Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6647 |
Rotigotine-
Neupro,N-0923,罗替戈汀,N-0437,SPM 962 |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Rotigotine (N-0923) 是多巴胺受体激动剂,是5-HT1A receptor 的部分激动剂,以及α2B-肾上腺素受体的拮抗剂,用于治疗帕金森病和不宁腿综合征。 | |||
T6522 |
Guanabenz Acetate
Wy8678 acetate,BR-750,4-咪唑乙酸盐酸盐,Wytensin |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Guanabenz Acetate (Wytensin) 是一种 α2 肾上腺素激动剂,可用于高血压的研究。 | |||
T77566 |
(3aR,9aR)-Fluparoxan
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
(3aR,9aR)-Fluparoxan 是一种高度选择性和有效的肾上腺素能受体α2B 拮抗剂,可用于预防、改善或治疗神经发育障碍和神经退行性疾病。 | |||
T13804 |
OPC-28326
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
OPC-28326 是一种特异性的 α2-肾上腺素能受体拮抗剂,可作为外周血管扩张剂。 OPC-28326 抑制 α2A-、α2B- 和 α2C- 肾上腺素能受体,Ki 分别为 2040、285 和 55nM。 | |||
T12343 |
Benzquinamide
BZQ,P2647,Benzoquinamide |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Benzquinamide (P2647) 是一种具有抗癌活性的止吐剂, 抑制p糖蛋白介导的药物外排,增强多重耐药细胞中抗癌药物的细胞毒性。Benzquinamide 对 α2A, α2B, 以及α2C 肾上腺素能受体(α2-AR)的 Ki值分别为 1,365, 691 和 545 nM。 | |||
T26690 |
AVN-101
|
5-HT Receptor; Adrenergic Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
AVN-101 是一种非常有效的 5-HT7 受体拮抗剂 (Ki = 153 pM)。 AVN-101 还对组胺 H1 (Ki = 0.58 nM) 和肾上腺素能 α2A、α2B 和 α2C (Ki = 0.41-3.6 nM) 受体表现出相当高的亲和力。 AVN-101在中枢神经系统疾病动物模型中显示出良好的口服生物利用度和促进脑血屏障通透性、低毒性和合理的疗效。 | |||
T10264 |
AGN 192836
|
Others | Others |
AGN 192836 is a potent and selective α2 adrenergic agonist (EC50s: 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor). | |||
T36661 |
Iloperidone metabolite P95
Iloperidone metabolite P95 |
||
Iloperidone metabolite P95 is a metabolite of the atypical antipsychotic iloperidone . It binds to the serotonin (5-HT) receptor subtype 5-HT2A and α1-, α2B-, and α2C-adrenergic receptors with mean Ki values of 7.08, 21.38, 83.18, and 47.86 nM, respectively, but does not cross the blood-brain barrier. | |||
T35591 |
Guanfacine-13C,15N3
Guanfacine-13C,15N3 |
||
Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.1It has EC50values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki= 19 nM in a radioligand binding assay).2Guanfacin... |