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LTX315 acetate

产品编号 T6881L

别名: LTX315醋酸盐, KKWWKKW-Dip-K-NH2 acetate, Oncopore acetate, Ruxotemitide acetate, LTX315 acetate(1345407-05-7, Free base)

LTX315 acetate (Oncopore acetate) 是一种具有强抗癌活性的溶瘤肽，MRC-5 的 IC50 值分别为 34.3 µM、A20 和 AT84 分别为 8.3 µM 和 11 µM。

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LTX315 acetate, CAS N/A

规格	价格/CNY	货期
1 mg	￥ 655	现货
2 mg	￥ 957	现货
5 mg	￥ 1,310	现货
10 mg	￥ 2,290	现货
25 mg	￥ 3,890	现货
50 mg	￥ 5,560	现货
100 mg	￥ 7,790	现货

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纯度: 99.93%

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	LTX315 acetate (Oncopore acetate) is an oncolytic peptide with potent anticancer activity, with IC50 values of 34.3 µM for MRC-5, 8.3 µM for A20, and 11 µM for AT84, respectively.
靶点活性	A20:8.3 µM, AT84:11 µM, MRC5:34.3 µM
体外活性	LTX315 acetate induces rapid killing of cancer cells. LTX315 acetate is equally potent against drug-resistant cancer cells, non-toxic to erythrocytes, shows high plasma protein binding, and can be rapidly degraded to non-toxic metabolites. The oncolytic activity of LTX315 acetate results from direct lysis of the plasma membrane and permeabilization of the mitochondrial membrane, resulting in cell death due to necrosis and release of tumor antigens. Treatment of cancer cells with LTX315 acetate results in the release of several danger signals (DAMPs) that are associated with immunogenic cell death and stimulation of adaptive immune responses[1].
体内活性	Intratumoral administration of LTX315 acetate resulted in tumor necrosis and immune cell infiltration into the tumor parenchyma, followed by complete tumor regression in most animals. LTX-315 induces the release of risk-associated molecular patterning molecules, such as high mobility group box-1 proteins, in vitro, followed by upregulation of pro-inflammatory cytokines such as interleukin (IL) 1β, IL6, and IL18 in vivo. Animals cured by LTX315 acetate treatment were protected from rechallenging with live intradermal and intravenous B16 tumor cells [2].

别名	LTX315醋酸盐, KKWWKKW-Dip-K-NH2 acetate, Oncopore acetate, Ruxotemitide acetate, LTX315 acetate(1345407-05-7, Free base)
分子量	1499.84
分子式	C80H110N18O11

存储

store at low temperature,keep away from moisture　|　Powder: -20°C for 3 years | In solvent: -80°C for 1 year

计算器

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参考文献

1. Haug BE, et al. Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. 2. Camilio KA, et al. Complete regression and systemic protective immune responses obtained in B16 melanomas after treatment with LTX-315. Cancer Immunol Immunother. 2014 Jun;63(6):601-13.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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