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Search Results for " sulfated "

23

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP2204L	CCK Octapeptide, non-sulfated acetate CCK Octapeptide, non-sulfated acetate(25679-24-7 Free base)	cholecystokinin	GPCR/G Protein
	CCK Octapeptide, non-sulfated acetate 是一种合成的胆囊收缩素脱硫酸肽。
T37205	CCK (26-31) (sulfated)
	CCK (26-31) is an N-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. The sulfated form of CCK (26-31) inhibits binding of [125I]CCK-33 to guinea pig cortical membranes by 21% when used at a concentration of 0.1 mM.
T37203	CCK (26-30) (sulfated)
	CCK (26-30) is an N-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. The sulfated form of CCK (26-30) inhibits binding of [125I]CCK-33 to guinea pig cortical membranes by 10% when used at a concentration of 0.1 mM.
T38645	Acetyl-Hirudin (54-65) (sulfated)
	Acetyl-Hirudin (54-65) (sulfated) directly binds to thrombin-rHCII(L444R) and hinders the interaction between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin, which stabilizes the complex.
T37204	CCK (26-31) (non-sulfated)
	CCK (26-31) is an N-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety.
T37206	CCK (27-33) (non-sulfated)
	CCK (27-33) is a C-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. Non-sulfated CCK (27-33) inhibits binding of [3H]naloxone in rat cerebellum membranes (IC50 = 4 uM) and inhibits electrically-stimulated contraction of isolated guinea pig ileum (IC50 = 17 uM), an effect that can be reversed by naloxone. Unlike sulfated CCK (27-33), the non-sulfated form does not reduce exploratory behavior in m...
T35583	Hirudin (54-65; non-sulfated) (trifluoroacetate salt)	Others	Others
	Hirudin (54-65; non-sulfated) is a desulfated peptide fragment of hirudin, an anticoagulant produced byH. medicinalis.1It inhibits fibrin clot formation induced by isolated bovine thrombin with an IC50value of 3.7 μM.2 1.Niehrs, C., Huttner, W.B., Carvallo, D., et al.Conversion of recombinant hirudin to the natural form by in vitro tyrosine sulfation. Differential substrate specificities of leech and bovine tyrosylprotein sulfotransferasesJ. Biol. Chem.265(16)9314-9318(1990) 2.Payne, M.H., Krste...
TP2204	Cholecystokinin Octapeptide, desulfated CCK Octapeptide, non-sulfated	Others	Others
	Non-sulfated form of the C-terminal octapeptide of CCK
T83485	[Thr28, Nle31]-Cholecystokinin (25-33), sulfated
	[Thr28, Nle31]-Cholecystokinin (25-33) 是一种具备CCK8所有生物活性的胆囊收缩素 (CCK) 类似物，表现出食欲抑制功效。它在胃肠道系统和中枢神经系统中担任激素和神经递质角色。此肽通过 Thr28 和 Nle31 的特殊替代，展现出在酸性条件下的高稳定性，并能抵抗空气氧化（防止蛋氨酸受损）。其主要构象特征为以Thr4为核心的γ转角和Gly5分隔的C末端螺旋片段。
T80119	Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)	Thrombin	Proteases/Proteasome
	Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) 是一种具有高亲和力的Hirugen类肽，其与凝血酶的KD值小于100 nM。作为抗血栓剂，它能有效抑制凝血酶诱导的纤维蛋白凝块生成，其IC50值为0.087 μM。
T39170	Cholecystokinin Octapeptide, desulfated TFA CCK Octapeptide, desulfated TFA,Cholecystokinin Octapeptide, desulfated TFA
	Cholecystokinin Octapeptide, desulfated TFA, is a synthetic octapeptide derived from Cholecystokinin (CCK) that has undergone desulfation.
TP1547	Caerulein, desulfated
	Caerulein, desulfated is the desulfurated form of Caerulein. Caerulein is a deceptide with the same five carboxy-terminal amino acids as gastrin and cholecystatin (CCK).
TP1377	Caerulein, desulfated TFA (20994-83-6 free base) Caerulein, desulfated TFA
