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Cat. No.	Product Name	Target	Signaling Pathways
T40851	ACES N-氨基甲酰甲基乙磺酸,N-(2-Acetamido)-2-aminoethanesulfonic acid
	ACES, or N-(2-Acetamido)-2-aminoethanesulfonic acid, is a zwitterionic buffer compound. It offers an effective pH range of 6.8-7.2 for various applications.
T6249	Avagacestat BMS-708163	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Avagacestat (BMS-708163) 是一种有效的γ-secretase 抑制剂，抑制 Aβ42 (IC50:0.27 nM) 和 Aβ40 (IC50:0.30 nM) 的产生。它同时抑制 Notch 胞内结构域 (NICD) (IC50:0.84 nM) 和 CYP2C19 (IC50:20 nM) 。它可用于阿尔兹海默症的研究。
T13675	Elacestrant dihydrochloride RAD1901 dihydrochloride	Estrogen/progestogen Receptor	Endocrinology/Hormones
	Elacestrant dihydrochloride (DA-DKRAD1901 dihydrochloride) 是一种具有口服活性的的选择性雌激素受体 (ER) 降解剂 (SERD)，能够作用于 ERα (IC50:48 nM) 和 ERβ (IC50:870 nM)。
T13674	Elacestrant 依拉司群,RAD1901	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	Elacestrant (RAD1901) 是一种具有口服活性的、选择性的雌激素受体 (ER) 降解剂 (SERD)，能够作用于 ERα (IC50:48 nM)和 ERβ (IC50:870 nM)。
T3633	Crenigacestat LY3039478	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Crenigacestat (LY3039478) 是一种口服具有活性的Notch 和γ-secretase 的抑制剂，其在多种肿瘤细胞中的IC50为 ∼1nM。
T0940	Acesulfame Potassium	Others	Others
	Acesulfame potassium 是一种人造甜味剂，长期使用会影响认知功能，可能改变小鼠的神经代谢功能。
T6125	Semagacestat LY450139,塞美司他	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Semagacestat (LY450139) 是一种γ-secretase 抑制剂，抑制β-amyloid(Aβ42)，Aβ38和Aβ40，IC50分别为 10.9，12 和 12.1 nM，可用于研究阿尔茨海默病。
T6935	Nirogacestat PF-03084014,PF-3084014,PF03084014,PF 03084014	Apoptosis; Gamma-secretase	Apoptosis; Neuroscience; Proteases/Proteasome; Stem Cells
	Nirogacestat (PF 03084014) 是一种具有口服活性的，可逆的，非竞争性的，选择性γ-secretase 抑制剂，IC50为 6.2 nM。它抑制 Notch 信号通路，可研究 Notch 受体依赖性肿瘤。
T38266	Nirogacestat dihydrobromide
	Potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs. Lanz et al (2010) Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 334 269 PMID:20363853
T11173	Elacestrant S enantiomer RAD1901 S enantiomer	Others	Others
	Elacestrant S enantiomer is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively.
T30172	Aspartame acesulfame 乙酰舒泛-阿司帕坦盐,Aspartame acesulfame salt,Acesulfame mixture with aspartame
	Aspartame acesulfame, as an artificial sweetener, is 350 times sweeter than sucrose.
T14525	Begacestat GSI-953	Beta Amyloid	Neuroscience
	Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's disease.
T11173L	Elacestrant S enantiomer dihydrochloride RAD1901 S enantiomer dihydrochloride,RAD-1901 S enantiomer dihydrochloride,RAD 1901 S enantiomer dihydrochloride	Others	Others
	Elacestrant (RAD1901) dihydrochloride is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant S enantiomer dihydrochloride is an low activity enantiomer of elacestrant dihydrochloride.

化合物

Cat.No: T40851

Synonym: N-氨基甲酰甲基乙磺酸,N-(2-Acetamido)-2-aminoethanesulfonic acid

Cat.No: T6249

Synonym: BMS-708163

Target: Gamma-secretase

Elacestrant dihydrochloride

Cat.No: T13675

Synonym: RAD1901 dihydrochloride

Target: Estrogen/progestogen Receptor

Cat.No: T13674

Synonym: 依拉司群,RAD1901

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Cat.No: T3633

Synonym: LY3039478

Target: Gamma-secretase

Acesulfame Potassium

Cat.No: T0940

Target: Others

Cat.No: T6125

Synonym: LY450139,塞美司他

Target: Beta Amyloid, Gamma-secretase

Cat.No: T6935

Synonym: PF-03084014,PF-3084014,PF03084014,PF 03084014

Target: Apoptosis, Gamma-secretase

Nirogacestat dihydrobromide

Cat.No: T38266

Elacestrant S enantiomer

Cat.No: T11173

Synonym: RAD1901 S enantiomer

Target: Others

Aspartame acesulfame

Cat.No: T30172

Synonym: 乙酰舒泛-阿司帕坦盐,Aspartame acesulfame salt,Acesulfame mixture with aspartame

Cat.No: T14525

Synonym: GSI-953

Target: Beta Amyloid

Elacestrant S enantiomer dihydrochloride

Cat.No: T11173L

Synonym: RAD1901 S enantiomer dihydrochloride,RAD-1901 S enantiomer dihydrochloride,RAD 1901 S enantiomer dihydrochloride

Target: Others

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