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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12926	SJB3-019A	Others; DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others; Ubiquitination
	SJB3-019A 是一种有效的、有效的和新型的泛素特异性蛋白酶1（USP1）抑制剂，在 K562细胞中促进 ID1降解和细胞毒性的作用是 SJB2-043的5倍，IC50为0.0781 μM。SJB3-019A 抑制细胞增殖，使细胞凋亡。
T71651	GSK1370319A
	GSK1370319A is a potent P2X7 antagonist (IC50 = 3.2 nM). GSK1370319A inhibits ATP-induced increase in IL-1β release and caspase 1 activation in lipopolysaccharide (LPS)-primed mixed glia by blocking assembly of the inflammasome in a pannexin 1-dependent manner. GSK1370319A also inhibits ATP-induced subregion-specific neuronal loss in hippocampal organotypic slice cultures, which is dependent on its ability to prevent inflammasome assembly in glia. Significantly, GSK1370319A attenuates age-relate...
T79021	GSK3839919A
	GSK3839919A为高效HIV-1整合酶抑制剂。
T62796	VEGFR-2-IN-13
	VEGFR-2-IN-13 (Compound 19a) 是一种有效的 VEGFR-2 抑制剂 (IC50: 3.4 nM)。VEGFR-2-IN-13 能够将 HepG2 的细胞周期停滞在 G2/M 期，诱导细胞凋亡 (apoptosis)。
T60632	Xanthine oxidase-IN-4
	Xanthine oxidase-IN-4 (化合物 19a) 是一种具有口服活性的有效黄嘌呤氧化酶 (XO) 抑制剂，IC50值为0.039 μM，可用于高尿酸血症和痛风的研究。Xanthine oxidase-IN-4 在氧嗪酸钾诱导的高尿酸血症大鼠中表现出降尿酸能力。
T83529	(Rac)-Luciferin 6′-methyl ether sodium (Rac)-6′-Methoxyluciferin sodium
	D-Luciferin 6'-methyl ether (6'-Methoxyluciferin; compound 19a) sodium 是北美萤火虫Photinus pyralis荧光素酶 (PpyLuc) 的有效抑制剂，具有0.1 μM的IC50值。作为D-荧光素的类似物，本化合物在PpyLuc的ATP及荧光素结合位点展示了非特异性的相互作用。
T40100	D-Luciferin 6′-methyl ether 6′-Methoxyluciferin,D-Luciferin 6′-methyl ether
	D-Luciferin 6′-methyl ether (also known as 6′-Methoxyluciferin or compound 19a) is a highly effective inhibitor of luciferase obtained from the North American firefly Photinus pyralis (referred to as PpyLuc). It exhibits an IC50 value of 0.1 μM. This compound, which is an analog of D-luciferin, interacts non-specifically with the ATP and luciferin binding sites within the active site of PpyLuc.
T73129	STAT6-IN-1
	STAT6-IN-1（化合物19a）是一种针对STAT6的SH2结构域表现出较高亲和力（IC50=0.028 µM）的STAT6抑制剂。该化合物主要用于研究过敏性肺病、过敏性鼻炎、慢性阻塞性肺病或癌症。

化合物

SJB3-019A

Cat.No: T12926

Synonym:

Target: Others, DUB

Xanthine oxidase-IN-4

Cat.No: T60632

Synonym:

Target:

(Rac)-Luciferin 6′-methyl ether sodium

Cat.No: T83529

Synonym: (Rac)-6′-Methoxyluciferin sodium

Target:

D-Luciferin 6′-methyl ether

Cat.No: T40100

Synonym: 6′-Methoxyluciferin,D-Luciferin 6′-methyl ether

Cat. No.	Product Name	Target	Signaling Pathways
TN2664	19alpha-Hydroxyfern-7-ene	Others	Others
	19alpha-Hydroxyfern-7-ene 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2664，CAS号为 70588-12-4。
TN2839	2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid has anti-HIV activity. It shows an inhibitory effect on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and causes a significant delay o
TN1197	19α-Hydroxyasiatic acid 23-羟基委陵菜酸,19 alpha-Hydroxyasiatic acid	Others	Others
	19 alpha-Hydroxyasiatic acid shows significant anticoagulant effect on the extrinsic pathway.
T6116	Bleomycin Sulfate Blenoxane,硫酸博来霉素,硫酸博莱霉素,NSC125066	DNA/RNA Synthesis; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Bleomycin Sulfate (Blenoxane) 是一种糖肽抗生素，一种 DNA 合成抑制剂。Bleomycin Sulfate 可以引起 DNA 链断裂而不引起 RNA 链断裂。Bleomycin Sulfate 具有抗肿瘤活性。