首页工具

登录

搜索结果

Search Results for " abhd6 "

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T9687	MAGL-IN-4 His121 ARG57	Lipase	Metabolism
	MAGL-IN-4 (His121 ARG57) 是选择性的、口服有效的、可透过血脑屏障的、可逆的单酰基甘油脂肪酶抑制剂，IC50=6.2 nM。它主要通过大脑中选择性抑制 MAGL 增加 2-花生四烯酰甘油水平来增强内源性大麻素信号。
T9374	AA38-3 1-Piperidinecarboxylic acid, 4-nitrophenyl ester	FAAH; Lipase; MAGL	Metabolism; Neuroscience
	AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) 是丝氨酸水解酶抑制剂，能够抑制三种 SHs：ABHD6，ABHD11 和 FAAH。
T11785	KT203	MAGL	Metabolism
	KT203 是一种具有选择性和高效性的 α/β 水解酶结构域 6 (ABHD6) 抑制剂，具有潜在的抗病毒和抗炎活性，可用于研究肺炎。
T11784	KT182	MAGL	Metabolism
	KT182 是一个有效的、α/β 水解酶结构域 6 (ABHD6) 的选择性抑制剂，其在 Neuro2A 细胞中测得的 IC50 值为0.24 nM。
T15635	JZP-430	Lipase; MAGL	Metabolism
	JZP-430 是不可逆的、高度选择性的 α/β 水解酶结构域 6 抑制剂，能够靶向抑制人类 ABHD6 ，其 IC50=44 nM。
T22171	WWL123	MAGL	Metabolism
	WWL123 是一种有效的选择性 ABHD6 抑制剂，IC50 为 430 nM。WWL123 可穿过血脑屏障并抑制脑实质中的 ABHD6。WWL123 阻断 ABHD6 在 Pentylenetetrazole (PTZ)诱导的 R6/2 小鼠癫痫样发作和自发性癫痫发作中发挥抗癫痫作用。
T8997	WWL229	Others	Others
	WWL229 是羧酸酯酶3的选择性抑制剂 (IC50:1.94 µM) 。它可作用于培养脂肪细胞，提高脂质的储存，并减少基础脂肪分解。
T15668	KT185	Others	Others
	KT185 is an orally-bioavailable and brain-penetrant ABHD6 inhibitor (IC50: 0.21 nM in Neuro2A cells).
T17260	WWL70	Lipase; MAGL	Metabolism
	WWL70 是选择性 α/β 水解酶结构域 6 抑制剂，其IC50=70 nM。
T27652	JCP-170 JCP170
	JCP-170 is an ABHD6 inhibitor.
T29045	UCM710
	UCM710 is a dual inhibitor of α/β hydrolase domain 6 (ABHD6) and fatty acid amide hydrolase (FAAH).
T27653	JCP-265
	JCP-265 is an ABHD6 inhibitor.
T38031	(R)-KT109 (R)-KT109
	(R)-KT109 is the (R) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109 . (R)-KT109 is an inhibitor of DAGLβ (IC50 = 0.79 nM) and of DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol . It also inhibits α/β-hydrolase domain-containing protein 6 (ABHD6) with an IC50 value of 2.51 nM. (R)-KT109 is more potent at DAGLβ, DAGLα, and ABHD6 than (S)-KT109 .
T73317	JZP-MA-13
	JZP-MA-13是一种选择性α/β-水解酶结构域6 (ABHD6) 抑制剂，其IC50值为392 nM。该化合物对MAGL、ABHD12、FAAH或其它丝氨酸水解酶不表现出抑制作用。JZP-MA-13还被用作ABHD6在体内成像的正电子发射断层扫描(PET)配体。
T75022	JZP-MA-11
	JZP-MA-11是一种用于正电子发射断层扫描(PET)的配体，专一性靶向内源性大麻素α/β-水解酶结构域6(ABHD6)酶，并具有126 nM的IC50值，表明其对ABHD6有选择性抑制作用。JZP-MA-11能有效穿过血脑屏障(BBB)。[18F]JZP-MA-11展现出在靶向小鼠及非人灵长类(NHP)大脑ABHD6方面的临床前评估潜力。
T27811	LEI-106
	LEI-106, a novel potent sn-1 DAGLalpha inhibitor, blocks the hydrolysis of sn-1-oleoyl-2-AG, inhibits the hydrolysis of 2-AG by the monoacylglycerol lipase ABHD6.
T38316	ABC34
	ABC34 is an inactive control probe for JJH260 , the inhibitor of androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). ABC34 demonstrates an IC50 value greater than 25 μM for the inhibition of 9-PAHSA but is more potent in blocking the serine hydrolase ABHD6 and the palmitoyl-protein hydrolase PPT1, which are both off-targets of JJH260.
T40226	FP-Biotin
	FP-biotin is a potent organophosphorus toxicant, ideal for identifying novel biomarkers of organophosphorus toxicant exposure. It measures FAAH, ABHD6, and MAG-lipase activity, specifically in plasma studies, due to the efficient purification of biotinylated peptides through binding to immobilized avidin beads.
T38148	(S)-KT109 (S)-KT109
	(S)-KT109 is the (S) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109 . (S)-KT109 is a less potent inhibitor of DAGLβ (IC50 = 39.81 nM), DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (IC50 = 794.3 nM), and α/β-hydrolase domain-containing protein 6 (ABHD6; IC50 = 630.9 nM) than (R)-KT109 .
T38107	JJH260 JJH260
	JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA with an IC50 value of 0.57 μM. JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP; IC50 = 8.5 μM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA1 and LYPLA2. JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysa...
T27703	JZP-361 JZP361,JZP 361	Lipase	Metabolism
	JZP-361 是一种特异性 MAGL 抑制剂，对人重组 MAGL、人重组 FAAH 和人 hABHD6 的 IC50 分别为 46 nM、7.24 μM 和 1.79 μM。 JZP-361 具有抗组胺活性。 JZP-361可用于哮喘研究。
T12826	SA57	FAAH	Metabolism; Neuroscience
	SA57 is a potent, selective inhibitor of FAAH(IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH).

化合物

Cat.No: T9687

Synonym: His121 ARG57

Target: Lipase

Cat.No: T9374

Synonym: 1-Piperidinecarboxylic acid, 4-nitrophenyl ester

Target: FAAH, Lipase, MAGL

Cat.No: T11785

Target: MAGL

Cat.No: T11784

Target: MAGL

Cat.No: T15635

Target: Lipase, MAGL

Cat.No: T22171

Target: MAGL

Cat.No: T8997

Target: Others

Cat.No: T15668

Target: Others

Cat.No: T17260

Target: Lipase, MAGL

Cat.No: T27652

Synonym: JCP170

Cat.No: T29045

Cat.No: T27653

Cat.No: T38031

Synonym: (R)-KT109

Cat.No: T73317

Cat.No: T75022

Cat.No: T27811

Cat.No: T38316

Cat.No: T40226

Cat.No: T38148

Synonym: (S)-KT109

Cat.No: T38107

Synonym: JJH260

Cat.No: T27703

Synonym: JZP361,JZP 361

Target: Lipase

Cat.No: T12826

Target: FAAH

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