Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40428L |
TfR-T12 acetate
TfR-T12 acetate (344618-30-0 Free base) |
Others | Others |
TfR-T12 acetate 是一种与转铁蛋白受体 (TfR) 结合的肽,随后被内化到表达 TfR 的细胞中。 | |||
T34973 |
Tyrphostin 8
4-Hydroxybenzylidenemalononitrile |
EGFR; GTPase | Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) 是一种有效的 GTP 酶抑制剂,对 EGFR 激酶有抑制作用, IC50 值为 560 μM。Tyrphostin 8 可抑制蛋白丝氨酸/苏氨酸钙调磷酸酶 (IC50=21 μM),增强 Caco-2 细胞中转铁蛋白受体介导的转吞作用,并增加口服胰岛素 - 转铁蛋白的降血糖作用。 | |||
T80622 |
Trontinemab
|
||
Trontinemab为一种双特异性人源IgG1-κ抗体,靶向Aβ前体蛋白(APP)与转铁蛋白受体p90, CD71 (TFRC)。该抗体主要应用于阿兹海默症研究。 | |||
T78022 |
Transferrins
|
||
Transferrin,一种血浆糖蛋白,作为转铁蛋白受体的特异性配体,能够结合并调控铁离子的运输。 | |||
T40428 |
TfR-T12
TfR-T12 |
||
TfR-T12 is a transferrin receptor (TfR) binding peptide that can penetrate the blood-brain barrier (BBB), exhibiting a high binding affinity within the nanomolar (nM) range. | |||
T15135L |
Direct Black 38 free acid
NSC8679,Ferristatin II |
Others | Others |
Ferristatin II (Direct Black 38 free acid) is a polysulphonated dye and promotes the degradation of transferrin receptor-1 in vitro and in vivo. | |||
T78374 |
TfR-T12 TFA
|
||
TfR-T12 TFA为能穿透血脑屏障的转铁蛋白受体(TfR)结合肽,展现出纳摩尔级的结合活性。 | |||
T78014 |
HAIYPRH hydrochloride
|
||
HAIYPRH hydrochloride为一种能特异性结合转铁蛋白受体(TfR)的靶向配体,可促进纳米载体穿越血脑屏障的介导转运。 | |||
T81573 |
Pabinafusp alfa
JR-141 |
||
Pabinafusp alfa (JR-141) 是由Iduronate 2-sulfatase和抗人转铁蛋白受体抗体结合而成的转铁蛋白受体靶向抗体。它具备穿透血脑屏障的能力,可防止粘多糖病II型(MPS II)小鼠中枢神经系统中硫酸肝素(HS)的积累。此外,Pabinafusp alfa能够促进小鼠的学习能力,并抑制中枢神经系统神经元的损伤。 | |||
T26639 |
Ap44mSe
|
||
Ap44mSe is a potent and selective antitumor agent. Ap44mSe effectively depletes cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regula |