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Cat. No. | Product Name | Target | Signaling Pathways |
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T4497 |
Amifampridine
3,4-Pyridinediamine,Pyridine-3,4-Diamine,阿米吡啶,3,4-Diaminopyridine |
Others | Others |
Amifampridine (3,4-Diaminopyridine) 可用于罕见肌肉疾病的研究。 | |||
T11990 |
Meclofenamic acid
甲氯芬那酸,Meclofenamate |
Others; Gap Junction Protein | Cytoskeletal Signaling; Others |
Meclofenamic acid (Meclofenamate) 是一种非特异性 gap-junction 阻滞剂和特异性脂肪量和肥胖相关 (FTO) 酶抑制剂。 Meclofenamic acid 具有抗炎活性。 | |||
T23497 |
UK 78282 hydrochloride
|
Potassium Channel | Membrane transporter/Ion channel |
UK 78282 hydrochloride,一种新型有效且具有选择性的 Kv1.3 阻滞剂。UK 78282 hydrochloride 抑制 Kv1.3 电压门控钾通道,抑制人 T 细胞活化。 | |||
T12786 |
RY785
|
Potassium Channel | Membrane transporter/Ion channel |
RY785 是电压门控钾 (KV2)通道的选择性抑制剂, KV2.2 的 IC50为 0.05 μM。它在缓解疼痛方面具有研究价值。 | |||
T7502 |
PF 05089771 tosylate
|
Sodium Channel | Membrane transporter/Ion channel |
PF 05089771 tosylate 是口服有效的、选择性的Nav1.7丙烯酰胺抑制剂。PF 05089771 tosylate 具有用于疼痛和糖尿病神经性疾病的研究。 | |||
T1496 |
Amiodarone hydrochloride
盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone |
Potassium Channel; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Amiodarone hydrochloride (Amiodarone HCl) 是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的 ERK1/2和 p38 MAPK 信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。 | |||
T22925 |
Linopirdine dihydrochloride
|
Others | Others |
KV7 (KCNQ) voltage-gated potassium channels blocker | |||
T16815 |
RY796
|
Others | Others |
RY796 is an effective and selective inhibitor of voltage-gated potassium channel (IC50s: 0.25 μM and 0.09 μM for KV2.1 and KV2.2). | |||
T11787 | Kv3 modulator 1 | Others | Others |
Kv3 modulator 1 is a promising compound for the treatment of inflammatory pain. As a modulator of Kv3 voltage-gated potassium channels, Kv3 modulator 1 exhibits potential therapeutic properties in this indication. | |||
T80980 |
Tityustoxin-Kα
TsTx-Kα |
||
Tityustoxin-Kα (TsTx-Kα) 为钾电压门控通道抑制剂,表现出对培养的海马神经元持续外向电流的剂量依赖性阻断作用。 | |||
T80064 |
Dendrotoxin-I
DTX-I |
Potassium Channel | Membrane transporter/Ion channel |
Dendrotoxin-I是一种高效的K+通道阻滞剂,特异性针对KV1.1和KV1.2电压门控钾通道亚基。该化合物为从Dendroaspis蛇毒中提取的神经毒素。 | |||
T62770 | DAD | ||
DAD 是一种离子通道阻滞剂 (可阻断电压门控的钾离子通道)。DAD 也是一种对可见光作出响应的第三代光电开关。DAD 能够用于研究视觉功能。 | |||
T63684 | DAD dichloride | ||
DAD dichloride 是离子通道阻滞剂,能够阻断电压门控的钾离子通道 (potassium channels))。DAD dichloride 是一种对可见光作出响应的第三代光电开关。DAD dichloride 能够用于研究视觉功能。 | |||
T80497 |
KTX-Sp2
|
Potassium Channel | Membrane transporter/Ion channel |
KTX-Sp2为钾通道毒素,能高效阻断三种外源电压门控钾通道Kv1.1、Kv1.2和Kv1.3。该化合物还能抑制内源性Kv1.3通道,降低Jurkat T细胞内Ca2+信号并抑制其活化后的IL-2分泌。 | |||
T80851 |
VSTx-3
Kappa-TRTX-Gr4a,κ-Theraphotoxin-Gr4a,Voltage sensor toxin 3,Peptide F |
||
VSTx-3是KV通道阻断剂,同时也是TTX敏感钠通道尤其是NaV1.8通道的有效阻断剂。具体而言,其对hNaV1.3通道的IC50为0.19 μM,对hNaV1.7通道的IC50为0.43 μM,对hNaV1.8通道的IC50为0.77 μM。 | |||
T75792 |
Huwentoxin XVI TFA
