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Search Results for " thymine "

25

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TNU0352	1-beta-D-Arabinofuranosylthymine Thymine 1-β-D-arabinofuranoside,Spongothymidine	Apoptosis	Apoptosis
	1-beta-D-Arabinofuranosylthymine (Thymine 1-β-D-arabinofuranoside) is a purine nucleoside analog. Purine nucleoside analogs have a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing apoptosis.1-beta-D-Arabinofuranosylthymine's anticancer mechanism is dependent on the inhibition of DNA synthesis.1-beta-D-Arabinofuranosylthymine is a purine nucleoside analog.
T19086	1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine	Others	Others
	1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine is a bicyclic nucleoside.
TNU1548	(R)-DMT-glycidol-thymine
	(R)-DMT-glycidol-thymine is a Nucleoside Derivative - Acyclic nucleoside.
TNU0641	7’-OH-N-trityl morpholino thymine
	Morpholino nucleoside
TNU1336	1-(alpha-L-Threofuranosyl)thymine
	1-(alpha-L-Threofuranosyl)thymine is a Nucleoside Derivative - L-nucleoside.
T8648	6-AZATHYMINE	Nucleoside Antimetabolite/Analog; Influenza Virus; DNA/RNA Synthesis; Antibacterial	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	6-Azathymine 是胸腺嘧啶的 6-氮类似物，是 D-3-氨基异丁酸酯-丙酮酸氨基转移酶抑制剂，具有抗菌和抗病毒活性，可抑制DNA 的生物合成。
TNU1447	7'-O-DMT-morpholino thymine
	7'-O-DMT-morpholino thymine is a Nucleoside Derivative - Morpholino nucleoside.
TNU1337	1-(3’-O-[4,4’-Dimethoxytrityl]-alpha-L-threofuranosyl)-thymine
	Nucleoside Derivatives - L-Nucleosides; Protected nucleosides w/NH2/OH open
TNU0790	1-(3-beta-Amino-2,3-dideoxy-beta-D-threopenta-furanosyl)thymine
	3’-N-modified nucleoside
TNU0788	1-(3-beta-Azido-2,3-dideoxy-5-O-trityl-beta-D-threopenta-furanosyl)thymine
	Azido-nucleoside; 3’-N-modified nucleoside
TNU1420	1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine 3'-CE phosphoramidite
	1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine 3'-CE phosphoramidite is a Nucleoside Phosphoramidite.
TNU0789	3-epi-Azido-3-deoxythymidine
	3’-N-modified nucleoside; Azido-nucleoside
TNU1607	DMTr-TNA-5MeU-amidite
	DMTr-TNA-5MeU-amidite is a Nucleoside Phosphoramidite.
T29896	alpha-Glutamylthymine
	alpha-Glutamylthymine is a hypermodified base for DNA.
T38813	6-Azathymine acid
	6-Azathymine acid is a metabolite derived from Pymetrozine, a potent insecticide known for its effectiveness against plant-sucking insects, specifically aphids and whiteflies. Pymetrozine's neuroactivity disrupts the feeding behavior of these pests, making it a valuable tool in protecting various crops, including vegetables, cotton, field crops, and fruits.
TNU0159	FMAU 2'-Deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine	Apoptosis	Apoptosis
	FMAU (2'-Deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine) is a thymine nucleoside analog with insertional activity on replicating DNA.FMAU can be used to label cells and track DNA synthesis.
T2627	Nolatrexed dihydrochloride 盐酸诺拉曲塞,Thymitaq,AG 337	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Nolatrexed dihydrochloride (Thymitaq) 是一种非竞争性的胸苷酸合酶抑制剂，能够在癌细胞 S 期诱导细胞周期停滞，具有抗癌活性。它与该酶的叶酸辅因子结合位点相互作用，对人胸苷酸合酶的Ki 值为 11 nM。
T19151	5-Chloro-2'-deoxyuridine 5-Chlorodeoxyuridine,5-氯-2-脱氧尿嘧啶核苷,CldU	Others	Others
	5-Chloro-2'-deoxyuridine (5-Chlorodeoxyuridine) 是胸腺嘧啶的类似物，可用于次氯酸对 DNA 和 DNA 前体的破坏作用的研究。
T19827	DAPI Dihydrochloride FxCycle Violet,4',6-二脒基-2-苯基吲哚二盐酸盐,4',6-diamidino-2-phenylindole	Others	Others
	DAPI Dihydrochloride (FxCycle Violet) 是一种可渗透细胞的荧光探针，通过结合在富含 A-T 的 DNA 序列的小树林中，用于染色 DNA 和染色体，优先选择富含腺嘌呤和胸腺嘧啶的 DNA。
T1349	5-Fluorouridine	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	5-Fluorouridine 是一种 5-fluorouracil 的代谢物，具有抗癌作用。它对 L1210 细胞的生长具有细胞毒性作用，其作用的 IC50值为 2 nM。它能抑制人结肠癌细胞 rRNA 的合成。
T25286	DANP
	DANP is a bulge base recognition probe. It is a potent and specific ligand of the single cytosine and thymine bulges with exclusively 1:1 stoichiometry.
T70462	Pibrozelesin
	Pibrozelesin is a water-soluble derivative of duocarmycin B2 that alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.
T40345	AV-153
	AV-153 is a 1,4-dihydropyridine derivative with antimutagenic properties. It intercalates into DNA at single strand breaks, resulting in reduced DNA damage and stimulation of DNA repair in human cells in vitro. AV-153 also interacts with thymine and cytosine and influences poly(ADP)ribosylation. Moreover, AV-153 exhibits anti-cancer activity.
T37031	Quinacrine mustard hydrochloride Quinacrine mustard HCl	Autophagy	Autophagy
	Quinacrine mustard hydrochloride 是一种荧光染料,也是一种多环芳香剂，可作为诱变剂诱导细菌的突变体。Quinacrine mustard hydrochloride 能选择性地与腺嘌呤-胸腺嘧啶（AT）碱基对结合，而不是与鸟嘌呤-胞嘧啶（GC）碱基对结合，诱导细胞周期停滞在 G2/M 期。Quinacrine mustard (hydrochloride) 已被用于标记移相染色体，以通过自动放射摄影技术进行核型分析。
T60649	AV-153 free base
	AV-153 free base 是一种 1,4-二氢吡啶(1,4-DHP) 衍生物。AV-153 free base 是一种抗诱变剂，具有抗癌活性。AV-153 free base 可以与胞嘧啶和胸腺嘧啶相互作用，并影响聚 (ADP) 核糖基化。在体外实验中，AV-153 free base 在 DNA 的单链断裂处插入到 DNA 并减少 DNA 损伤，刺激 DNA 修复。

