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S100A10 Protein, Human, Recombinant (His)

产品编号 TMPY-01926

别名: ANX2L, S100 calcium binding protein A10, p10, CLP11, MGC111133, GP11, 42C, ANX2LG, Ca[1], CAL1L, P11

S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S1 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. Protein S100-A10, also known as Calpactin I light chain, Cellular ligand of annexin II, S100 calcium-binding protein A10, p10 protein, p11, ANX2LG and S100A10, is a member of the S100 family of small, dimeric EF hand-type Ca(2+)-binding proteins that generally modulate cellular target proteins in response to intracellular Ca(2+) signals. In contrast to all other S100 proteins, S100A10 is Ca(2+) insensitive because of amino acid replacements in its Ca(2+)-binding loops that lock the protein in a permanently active state. S100A10 forms a heterotetramer with annexin IIH and promotes carcinoma invasion and metastasis by plasminogen activation. S100A10 and annexin II contribute to the aggressive characteristics of anaplastic carcinoma, while playing a constitutive role in papillary carcinoma. S100A10 induces the dimerization of ANXA2 / p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target of tyrosine-specific kinase. S100A10 functions as a linker tethering certain transmembrane proteins to annexin A2 thereby assisting their traffic to the plasma membrane and/or their firm anchorage at certain membrane sites. 在相同实验条件下，摩尔浓度相同的化合物盐形式与游离态具有相同的生物活性，但盐形式 P11 acetate 的水溶性和稳定性通常比游离态更好。

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S100A10 Protein, Human, Recombinant (His) Chemical Structure

S100A10 Protein, Human, Recombinant (His), CAS N/A

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		5日内发货

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S100A10 Protein, Human, Recombinant (His) 的其他形式现货产品:

P11 acetate

其他形式的 S100A10 Protein, Human, Recombinant (His):

P11 acetate
现货
HSDVHK-NH2
询价

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述

别名	ANX2L, S100 calcium binding protein A10, p10, CLP11, MGC111133, GP11, 42C, ANX2LG, Ca[1], CAL1L, P11
分子量	12.6 kDa (predicted)

存储

Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

溶液体积

质量

配液浓度

参考文献

1. Gebhardt, C. et al., 2006, Biochem Pharmacol. 72 (11):1622-31. 2. Ito,Y. et al., 2007, Anticancer Res. 27 (4C):2679-83. 3. Svenningsson,P. et al., 2007, Curr Opin Pharmacol 7 (1):27-32. 4. Rescher,U. et al., 2008, Pflugers Arch. 455 (4):575-82. 5. Nonaka, D. et al., 2008, J. Cutan. Pathol. 35 (11): 1014-9. 6. Lim, SY. et al., 2008, J Immunol. 181 (8): 5627-36. 7. Heibeck TH. et al., 2009, J. Proteome Res. 8:3852-61.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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