HCV Protease

NS2-3 protease (of hepatitis C virus, HCV) is an enzyme responsible for proteolytic cleavage between NS2 and NS3, which are non-structural proteins that form part of the HCV virus particle. NS3 protease of hepatitis C virus, on the other hand, is responsible for the cleavage of non-structural protein downstream. Both of these proteases are directly involved in HCV genome replication, that is, during the viral life-cycle that leads to virus multiplication in the host that has been infected by the virus.

Cat. No.	Product Name	CAS No.	Purity
TQ0030	Tomeglovir 托美洛韦	233254-24-5	98%
TQ0030	Tomeglovir is a potent anti-CMV agent, inhibiting the processing of viral DNA-concatemers (IC50s: 0.34/0.039 μM for HCMV and MCMV).
T71653	GS-9256 化合物 GS-9256	1001094-46-7	98%
T71653	GS-9256为选择性HCV NS3蛋白酶抑制剂，展现出优良的药代动力学特性及抗病毒活性。
T14095	ACH-806 化合物 T14095	870142-71-5	98%
T14095	ACH-806 is an NS4A antagonist. It can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM.
TN1703	Glycyrin 格里西轮	66056-18-6	98%
TN1703	Glycyrin, one of the main PPAR-gamma ligands of licorice, can significantly decrease the blood glucose levels of genetically diabetic KK-A(y) mice.
T12964	Sofosbuvir impurity I 化合物 T12964	T12964	98%
T12964	Sofosbuvir impurity I is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12956	Sofosbuvir impurity A 索非布韦杂质A	1496552-16-9	98%
T12956	Sofosbuvir impurity A is an diastereoisomer of Sofosbuvir. Sofosbuvir is anHCV RNA replication inhibitor ,with potent anti-hepatitis C virus activity.
TN4404	Ladanein 化合物 TN4404	10176-71-3	98%
TN4404	Ladanein is a phytochemicals inhibitor that is known to disrupt the interactions of core and other hepatitis C virus (HCV) proteins.Ladanein possesses free radic...
T14555	BI-1230 化合物 T14555	849022-32-8	98%
T14555	BI-1230 is a potent inhibitor of HCV NS3 protease, exhibiting efficacy in the low nanomolar range, and notably suppresses viral replication. This compound demons...
TN6732	Oenothein B 月见草素B	104987-36-2	98%
TN6732	Oenothein B 是一种聚（ADP-核糖）糖水解酶的特异性抑制剂。 Oenothein B 具有抗氧化、抗炎、抗真菌、抗 HCV 和抗肿瘤特性。
T16774	RO-9187 化合物 T16774	876708-03-1	98%
T16774	RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM).
T1188	Mizoribine 咪唑立宾	50924-49-7	99.98%
T1188	Mizoribine (NSC-289637) 是一种免疫抑制剂，抑制HCVRNA 复制，有抗 HCV 活性，IC50约为 100 μM。它抑制SARS-CoV 复制，对 SARS-CoV Frankfurt-1 和 SARS-CoV HKU39849 的 IC50分别为 3.5 μg/mL 和 16 μg/mL。
T5S1598	Mulberroside C 桑皮苷 C	102841-43-0	99.97%
T5S1598	Mulberroside C 是桑树中的主要生物活性成分之一，可抑制 HCV 复制，具有抗病毒活性。
T9577	HCV-IN-31 化合物HCV-IN-31	1998705-62-6	99.95%
T9577	HCV-IN-31 是一种HCV 抑制剂，EC50/EC95值为15.7 μM。
T22489	2'-MeCCPA 化合物2'-MeCCPA	205171-12-6	99.93%
T22489	2'-MeCCPA 是一种具有有效性和高选择性的 A1 腺苷受体 (A1AR) 激动剂，对 AR 的 K 值为 1.8 nM。2'-MeCCPA 抑制毛喉素刺激的腺苷酸环化酶活性，IC值为13.1 nM。2'-MeCCPA 具有镇痛活性，可用于研究 HCV 。
T6846	Vesatolimod 维沙莫德	1228585-88-3	99.92%
T6846	Vesatolimod (GS-9620) 是一种选择性 Toll 样受体 7 口服激动剂，EC50值为291 nM。
T4474	Asunaprevir 阿那匹韦	630420-16-5	99.92%
T4474	Asunaprevir (BMS-650032) 是一种有口服活性的 HCV NS3 蛋白酶抑制剂，IC50值为 0.2 nM-3.5 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。
T1822L	Clemizole hydrochloride 盐酸克立咪唑	1163-36-6	99.91%
T1822L	Clemizole hydrochloride 是一种 TRPC5通道的抑制剂。它还是一种 H1 组胺受体拮抗剂，抑制 HCV 复制。
T3334	Velpatasvir 维帕他韦	1377049-84-7	99.91%
T3334	Velpatasvir (GS-5816) 是一种的 HCV NS5A 抑制剂。它也是 SARS-CoV 3CLpro 的抑制剂，IC50为 2.16 μM。
T3810	Saikosaponin B2 柴胡皂苷 B2	58316-41-9	99.88%
T3810	Saikosaponin B2 是从柴胡根中分离得到的一种活性成分，可抑制 HCV 病毒感染的侵入，有抗癌作用。
T3001	Honokiol 和厚朴酚	35354-74-6	99.87%
T3001	Honokiol (NSC-293100) 是厚朴提取物的活性成分，靶向多种信号分子，具有抗氧化，抗炎，抗血管生成和抗癌活性。它可抑制 Akt 的激活并增强 ERK1/ERK2 的磷酸化。