化合物

1-beta-D-Arabinofuranosylthymine

Cat.No: TNU0352

Synonym: Thymine 1-β-D-arabinofuranoside,Spongothymidine

Target: Apoptosis

1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine

Cat.No: T19086

Target: Others

(R)-DMT-glycidol-thymine

Cat.No: TNU1548

7’-OH-N-trityl morpholino thymine

Cat.No: TNU0641

1-(alpha-L-Threofuranosyl)thymine

Cat.No: TNU1336

Cat.No: T8648

Target: Nucleoside Antimetabolite/Analog, Influenza Virus, DNA/RNA Synthesis, Antibacterial

7'-O-DMT-morpholino thymine

Cat.No: TNU1447

1-(3’-O-[4,4’-Dimethoxytrityl]-alpha-L-threofuranosyl)-thymine

Cat.No: TNU1337

1-(3-beta-Amino-2,3-dideoxy-beta-D-threopenta-furanosyl)thymine

Cat.No: TNU0790

1-(3-beta-Azido-2,3-dideoxy-5-O-trityl-beta-D-threopenta-furanosyl)thymine

Cat.No: TNU0788

1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine 3'-CE phosphoramidite

Cat.No: TNU1420

3-epi-Azido-3-deoxythymidine

Cat.No: TNU0789

DMTr-TNA-5MeU-amidite

Cat.No: TNU1607

alpha-Glutamylthymine

Cat.No: T29896

6-Azathymine acid

Cat.No: T38813

Cat.No: TNU0159

Synonym: 2'-Deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine

Target: Apoptosis

Nolatrexed dihydrochloride

Cat.No: T2627

Synonym: 盐酸诺拉曲塞,Thymitaq,AG 337

Target: DNA/RNA Synthesis

5-Chloro-2'-deoxyuridine

Cat.No: T19151

Synonym: 5-Chlorodeoxyuridine,5-氯-2-脱氧尿嘧啶核苷,CldU

Target: Others

DAPI Dihydrochloride

Cat.No: T19827

Synonym: FxCycle Violet,4',6-二脒基-2-苯基吲哚二盐酸盐,4',6-diamidino-2-phenylindole

Target: Others

5-Fluorouridine

Cat.No: T1349

Target: Others, DNA/RNA Synthesis

Cat.No: T25286

Cat.No: T70462

Cat.No: T40345

Quinacrine mustard hydrochloride

Cat.No: T37031

Synonym: Quinacrine mustard HCl

Target: Autophagy

AV-153 free base

Cat.No: T60649

Cat. No.	Product Name	Target	Signaling Pathways
TWO2759	Thymine 胸腺嘧啶,5-methyluracil	Others; Endogenous Metabolite	Metabolism; Others
	Thymine (5-methyluracil) 是 DNA 的四个碱基之一，在动物癌症模型中，能够作为5-氟尿嘧啶的靶标，其 Km=2.3 μM。
TN7153	1-(2-hydroxyethyl)thymine 1-(hydroxyethyl)thymine,2,4(1H,3H)-Pyrimidinedione, 1-(2-hydroxyethyl)-5-methyl-	Others	Others
	1-(2-hydroxyethyl)thymine (2,4(1H,3H)-Pyrimidinedione, 1-(2-hydroxyethyl)-5-methyl-) 是一种海洋来源的天然产物，存在于Zoanthus sp。
