18
8
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T41008 |
BODIPY-Cholesterol
BCh2 |
||
BODIPY-Cholesterol (TF-Chol)是一种带有荧光 BODIPY 基团和细胞通透性的胆固醇类似物,是一种新型 BODIPY 胆固醇探针。BODIPY-Cholesterol 可用于研究细胞内固醇摄取和细胞器间固醇通量。 | |||
T60796 |
Cholesterol 24-hydroxylase-IN-1
|
||
Cholesterol 24-hydroxylase-IN-1 (compound 17) 是具有口服活性且高选择性的胆固醇24-羟化酶(CH24H or CYP46A1)抑制剂,IC50值为8.5 nM,可以穿过血脑屏障。 | |||
T35977 |
6α-hydroxy Cholesterol
6α-hydroxy Cholesterol,6α-OHC |
||
6α-hydroxy Cholesterol is an oxysterol that increases superoxide anion production in SK-N-BE cells when used at concentrations of 50 and 100 μM.[1] | |||
T40140 |
Zanamivir-Cholesterol Conjugate
|
||
Zanamivir-cholesterol conjugate is an extended-duration neuraminidase inhibitor highly effective against drug-resistant influenza strains. | |||
T36217 |
19-hydroxy Cholesterol
|
||
19-hydroxy Cholesterol is formed during metabolic oxidation of cholesterol. It has been used as an internal standard for the quantitative determination of sterols by mass spectroscopic analysis.[1] | |||
T36130 |
22(S)-hydroxy Cholesterol
22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol |
||
22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22... | |||
T38045 |
Cholesterol β-D-Glucoside
|
||
Cholesterol β-D-glucoside is a derivative of cholesterol that contains β-D-glucose . It is formed from cholesterol and glucosylceramide by β-glucosidase 1. It activates heat shock transcription factor 1 (Hsf1) in response to heat shock, which increases the expression of heat shock protein 70 (Hsp70) in TIG-3 human fetal lung fibroblasts when used at a concentration of 10 μM. Cholesterol β-D-glucoside (100 mg/kg) prevents ulcer formation following cold-restraint stress and increases Hsf1 activity... | |||
T12225L |
Nevanimibe hydrochloride
PD-132301 hydrochloride,ATR101 hydrochloride |
Apoptosis; Acyltransferase | Apoptosis; Metabolism |
Nevanimibe hydrochloride (PD-132301 hydrochloride) 是一种口服有效的,选择性酰基辅酶 A:胆固醇 O-酰基转移酶 1 抑制剂,EC50为 9 nM。它抑制 ACAT2,EC50为 368 nM。它诱导细胞凋亡,具有抗肾上腺皮质癌的潜力。 | |||
T36998 |
7β,27-dihydroxy Cholesterol
7β,27-DHC,7β,27-dihydroxy Cholesterol |
||
7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 &#181M. It increases IL-17A production in Th17-polarized isolated hum... | |||
T77231 |
Cholesterol nervonate
|
||
Cholesterolnervonate 是一种生化试剂,可作为生物材料或有机化合物,用于生命科学相关研究。 | |||
T76139 | Cholesterol esterase | ||
胆固醇酯酶 (Cholesterol esterase) 是一种在肠道内将胆固醇酯水解为胆固醇和游离脂肪酸的酶。胆固醇在腺泡细胞中合成,储存在酶原颗粒中。胆固醇酯酶又称胆盐刺激脂肪酶、羧基酯脂肪酶,具有促进胆固醇吸收的作用。 | |||
T76128 | Cholesterol oxidase | ||
Cholesteroloxidase (ChOx),一种含有FAD的细菌黄素氧化酶,主要应用于生化研究领域。该酶专门催化胆固醇(及其他甾醇)的C(3)-OH基团,氧化生成cholest-5-en-3-one,并进一步异构化为cholest-4-en-3-one。 | |||
T65073 | Cholesterol n-Octanoate | ||
Cholesterol n-Octanoate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65073,CAS号为 1182-42-9。 | |||
T82731 |
Cholesterol 24-hydroxylase-IN-2
|
||
Cholesterol24-Hydroxylase-IN-2为胆固醇24-羟化酶(CH24H 或CYP46A1)抑制剂,具有5.4 nM的IC50值。该化合物适用于哺乳动物胆固醇24-羟化酶的成像研究。 | |||
T77270 | Cholesterol-PEG-Folate (MW 2000) | ||
Cholesterol-PEG-Folate (MW 2000) 是一种辅料,可用于制备叶酸偶联 PEG 脂质体。 | |||
T30961 |
CL 277082
CL277082,CL-277082,Ddpmhu |
Others | Others |
CL 277082 (Ddpmhu) 是一种酰基辅酶A:胆固醇O-酰基转移酶抑制剂,抑制肉芽肿组织 ACAT 活性。 | |||
T8314 |
RP-64477
RP64477 |
Acyltransferase | Metabolism |
RP-64477 是有效的胆固醇酯化酶酰基辅酶 A:胆固醇 O-酰基转移酶 (ACAT) 抑制剂。 | |||
T12225 |
Nevanimibe
ATR-101,PD-132301 |
Others | Others |
Nevanimibe is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM). |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12592 |
Pyripyropene A
|
Others | Others |
Pyripyropene A is a potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)(IC50 of 0.07 µM). | |||
T75552 | Pomonic acid | ||
Pomonic酸,作为一种三萜化合物,能显著抑制胆固醇酯的积累,并降低酰基辅酶A:胆固醇酰基转移酶(ACAT)的活性。 | |||
T36776 |
Terpendole C
|
||
Terpendole C is an indole diterpene alkaloid fungal metabolite originally isolated from A. yamanashiensis and an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 2.1 μM in rat liver microsomes). It also inhibits ACAT in J774 macrophages (IC50 = 0.46 μM) without affecting cell growth. | |||
T36931 |
Penicillide
|
||
Penicillide is a fungal metabolite originally isolated from Penicillium that has diverse biological activities. It is an inhibitor of calpain 2/m-calpain (IC50 = 7.1 μM) and acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 22.9 μM). It is also an antagonist of oxytocin receptors (IC50 = 67 μM). Penicillide inhibits RNA synthesis in P388 murine leukemia cells. | |||
T37690 |
Phenylpyropene A
|
||
Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM).1 Phenylpyropene A inhibits diacylglycerol acyltransferase (DGAT) in rat liver microsomes (IC50 = 78.7 μM). It induces mortality in 100% of M. persicae when used at a concentration of 5 ppm.3 |1. Kwon, O.E., Rho, M.C., Song, H.Y., et al. Phenylpyropene A and B, new inhibitors of ... | |||
T36226 |
Beauveriolide I
|
||
Beauveriolide I is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.78 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide I also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 6 μM).2 1.Namatame, I., Tomoda, H., Si, S., et al.Beauveriolides, specific i... | |||
T36329 |
Terpendole I
|
||
Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3 |1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Ter... | |||
T36227 | Beauveriolide III | ||
Beauveriolide III is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.41 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide III also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 5.5 μM).2Beauveriolide III (25 and 50 mg/kg) reduces the size of aortic ... |