TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.

Cat. No.	Product Name	CAS No.	Purity
TN2974	3-O-Methylquercetin tetraacetate 化合物 TN2974	1486-69-7	98%
TN2974	Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiv...
TN1764	Incensole acetate 因香酚乙酸酯	34701-53-6	98%
TN1764	Incensole acetate is a novel anti-inflammatory compound that inhibits NF-κB activation.
TN1235	3,4,5-Tricaffeoylquinic acid 3,4,5-三咖啡酰奎宁酸	86632-03-3	98%
TN1235	3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like rece...
TN1543	Cynaropicrin 菜蓟苦素	35730-78-0	98%
TN1543	Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to prevention of UVB-induced photo aging; it may be a potential a...
TN3219	7,8-Didehydrocimigenol 化合物 TN3219	150972-72-8	98%
TN3219	7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of ...
T11442	GNE684 化合物 T11442	2438637-64-8	98%
T11442	GNE684 是一种有效的受体相互作用蛋白 1(RIP1)抑制剂，对人类、小鼠与大鼠 RIP1 的平均Kiapp 值分别为 21 nM、189 nM 和 691 nM。
TN3708	Coronarin D 化合物 TN3708	119188-37-3	98%
TN3708	Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
TN5011	Shizukaol B 化合物 TN5011	142279-40-1	98%
TN5011	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
TN3779	De-O-methyllasiodiplodin 化合物 TN3779	32885-82-8	98%
TN3779	De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects on i...
TN2243	Sugiol 柳杉酚	511-05-7	98%
TN2243	Sugiol (10-Deoxoxanthoperol) 是一种枞烷二萜，可从台湾板栗树 (Calocedrus formosana) 的树皮中分离出来。Sugiol 具有抗炎活性，可有效减少脂多糖 (LPS) 刺激巨噬细胞后的活性氧 (ROS) 产生。
T2S0606	Bakkenolide A 蜂斗菜内酯A	19906-72-0	98%
T2S0606	Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
TN3298	8alpha-Hydroxyhirsutinolide 化合物 TN3298	1394156-45-6	98%
TN3298	8alpha-Hydroxyhirsutinolide shows anti-inflammatory activity, it inhibits TNF-α-induced NF-ÎºB activity with the IC(50) value of 1.9 uM.
TN4986	Selinidin 化合物 TN4986	19427-82-8	98%
TN4986	Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
T12985L	SPD304 化合物SPD304	869998-49-2	98%
T12985L	SPD304 是一种选择性 TNF-α 抑制剂，可阻断 TNF 与其受体的相互作用。 SPD304 在体外抑制 TNF 受体 1 与 TNF-α 结合的 IC50 为 22 µM。
TN4093	Galeopsin 化合物 TN4093	76475-16-6	98%
TN4093	Galeopsin shows potential anti-inflammatory activity by inhibiting proinflammatory cytokine TNF-α, it has anti-proliferative effect on several cancer cell lines....
TN2178	Sanggenone H 桑根酮H	86450-80-8	98%
TN2178	Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α² and inhibited the NF-κB nuclear translocation in LPS-stimulated m...
TN4190	Hedycoronen A 化合物 TN4190	1383441-73-3	98%
TN4190	Hedycoronen A and hedycoronen B have the potential anti-inflammatory benefits, they are potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, w...
TN4776	Physalin D 化合物 TN4776	54980-22-2	98%
TN4776	Physalin D shows antimalarial activity; it also exhibits a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H(37)Rv strain of 32 m...
TN4392	Koaburaside 化合物 TN4392	41653-73-0	98%
TN4392	Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have ...
TN2149	Reynosin 喘诺木烯内酯	28254-53-7	98%
TN2149	Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reci...