Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tecalcet Hydrochloride (R-568 hydrochloride) 是钙敏感受体 (CaSR) 的变构正向调节剂。 Tecalcet Hydrochloride 增加了对细胞外钙离子活化的敏感性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 276 | 现货 | ||
2 mg | ¥ 476 | 现货 | ||
5 mg | ¥ 996 | 现货 | ||
10 mg | ¥ 1,670 | 现货 | ||
25 mg | ¥ 3,930 | 现货 | ||
50 mg | ¥ 5,630 | 现货 | ||
100 mg | ¥ 7,860 | 现货 | ||
200 mg | ¥ 10,600 | 现货 | ||
500 mg | ¥ 15,700 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,170 | 现货 |
产品描述 | Tecalcet Hydrochloride (R-568 hydrochloride) is an allosteric and positive modulator of the calcium-sensing receptor(CaSR). Tecalcet Hydrochloride increases the sensitivity to the activation of extracellular Ca2+. |
体外活性 | Tecalcet Hydrochloride (0.1-100 nM) shifts the concentration-response curve for extracellular Ca2 to the left and decreases the EC50 value to 0.61 mM. Tecalcet Hydrochloride (0.1-100 μM) increases Ca2+ in a dose-dependent and stereoselective manner[3]. |
体内活性 | In male Sprague-Dawley rats with renal insufficiency, Tecalcet Hydrochloride (1.5 and 15 mg/kg, oral) inhibits PT cell proliferation and reduces serum PTH level in a dose-dependent manner. Tecalcet Hydrochloride reduces the number of BrdU-positive PT cells by 20% at a low dose (1.5 mg/kg), and by 50% at a high dose (15 mg/kg)[1]. |
别名 | R-568 盐酸盐, R-568 hydrochloride, R-568 (hydrochloride) |
分子量 | 340.29 |
分子式 | C18H23Cl2NO |
CAS No. | 177172-49-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (117.5 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.9387 mL | 14.6933 mL | 29.3867 mL | 73.4667 mL |
5 mM | 0.5877 mL | 2.9387 mL | 5.8773 mL | 14.6933 mL | |
10 mM | 0.2939 mL | 1.4693 mL | 2.9387 mL | 7.3467 mL | |
20 mM | 0.1469 mL | 0.7347 mL | 1.4693 mL | 3.6733 mL | |
50 mM | 0.0588 mL | 0.2939 mL | 0.5877 mL | 1.4693 mL | |
100 mM | 0.0294 mL | 0.1469 mL | 0.2939 mL | 0.7347 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tecalcet Hydrochloride 177172-49-5 GPCR/G Protein CaSR R568 R-568 盐酸盐 R-568 R-568 hydrochloride R568 Hydrochloride R-568 (hydrochloride) R 568 R-568 Hydrochloride R 568 Hydrochloride Inhibitor inhibitor inhibit