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抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T73998	ADAM8-IN-1
	ADAM8-IN-1 是一种有效的ADAM8抑制剂，其IC50值为 73 nM。
T27654	JG26 JG 26,JG-26	MMP; Immunology/Inflammation related	Immunology/Inflammation; Proteases/Proteasome
	JG26 是一种强效的 ADAM17 抑制剂，对 ADAM8、ADAM17、ADAM10 和 MMP-12 均有抑制作用，其 IC50 值分别为 12 nM、1.9 nM、150 nM 和 9.4 nM，可用于研究机体免疫系统。
T75998	cyclo(RLsKDK) TFA
	cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) 是一种特异性的金属蛋白酶 ADAM8抑制剂，IC50值为 182 nM。cyclo(RLsKDK) (TFA) 在炎性疾病和癌症中有潜在应用。
T72905	cyclo(RLsKDK) BK-1361
	Cyclo(RLsKDK) (BK-1361) 作为ADAM8金属蛋白酶的特异性抑制剂，展示出182 nM的IC50值。其在炎性疾病和癌症治疗中显示出潜在的应用价值。
T28985	TMI-1 WAY-171318	Apoptosis; MMP	Apoptosis; Proteases/Proteasome
	TMI-1 (WAY-171318) 是一种有效的抑制剂，用于抑制去整合素金属酶17 (ADAM17) 和其他基质金属蛋白酶MMPs。TMI-1 能够有效地抑制LPS 诱导的人原代单核细胞和人全血中TNF-α的分泌。TMI-1 在三阴性 (TN) 和过度表达ERBB2的乳腺肿瘤细胞系中选择性地诱导Caspase 依赖的细胞凋亡。

化合物

Synonym: JG 26,JG-26

Target: MMP, Immunology/Inflammation related

Synonym: WAY-171318

Target: Apoptosis, MMP

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00933	ADAM8/CD156a Protein, Mouse, Recombinant (His) CD156a,MGC134985,ADAM 8,Ms2,A...	Mouse	HEK293 Cells
	A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer. ADAM8/...
TMPK-00918	ADAM8/CD156a Protein, Human, Recombinant (aa 17-655, His) CD156a,ADAM 8,MGC134985,Adam<...	Human	HEK293 Cells
	A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer. ADAM8/...
TMPY-05532	ADAM8/CD156a Protein, Human, Recombinant (His) CD156,MS2,CD156a,ADAM metallopeptidase domain 8...	Human	HEK293 Cells
	ADAM8/CD156a Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71 kDa and the accession number is Q14C66.
TMPY-03877	ADAM8/CD156a Protein, Rhesus, Recombinant (His) ADAM metallopeptidase domain 8	Rhesus	HEK293 Cells
	ADAM8/CD156a Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.6 kDa and the accession number is XP_002805919.1.