Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NBQX Disodium (FG9202 disodium) 是高度选择性,竞争型的 AMPA 受体拮抗剂, 具有保护神经系统和抗惊厥活性的作用。NBQX Disodium 是NBQX 的盐类物质。 NBQX 是一种有效并具有选择性的AMPA /红藻氨酸受体拮抗剂,可用于拮抗谷氨酸的兴奋性毒性。在啮齿类动物模型中具有抗惊厥作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 592 | 现货 | ||
5 mg | ¥ 1,360 | 现货 | ||
10 mg | ¥ 1,720 | 现货 | ||
25 mg | ¥ 3,490 | 现货 | ||
50 mg | ¥ 4,960 | 现货 | ||
100 mg | ¥ 7,190 | 现货 |
产品描述 | NBQX Disodium (FG9202 disodium) is a highly selective, competitive AMPA receptor antagonist with neuroprotective and anticonvulsant activity. NBQX Disodium is a salt of NBQX. NBQX is a potent and selective AMPA/rhodosinate receptor antagonist that can be used to antagonize the excitatory toxicity of glutamate. It has anticonvulsant effects in rodent models. |
靶点活性 | AMPA:0.7 ± 0.1 μM, Kainic acid:0.7 ± 0.03 μM |
体外活性 | In HIP-009 cells, NBQX disodium salt inhibited both AMPA or kainic acid (KA) induced signals in a concentration-dependent manner, with IC50 values being 0.7 ± 0.1 and 0.7 ± 0.03 μM, respectively. The AMPA-evoked calcium rise was completely inhibited by NBQX disodium salt, whereas 68.6% ± 1.3% inhibition of the KA-induced signal was observed with 30 μM of NBQX disodium salt treatment.[1] |
体内活性 |
Administration of NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) exhibits a reduction in PTZ-induced seizures. [2] In a rat model of focal ischemia, NBQX disodium demonstrates neuroprotective effects when administered intravenously as a bolus dose of 30 mg/kg at the time of MCA occlusion, followed by an additional dose at 1 hour post-occlusion. [3] |
别名 | FG9202 disodium, NBQX 2Na |
分子量 | 380.24 |
分子式 | C12H6N4Na2O6S |
CAS No. | 479347-86-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 34.2 mg/mL(90.0 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 2.6299 mL | 13.1496 mL | 26.2992 mL | 65.7479 mL |
5 mM | 0.526 mL | 2.6299 mL | 5.2598 mL | 13.1496 mL | |
10 mM | 0.263 mL | 1.315 mL | 2.6299 mL | 6.5748 mL | |
20 mM | 0.1315 mL | 0.6575 mL | 1.315 mL | 3.2874 mL | |
50 mM | 0.0526 mL | 0.263 mL | 0.526 mL | 1.315 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
NBQX Disodium 479347-86-9 Neuroscience GluR FG 9202 FG9202 disodium FG-9202 NBQX NBQX 2Na FG9202 Inhibitor inhibitor inhibit