	Caerulein, desulfated TFA is Caerulein after desulfurization.Caerulein is a deceptide with the same five carboxy-terminating amino acids as gastrin and cholecystatin (CCK)..
T6531	Heparin sodium salt 肝素钠,Sodium heparinate,Heparin sodium	Factor Xa; Thrombin; Autophagy	Autophagy; Metabolism; Proteases/Proteasome
	Heparin sodium salt (Sodium heparinate) 是一种抗凝血剂，可以干扰血凝过程中的多个环节。Heparin sodium salt 可以与抗凝血酶 III 可逆结合，加快凝血酶因子 IIa 和 Xa 的失活速度，从而发挥抗凝作用。
T25163	Bivittoside B	Others	Others
	Bivittoside B 是一种非硫酸化的六苷类化合物，从波氏海参中提取得到，具有抗真菌活性和潜在抗肿瘤活性。
T25162	Bivittoside A	Others	Others
	Bivittoside A 是一种非硫酸化的六苷类化合物，从波氏海参中提取得到，具有抗真菌活性和潜在抗肿瘤活性。
T37004	Estradiol 3-sulfate 17β-Glucuronide (potassium salt)	Others	Others
	Estradiol 3-sulfate is a sulfated form of the steroid hormone 17β-estradiol , and is common in fetal plasma and in the breast tissues of patients with mammary carcinoma. Sulfated estrogens, including estradiol 3-sulfate, can be converted back to the parent compound by sulfatases. Estradiol 3-sulfate 17β-glucuronide is a metabolite of estradiol 3-sulfate that has been modified by a UDP-glucuronosyltransferase. Glucuronidation of estrogens enhances their utilization by anion transporters, most com...
T37812	6-O-Sulfo-β-cyclodextrin (sodium salt)	Others	Others
	6-O-Sulfo-β-cyclodextrin is a sulfated cyclodextrin.1It has been used for the chiral separation of nadolol racemates by capillary electrophoresis. 1.Wang, F., Dowling, T., Bicker, G., et al.Electrophoretic chiral separation of pharmaceutical compounds with multiple stereogenic centers in charged cyclodextrin mediaJ. Sep. Sci.24(5)378-384(2001)
T35797	Lithocholic acid 3-sulfate disodium Sulfolithocholic acid disodium	Others	Others
	Lithocholic acid 3-sulfate disodium (Sulfolithocholic acid disodium) 可作为 RORgammat 配体，抑制 Th17 细胞分化。Lithocholic acid 3-sulfate disodium 是石胆酸（LCA）的硫酸化产物，可诱导细胞损伤。
T38283	Tetracosanoyl-sulfatide C24 3'-sulfo Galactosylceramide (d18:1/24:0)	Others	Others
	Tetracosanoyl-sulfatide is an endogenous sulfated glycolipid, which are also known as sulfatides . Tetracosanoyl-sulfatide is the major sulfatide in mature myelin in the central and peripheral nervous systems. Levels of Tetracosanoyl-sulfatide are elevated in plasma derived from patients with metachromatic leukodystrophy, a disorder characterized by arylsulfatase A deficiency, leading to sulfatide accumulation. Unlike C24:1 3'-sulfo galactosylceramide, it does not induce an immune response in mo...
T75518	Galactofucan	Others	Others
	Galactofucan (Fucogalactan) 是一种硫酸多糖。Galactofucan 可以从棕色海藻 Saccharina longicruris 中提取，具有抗凝血、抗肿瘤、抗血栓形成、抗炎、抗病毒等特性。Galactofucan 对 HSV-1和 HSV-2具有抗病毒活性，IC50值分别为 0.76 和 1.34 µg/mL 。Galactofucan 可用于癌症和炎症的研究。
T82151	Hyaluronan-binding peptide, biotin labeled
	Hyaluronan-binding peptide, biotin labeled 是通过 C 端 GGGSK 残基生物素化的透明质酸结合肽，能够干预 HA 与 CD44 受体的作用，并阻碍 T 细胞增殖。 HA 在细胞外基质和细胞表面广泛表达，参与多种生物过程，包括受精、胚胎发育、伤口修复、血管新生、炎症反应和肿瘤转移。
T36132	3β-OH-7-Oxocholenic Acid	Others	Others
	3β-OH-7-Oxocholenic acid is a bile acid.1 It is also a metabolite of 7β-hydroxy cholesterol in rats. Conjugated forms of 3β-OH-7-oxocholenic acid have been found in the urine of patients with Neimann-Pick disease type C.2,3 \|1. Norii, T., Yamaga, N., and Yamasaki, K. Metabolism of 7β-hydroxycholesterol-4-14C in rat. Steroids 15(3), 303-326 (1970).\|2. Alvelius, G., Hjalmarson, O., Griffiths, W.J., et al. Identification of unusual 7-oxygenated bile acid sulfates in a patient with Niemann-Pick dise...

