Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GKI-1是 Greatwall (GWL)激酶抑制剂,对 hGWLFL 具有抑制,其 IC50为4.9。GKI-1对 hGWL-KinDom 也具有抑制作用,其 IC50 为 2.5 µM。GKI-1 对 ROCK1抑制效果比 hGWLFL 和hGWL-KinDom 好,其IC50为11 µM, 仅微弱抑制 PKA。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,490 | 现货 | ||
5 mg | ¥ 3,730 | 现货 | ||
10 mg | ¥ 5,390 | 现货 | ||
25 mg | ¥ 8,350 | 现货 | ||
50 mg | ¥ 11,200 | 现货 | ||
100 mg | ¥ 15,180 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 4,120 | 现货 |
产品描述 | GKI-1 is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL with an IC50 of 4.9. GKI-1 also inhibited hGWL-KinDom, and its IC50 was 2.5 µM. The inhibitory effect of GKI-1 on ROCK1 was better than that of hGWLFL and hGWL-KinDom, and its IC50 was 11 µM, which only weakly inhibited PKA. |
靶点活性 | GWL-KinDom (human):4.9 µM , GWLFL (human):4.9 µM , GWLFL (human):4.9 µM, GWL-KinDom (human):2.5 µM, ROCK1:11 µM |
体外活性 | Treatment of HeLa cells with GKI-1 (25 and 50µM, 0-8.5 h) reduced ENSA/ARPP19 phosphorylation levels, resulting in reduced mitotic events, mitotic arrest/cell death, and cell division failure. GKI-1 inhibited full-length human GWL and showed cellular effects[1] |
分子量 | 269.73 |
分子式 | C15H12ClN3 |
CAS No. | 2444764-03-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 180.0 mg/mL (667.3 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.7074 mL | 18.5371 mL | 37.0741 mL | 92.6853 mL |
5 mM | 0.7415 mL | 3.7074 mL | 7.4148 mL | 18.5371 mL | |
10 mM | 0.3707 mL | 1.8537 mL | 3.7074 mL | 9.2685 mL | |
20 mM | 0.1854 mL | 0.9269 mL | 1.8537 mL | 4.6343 mL | |
50 mM | 0.0741 mL | 0.3707 mL | 0.7415 mL | 1.8537 mL | |
100 mM | 0.0371 mL | 0.1854 mL | 0.3707 mL | 0.9269 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
GKI-1 2444764-03-6 Others GKI 1 GKI1 Inhibitor inhibitor inhibit