Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Antifolate C2 (AGF 154) 具有抗肿瘤活性,在人肿瘤细胞的生长抑制实验中测得IC为0.14nM。Antifolate C2 可用于研究癌症和自身免疫疾病。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 2,350 | 现货 | ||
5 mg | ¥ 5,630 | 现货 | ||
10 mg | ¥ 7,790 | 现货 | ||
25 mg | ¥ 11,200 | 现货 | ||
50 mg | ¥ 13,800 | 现货 | ||
100 mg | ¥ 17,500 | 现货 | ||
500 mg | ¥ 38,500 | 现货 |
产品描述 | Antifolate C2 (AGF 154) has antitumor activity with an IC of 0.14 nM measured in a growth inhibition assay of human tumor cells.Antifolate C2 can be used for the study of cancer and autoimmune diseases. |
体内活性 | Antifolate C2 (AGF154) was synthesized as a potential antitumor agent. AGF154 inhibited the proliferation of Chinese hamster ovary (CHO) sublines expressing folate receptors (FRs) α or β (IC50s < 1 nM) or the proton-coupled folate transporter (PCFT) (IC50 < 7 nM). AGF154 inhibited KB, IGROV1, and SKOV3 human tumor cells at subnanomolar concentrations, reflecting both FRα and PCFT uptake. AGF154 inhibited glycinamide ribonucleotide formyltransferase (GARFTase). In severe combined immunodeficient mice bearing SKOV3 tumors, AGF154 was efficacious. The selectivity of AGF154 for PCFT and for FRα and β over the ubiquitously expressed reduced folate carrier is a paradigm for selective tumor targeting.[1] |
别名 | AGF 154, AGF154, AGF-154 |
分子量 | 447.46 |
分子式 | C19H21N5O6S |
CAS No. | 1286279-90-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (122.92 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2348 mL | 11.1742 mL | 22.3484 mL | 55.8709 mL |
5 mM | 0.447 mL | 2.2348 mL | 4.4697 mL | 11.1742 mL | |
10 mM | 0.2235 mL | 1.1174 mL | 2.2348 mL | 5.5871 mL | |
20 mM | 0.1117 mL | 0.5587 mL | 1.1174 mL | 2.7935 mL | |
50 mM | 0.0447 mL | 0.2235 mL | 0.447 mL | 1.1174 mL | |
100 mM | 0.0223 mL | 0.1117 mL | 0.2235 mL | 0.5587 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Antifolate C2 1286279-90-0 Others AGF 154 AGF154 AGF-154 Antifolate C-2 Inhibitor inhibitor inhibit