化合物

CCK Octapeptide, non-sulfated acetate

Cat.No: TP2204L

Synonym: CCK Octapeptide, non-sulfated acetate(25679-24-7 Free base)

Target: cholecystokinin

CCK (26-31) (sulfated)

Cat.No: T37205

CCK (26-30) (sulfated)

Cat.No: T37203

Acetyl-Hirudin (54-65) (sulfated)

Cat.No: T38645

CCK (26-31) (non-sulfated)

Cat.No: T37204

CCK (27-33) (non-sulfated)

Cat.No: T37206

Hirudin (54-65; non-sulfated) (trifluoroacetate salt)

Cat.No: T35583

Target: Others

Cholecystokinin Octapeptide, desulfated

Cat.No: TP2204

Synonym: CCK Octapeptide, non-sulfated

Target: Others

[Thr28, Nle31]-Cholecystokinin (25-33), sulfated

Cat.No: T83485

Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)

Cat.No: T80119

Target: Thrombin

Cholecystokinin Octapeptide, desulfated TFA

Cat.No: T39170

Synonym: CCK Octapeptide, desulfated TFA,Cholecystokinin Octapeptide, desulfated TFA

Caerulein, desulfated

Cat.No: TP1547

Caerulein, desulfated TFA (20994-83-6 free base)

Cat.No: TP1377

Synonym: Caerulein, desulfated TFA

Heparin sodium salt

Cat.No: T6531

Synonym: 肝素钠,Sodium heparinate,Heparin sodium

Target: Factor Xa, Thrombin, Autophagy

Cat.No: T25163

Target: Others

Cat.No: T25162

Target: Others

Estradiol 3-sulfate 17β-Glucuronide (potassium salt)

Cat.No: T37004

Target: Others

6-O-Sulfo-β-cyclodextrin (sodium salt)

Cat.No: T37812

Target: Others

Lithocholic acid 3-sulfate disodium

Cat.No: T35797

Synonym: Sulfolithocholic acid disodium

Target: Others

Tetracosanoyl-sulfatide

Cat.No: T38283

Synonym: C24 3'-sulfo Galactosylceramide (d18:1/24:0)

Target: Others

Cat.No: T75518

Target: Others

Hyaluronan-binding peptide, biotin labeled

Cat.No: T82151

3β-OH-7-Oxocholenic Acid

Cat.No: T36132

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T40416	D-Dimannuronic acid	Others	Others
	D-Dimannuronic acid, derived from brown algae, is an alginate extract employed in the synthesis of sulfated polymannuronate (SPMG)-derived oligosaccharides.
T38179	C16 3'-sulfo Galactosylceramide (d18:1/16:0) C16 3'-sulfo Galactosylceramide (d18:1/16:0)	Others	Others
	C16 3'-sulfo Galactosylceramide (d18:1/16:0)是硫酸盐类糖脂的一种。C16 3'-sulfo Galactosylceramide (d18:1/16:0)是在猪脑和血浆中发现的一种比较丰富的硫化物，在小鼠的整个发育过程中会有所减少。C16 3'-sulfo Galactosylceramide (d18:1/16:0)在体外可抑制视网膜神经节细胞生长。C16 3'-sulfo Galactosylceramide (d18:1/16:0)已被用作量化大鼠小脑和多发性硬化症患者分离的白质中的硫化物的参照物。

天然产物

D-Dimannuronic acid

Cat.No: T40416

Target: Others

C16 3'-sulfo Galactosylceramide (d18:1/16:0)

Cat.No: T38179

Synonym: C16 3'-sulfo Galactosylceramide (d18:1/16:0)

Target: Others

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