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SLAMF7 Protein, Human, Recombinant (His)

SLAMF7 Protein, Human, Recombinant (His)

产品编号 TMPY-01483
别名: 19A, SLAM7, SLAM family member 7, CS1, CRACC, CD319

SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruit signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.

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SLAMF7 Protein, Human, Recombinant (His) Chemical Structure
SLAMF7 Protein, Human, Recombinant (His), CAS N/A
规格 价格/CNY 货期 数量
100 μg ¥ 2,320 现货
200 μg ¥ 4,110 5日内发货
产品目录号及名称: SLAMF7 Protein, Human, Recombinant (His) (TMPY-01483)
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参考文献
产品描述 SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruit signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
别名 19A, SLAM7, SLAM family member 7, CS1, CRACC, CD319
分子量 Approxiamtely 23.8 kDa

存储

Lyophilized powder: -20~-80°C for 1 year

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TargetMol Library Books参考文献

1. Lee JK,et al.(2004) Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. Eur J Immunol. 34(10): 2791-9. 2. Tassi I,et al.(2005) The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells. J Immunol. 175(12): 7996-8002. 3. Lee JK,et al.(2007) CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. J Immunol. 179(7): 4672-8. 4. Cruz-Munoz ME,et al.(2009) Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat Immunol. 10(3): 297-305.

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Keywords

SLAMF7 Protein, Human, Recombinant (His) 19A SLAM 7 CS-1 SLAM7 CD-319 SLAM family member 7 SLAM-7 CS1 CD 319 CS 1 CRACC CD319 Inhibitor inhibitor inhibit

 

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