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IFNAR1 Protein, Human, Recombinant (His)

IFNAR1 Protein, Human, Recombinant (His)

产品编号 TMPY-02647
别名: interferon (alpha, beta and omega) receptor 1, IFN-α-REC, IFRC, IFNBR, IFNAR, IFN-alpha-REC, AVP, interferon (α, β and ω) receptor 1, interferon (α, β and Ω) receptor 1

Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant-negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.

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IFNAR1 Protein, Human, Recombinant (His) Chemical Structure
IFNAR1 Protein, Human, Recombinant (His), CAS N/A
规格 价格/CNY 货期 数量
100 μg ¥ 4,310 现货
200 μg ¥ 7,630 5日内发货
500 μg ¥ 16,130 5日内发货
产品目录号及名称: IFNAR1 Protein, Human, Recombinant (His) (TMPY-02647)
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纯度: SDS-PAGE: 99.1%; SEC-HPLC: 97.5%
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参考文献
产品描述 Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant-negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
别名 interferon (alpha, beta and omega) receptor 1, IFN-α-REC, IFRC, IFNBR, IFNAR, IFN-alpha-REC, AVP, interferon (α, β and ω) receptor 1, interferon (α, β and Ω) receptor 1
分子量 48.6 kDa (predicted)

存储

Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month

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TargetMol Library Books参考文献

1. Yan H,et al.(1996) Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 15(5): 1064-74. 2. Richter MF,et al.(1998) Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem. 273(38): 24723-9. 3. Abramovich C,et al.(1997) A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16(2): 260-6.

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Keywords

IFNAR1 Protein, Human, Recombinant (His) interferon (alpha, beta and omega) receptor 1 IFN-α-REC IFRC IFNBR IFNAR IFN-a-REC IFN-alpha-REC AVP interferon (α, β and ω) receptor 1 interferon (a, b and w) receptor 1 interferon (α, β and Ω) receptor 1 Inhibitor inhibitor inhibit

 

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