Powder: -20°C for 3 years | In solvent: -80°C for 1 year
T-2000 (DMMDPB) 是一种 GABA 受体激动剂,可用于研究肌阵挛和本质性震颤。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 990 | 现货 | ||
5 mg | ¥ 2,460 | 现货 | ||
10 mg | ¥ 3,680 | 现货 | ||
25 mg | ¥ 5,930 | 现货 | ||
50 mg | ¥ 8,220 | 现货 | ||
100 mg | ¥ 10,800 | 现货 | ||
500 mg | ¥ 22,200 | 现货 |
产品描述 | T-2000 (DMMDPB) is a GABA receptor agonist that can be used to study myoclonus and essential tremor. |
体内活性 | T2000 (1,3-dimethoxymethyl-5,5-diphenyl-barbituric acid; DMMDPB) on essential tremor, given in twice daily doses of 400 and 300 mg, In the first study of 12 patients treated with 400 mg or placebo twice daily for 14 days, the mean change from baseline at day 14 was 19.3 (P < 0.0001) in the treated group and 9.0 (P = 0.0121) in the control group. Using a two-factor mixed ANOVA model to evaluate within-group and between-group changes, the effect of T2000 was significantly different from that of the placebo group (P = 0.03). In the second study of 22 patients treated with 300 mg of T2000 or placebo twice daily for 20 days, statistically significant changes were seen in treated patients compared to baseline, but the ANOVA model did not demonstrate a significant treatment effect of T2000 compared to placebo. When the treated groups from each study are compared, the 800-mg daily group is significantly different from the 600-mg daily group (P = 0.02).[2] |
别名 | DMMDPB |
分子量 | 368.38 |
分子式 | C20H20N2O5 |
CAS No. | 97846-21-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (149.3 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7146 mL | 13.5729 mL | 27.1459 mL | 67.8647 mL |
5 mM | 0.5429 mL | 2.7146 mL | 5.4292 mL | 13.5729 mL | |
10 mM | 0.2715 mL | 1.3573 mL | 2.7146 mL | 6.7865 mL | |
20 mM | 0.1357 mL | 0.6786 mL | 1.3573 mL | 3.3932 mL | |
50 mM | 0.0543 mL | 0.2715 mL | 0.5429 mL | 1.3573 mL | |
100 mM | 0.0271 mL | 0.1357 mL | 0.2715 mL | 0.6786 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
T-2000 97846-21-4 Membrane transporter/Ion channel Neuroscience GABA Receptor T2000 DMMDPB T 2000 Inhibitor inhibitor inhibit