|
||
Huwentoxin XVI TFA,一种来自鸟蛛 Ornithoctonus huwena 的止痛剂,一种高度可逆和选择性的哺乳动物 N 型钙通道 (N-type calcium channel) (IC50约为 60 nM) 拮抗剂。Huwentoxin XVI TFA 对电压门控的 T 型钙通道,钾通道或钠通道没有影响。 | |||
T21819 |
Psora 4
|
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Psora-4,一种有效的Kv1.3(电压门控钾通道)选择性抑制剂,EC50值为3 nM。该化合物显示出免疫抑制活性,在体外能够抑制人类及大鼠髓鞘组织特异性效应记忆T细胞的增殖,展现出治疗自身免疫性疾病的潜力。 | |||
T80426 |
Jingzhaotoxin-IX
|
Sodium Channel | Membrane transporter/Ion channel |
Jingzhaotoxin-IX是由35个氨基酸残基组成的C端酰胺化神经毒素。该化合物既抑制电压门控钠通道(包括河豚毒素抗性和河豚毒素敏感亚型)又抑制Kv2.1通道,但对延迟整流钾通道Kv1.1、1.2和1.3无效。 | |||
T80528 |
Ssm spooky toxin
SsTx Toxin |
Potassium Channel | Membrane transporter/Ion channel |
Ssm Spooky Toxin是从Scolopendra mutilans中分离出的化合物,其特点是有效抑制KCNQ(电压门控钾通道家族7)通道,表现出对血液和呼吸系统的致命毒性。Ssm Spooky Toxin对Kv7.4、Kv1.3和Shal通道的IC50值分别为2.8 μM、5.26 μM和0.1-0.3 M,且能够通过针对T细胞中的KV1.3通道抑制细胞因子的产生,在蜈蚣的循环系统中起着关键作用。 | |||
T36482 |
Lamotrigine isethionate
|
||
Water-soluble salt of lamotrigine . Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents. Leach et al (1991) Neurochemical and behavioral aspects of lamotr. Epilepsia 32 S4 PMID:1685439 |Smith and Meldrum (1995) Cardioprotective effect of lamotr. after focal ischemia in rats. Stroke 26 117 PMID:7839380 |Zona and Avoli (1997) Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 38 522 PMI... | |||
T35426 |
β-Defensin-1 (human) (trifluoroacetate salt)
|
||
β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth ofB. adolescentis,L. acidophilus,B. breve,B. vulgatus,L. fermentum,B. longum, andS. thermophilusin an antimicrobial radial diffusion assay.2β-Defensin-1 also inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius, and of susceptibleM. tuberculosisH37Rv but no... | |||
T83739 |
Myr-Tat-CBD3 TFA
Myr-Tat-Calcium Channel-binding Domain 3,N-myristate-Tat-CBD3 |
||
Myr-Tat-CBD3是一种抑制N型电压门控钙通道Cav2.2与collapsin response mediator protein 2 (CRMP2)之间的蛋白-蛋白相互作用的抑制剂。在10 µM的浓度下,该化合物能够约81%地抑制Cav2.2-CRMP2相互作用,并在大鼠初级背根神经节(DRG)神经元中抑制钾诱导的钙流入(IC50约为2.8 µM)。在20 µM的浓度下,Myr-Tat-CBD3能抑制钙电流,但不影响钠电流,在初级DRG神经元中表现出这种特性。经过脊髓内给药,myr-Tat-CBD3(20 µg/5 µl)能够防止大鼠脚掌撤回潜伏期因carrageenan注射而减少。此外,Myr-Tat-CBD3减少大鼠因线索引起的寻求可卡因行为的复发。 | |||
T36803 |
AAQ chloride
|
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Photoswitchable Kv channel blocker (IC50 values are 2 and 64 μM at 500 nm and 380 nm respectively). Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Exhibits minimal activity at Nav1.2 and L-type Ca2+ channels. Stimulates action potential firing of hippocampal neurons in vitro at 500 nm and restores visual responsiveness in blind mice at 380 nm. Fortin et al (2008) Photochemical control of endogenous ion channels and cellular excitability. Nat.Methods 5 331 PMID:1831... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T27564 |
Hymenidin
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Hymenidin是一种从冲绳海绵Hymeniacidon sp。中分离出的生物碱,是一种5-羟色胺能受体拮抗剂和电压门控钾通道抑制剂,具有潜在的抗原生动物作用,可选择性结合 FOXO1 DNA ,可降低去极化诱导的细胞钙升高。 |