptidase N/CD13 Protein, Mouse, Recombinant (His) Cd13,AP-N,Apn,AP-M,P150,alanyl (membrane) aminopept...	Mouse	HEK293 Cells
	Aminopeptidase N/CD13 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 104 kDa and the accession number is P97449.
TMPY-01681	Adiponectin Protein, Mouse, Recombinant (His) apM1,Acdc,adiponectin, C1Q and collagen domain containing,Ac...	Mouse	HEK293 Cells
	Adiponectin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.4 kDa and the accession number is Q60994.
TMPH-01031	CAPN2 Protein, Human, Recombinant (His) Calpain-2 catalytic subunit,Millimolar-calpain,Calpain-2 lar...	Human	E. coli
	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. CAPN2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 82...
TMPH-01029	CAPN1 Protein, Human, Recombinant (His) CANPL1,CAPN1,Calpain-1 catalytic subunit,Micromolar...	Human	E. coli
	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409'. CAPN1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 85.9 kDa and the accession number is P07384.
TMPH-02557	CAPN1 Protein, Mouse, Recombinant (His) CANP 1,Calpain-1 catalytic subunit,muCANP,CANPL1,Calcium-act...	Mouse	E. coli
	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-388' and 'His-410'.
TMPH-01674	Human metapneumovirus (strain CAN97-83) Nucleoprotein/NP Protein (His & Myc)	HMPV	E. coli
	Encapsidates the viral RNA genome by forming a left-handed helical nucleocapsid that protects the RNA from nucleases. RNA replication depends on the availability of soluble nucleoprotein. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication.
TMPY-06206	Human metapneumovirus (strain HMPV/Homo sapiens/PER/CFI0466/2010/B) glycoprotein G Protein (His)	HMPV	HEK293 Cells
	Human metapneumovirus (strain HMPV/Homo sapiens/PER/CFI0466/2010/B) glycoprotein G Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.6 kDa and the accession number is X4Y8Q3.
TMPH-00060	ApNPV Viral cathepsin Protein (His & Myc) V-cath,Viral cathepsin,Cysteine proteinase (CP),VCATH	ApNPV	E. coli
	Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system. ApNPV Viral cathepsin Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 31.1 kDa and the accession number is Q91CL9.
TMPH-01672	Human metapneumovirus (strain CAN97-83) Matrix protein (His & Myc)	HMPV	E. coli
	Plays a crucial role in virus assembly into filaments and budding. Early in infection, localizes in the nucleus where it may inhibit host cell transcription. Later in infection, traffics to the cytoplasm through the action of host CRM1 to associate with inclusion bodies, the site of viral transcription and replication. During virus assembly and budding, acts as a bridge between the nucleocapsid and the lipid bilayer.
TMPH-01671	Human metapneumovirus (strain CAN97-83) Fusion glycoprotein F0 (His & SUMO)	HMPV	E. coli
	Inactive precursor that is cleaved to give rise to the mature F1 and F2 fusion glycoproteins.; Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the coiled coil regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The forma...
TMPH-01673	Human metapneumovirus (strain CAN97-83) Matrix protein (His)	HMPV	P. pastoris (Yeast)
	Plays a crucial role in virus assembly into filaments and budding. Early in infection, localizes in the nucleus where it may inhibit host cell transcription. Later in infection, traffics to the cytoplasm through the action of host CRM1 to associate with inclusion bodies, the site of viral transcription and replication. During virus assembly and budding, acts as a bridge between the nucleocapsid and the lipid bilayer.
TMPH-01030	CAPN14 Protein, Human, Recombinant (His & Myc) Calpain-14,Calcium-activated neutral proteinase 14,CAPN<...	Human	Baculovirus Insect Cells
	Calcium-regulated non-lysosomal thiol-protease. CAPN14 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 78.6 kDa and the accession number is A8MX76.
TMPY-06207	Human metapneumovirus (strain HMPV/Homo sapiens/PER/CFI0320/2010/A) glycoprotein G Protein (His)	HMPV	HEK293 Cells
	Human metapneumovirus (strain HMPV/Homo sapiens/PER/CFI0320/2010/A) glycoprotein G Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.4 kDa and the accession number is X4XYT2.
TMPY-06885	SARS-CoV-2 XBB.1.16 (Omicron) Spike S1+S2 trimer Protein (ECD, His)
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of...

重组蛋白

Aminopeptidase N/CD13 Protein, Human, Recombinant (I603M, His)

Cat.No: TMPY-00665

Species: Human

Expression System: HEK293 Cells

Aminopeptidase N/CD13 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00758

Species: Mouse

Expression System: HEK293 Cells

Adiponectin Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01681

Species: Mouse

Expression System: HEK293 Cells

CAPN2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01031

Species: Human

Expression System: E. coli

CAPN1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01029

Species: Human

Expression System: E. coli

CAPN1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02557

Species: Mouse

Expression System: E. coli

Human metapneumovirus (strain CAN97-83) Nucleoprotein/NP Protein (His & Myc)

Cat.No: TMPH-01674

Species: HMPV

Expression System: E. coli

Human metapneumovirus (strain HMPV/Homo sapiens/PER/CFI0466/2010/B) glycoprotein G Protein (His)

Cat.No: TMPY-06206

Species: HMPV

Expression System: HEK293 Cells

ApNPV Viral cathepsin Protein (His & Myc)

Cat.No: TMPH-00060

Species: ApNPV

Expression System: E. coli

Human metapneumovirus (strain CAN97-83) Matrix protein (His & Myc)

Cat.No: TMPH-01672

Species: HMPV

Expression System: E. coli

Human metapneumovirus (strain CAN97-83) Fusion glycoprotein F0 (His & SUMO)

Cat.No: TMPH-01671

Species: HMPV

Expression System: E. coli

Human metapneumovirus (strain CAN97-83) Matrix protein (His)

Cat.No: TMPH-01673

Species: HMPV

Expression System: P. pastoris (Yeast)

CAPN14 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01030

Species: Human

Expression System: Baculovirus Insect Cells

Human metapneumovirus (strain HMPV/Homo sapiens/PER/CFI0320/2010/A) glycoprotein G Protein (His)

Cat.No: TMPY-06207

Species: HMPV

Expression System: HEK293 Cells

SARS-CoV-2 XBB.1.16 (Omicron) Spike S1+S2 trimer Protein (ECD, His)

Cat.No: TMPY-06885

Expression System:

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