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CD45 Protein, Mouse, Recombinant (His)

CD45 Protein, Mouse, Recombinant (His)

产品编号 TMPJ-00794   CAS TMPJ-00794
别名: CD45, receptor-type tyrosine-protein phosphatase C, CD45R, L-CA, LY5, CD45 antigen, LCA, B220, PTPRC, protein tyrosine phosphatase, receptor type, C

Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. It is a variably glycosylated 180-220 kDa transmembrane protein that is abundantly expressed on all nucleated cells of hematopoietic origin. CD45 has several isoforms, expressed according to cell type, developmental stage and antigenic exposure. CD45 has been best studied in T cells, where it determines T cell receptor signaling thresholds. CD45 is moved into or out of the immunological synapse (IS) membrane microdomain depending on the relative influence of interaction with the extracellular galectin lattice or the intracellular actin cytoskeleton. Galectin interaction can be fine-tuned by varying usage of the heavily O-glycosylated spliced regions and sialylation of N-linked carbohydrates. Within the IS, CD45 dephosphorylates and negatively regulates the src family kinase, LCK. In other leukocytes, CD45 influences differentiation and links immunoreceptor signaling with cytokine secretion and cell survival, partially overlapping in function with DEP-1/CD148. CD45 deletion causes in severe immunodeficiency, while point mutations may be associated with autoimmune disorders.

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CD45 Protein, Mouse, Recombinant (His) Chemical Structure
CD45 Protein, Mouse, Recombinant (His), CAS TMPJ-00794
规格 价格/CNY 货期 数量
10 μg ¥ 1,170 5日内发货
50 μg ¥ 3,450 5日内发货
500 μg ¥ 17,800 5日内发货
1 mg ¥ 26,700 5日内发货

CD45 Protein, Mouse, Recombinant (His) 的其他形式现货产品:

CD45 Protein, Human, Recombinant (aa 1-529, His) B220 CD45 Protein, Human, Recombinant (aa 26-577, His)
产品目录号及名称: CD45 Protein, Mouse, Recombinant (His) (TMPJ-00794)
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产品描述 Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. It is a variably glycosylated 180-220 kDa transmembrane protein that is abundantly expressed on all nucleated cells of hematopoietic origin. CD45 has several isoforms, expressed according to cell type, developmental stage and antigenic exposure. CD45 has been best studied in T cells, where it determines T cell receptor signaling thresholds. CD45 is moved into or out of the immunological synapse (IS) membrane microdomain depending on the relative influence of interaction with the extracellular galectin lattice or the intracellular actin cytoskeleton. Galectin interaction can be fine-tuned by varying usage of the heavily O-glycosylated spliced regions and sialylation of N-linked carbohydrates. Within the IS, CD45 dephosphorylates and negatively regulates the src family kinase, LCK. In other leukocytes, CD45 influences differentiation and links immunoreceptor signaling with cytokine secretion and cell survival, partially overlapping in function with DEP-1/CD148. CD45 deletion causes in severe immunodeficiency, while point mutations may be associated with autoimmune disorders.
别名 CD45, receptor-type tyrosine-protein phosphatase C, CD45R, L-CA, LY5, CD45 antigen, LCA, B220, PTPRC, protein tyrosine phosphatase, receptor type, C
分子量 120-160 KDa, reducing conditions
CAS No. TMPJ-00794

存储

Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month

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Keywords

CD45 Protein, Mouse, Recombinant (His) TMPJ-00794 B-220 CD45 CD-45 receptor-type tyrosine-protein phosphatase C B 220 CD45R LY 5 CD 45 L-CA LY5 CD45 antigen LCA B220 LY-5 PTPRC protein tyrosine phosphatase, receptor type, C Inhibitor inhibitor inhibit

 

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