Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat. No.	Product Name	CAS No.	Purity
TN1953	Morusinol 桑树醇	62949-93-3	98%
TN1953	Morusinol 是从桑树根皮中提取出的类黄酮。 Morusinol 具有抗血小板和抗癌活性，在体内抑制动脉血栓形成，通过诱导自噬、G2/M 细胞周期阻滞、抑制细胞侵袭和迁移以及靶向 Ras/MEK/ERK 通路发挥抗肿瘤活性。
T6769	Elaiophylin 洋橄榄叶素	37318-06-2	98%
T6769	Elaiophylin (Salbomycin) 是一种自噬抑制剂，在卵巢癌细胞中有抗肿瘤活性。它对 Plasmodium falciparum K1a 和 Trypanosoma brucei brucei GUTat 3.1 菌株具有抗原生动物活性，IC50 分别为 0.36 μM 和 0.45 μM。
T7162	R1487 Hydrochloride 化合物R1487 (Hydrochloride)	449808-64-4	98%
T7162	R1487 Hydrochloride (R1487(Hydrochloride)) 是一种可口服的高选择性 p38α 抑制剂，对 p38α 和 p38β 的Kd 值分别为 0.2 nM 和 29 nM。
TN4774	Physalin A 化合物 TN4774	23027-91-0	98%
TN4774	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
T9207	GW406108X 化合物GW406108X	1644443-92-4	98%
T9207	GW406108X (GW108X) 是一种 Kif15 抑制剂，在 ATPase 测定中的 IC50 为 0.82 uM。它也是一种 ULK1 激酶抑制剂，pIC50 值为 6.37(427 nM)，可阻断自噬通量。
T10607	BRD5631 化合物 T10607	2446154-91-0	98%
T10607	BRD5631 是一种自噬 (autophagy) 增强剂，通过与 mTOR 无关的通路来增强自噬。BRD5631 能够影响先前与自噬相关的几种细胞疾病表型，包括蛋白聚集、细胞存活、细菌复制和炎性因子的产生。BRD5631可以作为一种有价值的工具，用于研究自噬在细胞稳态和疾病中的作用。
T6178	PTC-209 hydrobromide 化合物PTC-209 HBr	1217022-63-3	98%
T6178	PTC-209 hydrobromide (PTC-209 HBr) 是一种特定的BMI-1抑制剂，能不可逆转地损害结直肠癌起始细胞，也可损害肿瘤微环境，有抗骨髓瘤活性。它在 HEK293T 细胞系中的IC50为 0.5 μM。
T36113	Cobaltic Protoporphyrin IX chloride 原卟啉氯化钴	102601-60-5	98%
T36113	Cobaltic Protoporphyrin IX chloride (CoPP)是一种有效的血红素加氧酶 1(HO-1)诱导剂，具有抗病毒活性，通过诱导 I 型 IFN 反应来抑制甲型流感病毒(IAV)感染。
TN4064	Flavoglaucin 化合物 TN4064	523-73-9	98%
TN4064	Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
TN3144	6,4'-Dihydroxy-7-methoxyflavanone 6,4'-二羟基-7-甲氧基二氢黄酮	189689-32-5	98%
TN3144	6,4'-Dihydroxy-7-methoxyflavanone 是一种从 Dalbergia odorifera T. Chen (Leguminosae) 的心材中分离出来的生物活性化合物，具有抗氧化、抗炎和神经保护作用。 6,4'-二羟基-7-甲氧基黄烷酮可用于治疗破骨性骨病如骨质疏松症、类风湿性关节炎和牙周病的...
TN4420	Latifolin 化合物 TN4420	10154-42-4	98%
TN4420	Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-ÎºB activation via Nrf2-mediated heme oxygenase-1 expression. Latifol...
T15378	Gemcitabine elaidate 反油酸吉西他滨	210829-30-4	98%
T15378	Gemcitabine elaidate (CP-4126) 是 Gemcitabine 的亲脂性前药。它通过酯酶转化为 Gemcitabine 以被磷酸化。它具有抗肿瘤活性。
T15412	GPP78 化合物 T15412	1202580-59-3	98%
T15412	GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y ...
TN4213	Hirsutenone 化合物 TN4213	41137-87-5	98%
TN4213	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
T37031	Quinacrine mustard hydrochloride 奎纳克林芥末盐酸盐	4213-45-0	98%
T37031	Quinacrine mustard hydrochloride 是一种荧光染料,也是一种多环芳香剂，可作为诱变剂诱导细菌的突变体。Quinacrine mustard hydrochloride 能选择性地与腺嘌呤-胸腺嘧啶（AT）碱基对结合，而不是与鸟嘌呤-胞嘧啶（GC）碱基对结合，诱导细胞周期停滞在 G2/M ...
T19188	ALLO-1 化合物 T19188	37468-32-9	98%
T19188	ALLO-1 is a crucial autophagy receptor responsible for facilitating the formation of autophagosomes around paternal organelles. It directly interacts with the wo...
T35329	EAD1 化合物 EAD1	1644388-26-0	98%
T35329	EAD1是一种有效的自噬（autophagy）抑制剂，在 BxPC3细胞中 IC50为5.8 μM。它在肺癌和胰腺癌细胞中具有抗增殖活性。
T6806	Cilengitide TFA 化合物Cilengitide trifluoroacetate	199807-35-7	98%
T6806	Cilengitide TFA 是一种选择性的 αvβ3和 αvβ5受体整合素抑制剂，IC50分别为 4 nM 和 79 nM。对 GP IIb/IIIa 的选择性约为 10 倍。
TN4778	Physalin H 化合物 TN4778	70241-09-7	98%
TN4778	Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induc...
TN3726	Cudraflavone B 化合物 TN3726	19275-49-1	98%
TN3726	Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...