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SLAMF7 Protein, Rhesus macaque, Recombinant (His)

SLAMF7 Protein, Rhesus macaque, Recombinant (His)

产品编号 TMPJ-01442   CAS TMPJ-01442
别名: CD2 Subset 1, CD2-Like Receptor-Activating Cytotoxic Cells, Novel Ly9, Membrane Protein FOAP-12, CRACC, Protein 19A, CD319, CS1, SLAMF7, SLAM Family Member 7

SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.

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SLAMF7 Protein, Rhesus macaque, Recombinant (His) Chemical Structure
SLAMF7 Protein, Rhesus macaque, Recombinant (His), CAS TMPJ-01442
规格 价格/CNY 货期 数量
10 μg ¥ 550 5日内发货
50 μg ¥ 1,670 5日内发货
500 μg ¥ 13,700 5日内发货
1 mg ¥ 20,500 5日内发货

SLAMF7 Protein, Rhesus macaque, Recombinant (His) 的其他形式现货产品:

Coppersensor 1 SLAMF7 Protein, Human, Recombinant (His)
产品目录号及名称: SLAMF7 Protein, Rhesus macaque, Recombinant (His) (TMPJ-01442)
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产品描述 SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
别名 CD2 Subset 1, CD2-Like Receptor-Activating Cytotoxic Cells, Novel Ly9, Membrane Protein FOAP-12, CRACC, Protein 19A, CD319, CS1, SLAMF7, SLAM Family Member 7
分子量 30-50 KDa, reducing conditions
CAS No. TMPJ-01442

存储

Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month

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Keywords

SLAMF7 Protein, Rhesus macaque, Recombinant (His) TMPJ-01442 SLAMF-7 CD-319 CS 1 CD2 Subset 1 CD2-Like Receptor-Activating Cytotoxic Cells Novel Ly9 Membrane Protein FOAP-12 CS-1 CRACC Protein 19A CD319 SLAMF 7 CS1 SLAMF7 SLAM Family Member 7 CD 319 Inhibitor inhibitor inhibit

 

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