Powder: -20°C for 3 years | In solvent: -80°C for 1 year
STK16-IN-1是一种STK16激酶抑制剂(IC50:295 nM)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 233 | 现货 | ||
2 mg | ¥ 329 | 现货 | ||
5 mg | ¥ 538 | 现货 | ||
10 mg | ¥ 953 | 现货 | ||
25 mg | ¥ 1,990 | 现货 | ||
50 mg | ¥ 2,980 | 现货 | ||
100 mg | ¥ 4,290 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 589 | 现货 |
产品描述 | STK16-IN-1 is an inhibitor of STK16 kinase (IC50: 295 nM). |
靶点活性 | STK16:295 nM |
体外活性 | STK16-IN-1 inhibits mTOR kinase (IC50: 5.56 μM). STK16-IN-1 shows potent inhibitory activity against STK16 kinase (IC50=0.295 μM) with excellent selective across the kinome as assessed using the KinomeScanTM profiling assay. STK16-IN-1 treatment causes a reduction in cell number and accumulation of binucleated cells, which can be recapitulated by RNAi knockdown of STK16 in MCF-7 cells. Co-treatment of STK16-IN-1 with chemotherapeutics such as cisplatin, doxorubicin, colchicine and paclitaxel results in a slight potentiation of the anti-proliferative effects of the chemotherapeutics. STK16-IN-1 provides a useful tool compound for further elucidating the biological functions of STK16) [1]. |
分子量 | 293.3 |
分子式 | C17H12FN3O |
CAS No. | 1223001-53-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 15 mg/mL (51.14 mM), Sonication and heating are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.4095 mL | 17.0474 mL | 34.0948 mL | 85.237 mL |
5 mM | 0.6819 mL | 3.4095 mL | 6.819 mL | 17.0474 mL | |
10 mM | 0.3409 mL | 1.7047 mL | 3.4095 mL | 8.5237 mL | |
20 mM | 0.1705 mL | 0.8524 mL | 1.7047 mL | 4.2618 mL | |
50 mM | 0.0682 mL | 0.3409 mL | 0.6819 mL | 1.7047 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
STK16-IN-1 1223001-53-3 Others STK16IN1 STK-16-IN-1 Inhibitor STK16 IN 1 inhibit inhibitor