Cat. No. | Product Name | Target | Signaling Pathways |
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T14021 |
20-HETE
20-hydroxy Arachidonic Acid |
Others | Others |
20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor and it is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE increases NADPH oxidase, ROS, and NF-κB activity, a | |||
T83968 |
20-HETE Intermediate 15
Methyl (5Z,8Z,11Z,14Z)-20-(acetyloxy)-5,8,11,14-eicosatetraenoate |
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20-HETE Intermediate 15 是20-羟基二十碳四烯酸的中间体。 | |||
T14186 |
17-ODYA
17-十八炔酸,Alkynyl Stearic Acid |
Others; PROTAC Linker | Others; PROTAC |
17-ODYA (Alkynyl Stearic Acid) 是 CYP450 ω-羟化酶抑制剂。它能够抑制与花生四烯酸孵育的大鼠肾皮质微粒体形成 20-HETE 、dihydroxyeicosatrienoic acids、epoxyeicosatrienoic acids。它可以改善异丙肾上腺素诱导的培养心肌细胞凋亡和坏死。 | |||
T83400 |
20-HETE inhibitor-1
|
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20-HETE inhibitor-1(comp 83)为一种20-HETE合成过程中的抑制剂。 | |||
T11556 |
HET0016
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Others | Others |
HET0016 is a potent and selective 20-HETE synthase inhibitor (IC50s: 17.7 nM, 12.1 nM, and 20.6 nM for recombinant CYP4A1-, CYP4A2- and CYP4A3-catalyzed 20-HETE synthesis). HET0016 also is a selective CYP450 inhibitor, which has been shown to inhibit angi | |||
T37826 |
CAY10462
CAY10462,CTK8E8405 |
P450 | Metabolism |
CAY10462 (CTK8E8405) 是一种有效的 20-HETE 合酶 CYP4A11 的选择性抑制剂,IC50 为 8.8 nM。 CAY10462 对 1A、1C 和 3A CYP450 酶的效力降低近 200 倍。 | |||
T13343 |
20-HEDE
WIT 002 |
Others | Others |
20-HEDE (WIT 002) is a 20-hydroxyeicosatetraenoic acid (20-HETE) antagonist. | |||
T67916 |
CYP4A11/CYP4F2-IN-2
|
P450 | Metabolism |
CYP4A11/CYP4F2-IN-2 是一种有效的和具有口服活性的细胞色素 P450 (CYP) 4A11 和 CYP4F2 的双重抑制剂,IC50 值分别为 140 nM 和 40 nM。CYP4A11/CYP4F2-IN-2可从肝脏和肾脏中提取, 具有治疗肾脏疾病的潜力。 | |||
T35467 |
(±)18-HETE
|
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(±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid. When formed by the CYP2E1 isoform, 18-HETE is comprised 100% of the (R) isomer. 18(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, whereas 18(S)-HETE does not affect perfusion pressure. 18-HETE has negligible effects on ATPase activity. 18(R)-HETE at 1 μM completely blocks 20-HETE-induced vasoconstriction of renal arterioles. | |||
T72501 |
CYP4A11/CYP4F2-IN-1
|
P450 | Metabolism |
CYP4A11/CYP4F2-IN-1 是一种高效的小分子细胞色素 P450 (CYP) 4A11 和 CYP4F2 抑制剂,对P450 (CYP) 4A11 的 IC50 值为 19 nM,对 CYP4F2 的 IC50 值为 17 nM。CYP4A11/CYP4F2-IN-1 可用于研究肾脏疾病和心脑血管疾病。 | |||
T36232 |
20-carboxy Arachidonic Acid
|
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20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-A... | |||
T36216 |
19(R)-HETE
|
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19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% of the (S) and (R) stereoisomers, respectively. Both 19(S)- and 19(R)-HETE are potent vasodilators of renal preglomerular vessels. However, 19(R)-HETE at 1 μM completely blocks 20-HETE-induced vasoconstriction of renal arterioles, whereas 19(S)-HETE remains inactive. | |||
T35855 |
AAA
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AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-induced phosphorylation of EGFR, NF-κB, and Akt in, and cell migration of, PC3 cells.In vivo, AAA (10 mg/kg per day) reduces systolic blood pressure, albuminuria, renal angiotensin II levels, and cardiac hypertrophy in a Cyp1a1-Ren-2 transgenic rat model of malignant hypertension... |