T5282	5-Methyluridine Ribothymidine,5-甲基尿甙,Thymine riboside	Others; Endogenous Metabolite	Metabolism; Others
	5-Methyluridine (Thymine riboside) 是发现于人体液中的内源性甲基化核苷。
T0532	5,6-Dihydro-5-methyluracil 5, 6-Dihydrothymine,二氢朐腺嘧啶,Dihydrothymine	Nucleoside Antimetabolite/Analog; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	5,6-Dihydro-5-methyluracil (Dihydrothymine) 是胸腺嘧啶的中间代谢产物之一，来源于动植物，浓度过高时会产生毒性。
T5255	5-Hydroxymethyluracil 5-(Hydroxymethyl)uracil,5-羟甲基脲嘧啶,Hydroxymethyl Uracil,a-Hydroxythymine	Others; Endogenous Metabolite	Metabolism; Others
	5-Hydroxymethyluracil (a-Hydroxythymine) 是一种氧化性 DNA 损伤的产物，能够增强或抑制细菌 RNA 聚合酶转录的潜在表观遗传标记。
T0069	Uracil	Others; Endogenous Metabolite	Metabolism; Others
	Uracil 是普遍存在的天然嘧啶衍生物，是 RNA 核酸中的四个碱基之一。
T7357	(S)-b-aminoisobutyric acid	Endogenous Metabolite	Metabolism
	(S)-b-aminoisobutyric acid 是由胸腺嘧啶和缬氨酸分解代谢得到的非蛋白质氨基酸。
T4711	2,4-Dihydroxypyrimidine-5-carboxylic acid 脲嘧啶-5-羧酸,Isoorotic acid,Uracil-5-carboxylic acid	Others; Endogenous Metabolite	Metabolism; Others
	2,4-Dihydroxypyrimidine-5-carboxylic acid (Isoorotic acid) 是内源性代谢产物的一种。
T4809	Pyrimidine 嘧啶,Metadiazine	Others; Endogenous Metabolite	Metabolism; Others
	Pyrimidine (Metadiazine) 是内源性代谢产物的一种。

天然产物

Cat.No: TWO2759

Synonym: 胸腺嘧啶,5-methyluracil

Target: Others, Endogenous Metabolite

1-(2-hydroxyethyl)thymine

Cat.No: TN7153

Synonym: 1-(hydroxyethyl)thymine,2,4(1H,3H)-Pyrimidinedione, 1-(2-hydroxyethyl)-5-methyl-

Target: Others

5-Methyluridine

Cat.No: T5282

Synonym: Ribothymidine,5-甲基尿甙,Thymine riboside

Target: Others, Endogenous Metabolite

5,6-Dihydro-5-methyluracil

Cat.No: T0532

Synonym: 5, 6-Dihydrothymine,二氢朐腺嘧啶,Dihydrothymine

Target: Nucleoside Antimetabolite/Analog, Endogenous Metabolite

5-Hydroxymethyluracil

Cat.No: T5255

Synonym: 5-(Hydroxymethyl)uracil,5-羟甲基脲嘧啶,Hydroxymethyl Uracil,a-Hydroxythymine

Target: Others, Endogenous Metabolite

Cat.No: T0069

Target: Others, Endogenous Metabolite

(S)-b-aminoisobutyric acid

Cat.No: T7357

Target: Endogenous Metabolite

2,4-Dihydroxypyrimidine-5-carboxylic acid

Cat.No: T4711

Synonym: 脲嘧啶-5-羧酸,Isoorotic acid,Uracil-5-carboxylic acid

Target: Others, Endogenous Metabolite

Cat.No: T4809

Synonym: 嘧啶,Metadiazine

Target: Others, Endogenous Metabolite

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