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33

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T41302	Itaconate-alkyne ITalk	Others	Others
	Itaconate-alkyne (ITalk) 是一种生物正交探针，用于对炎症性巨噬细胞中的衣康酸进行定量和位点特异性化学蛋白质组学分析，并能够对其直接靶标进行生化评估和蛋白质组学分析。
T20456	5-Chlorovaleronitrile AI3 20151,5-氯戊腈,AI3-20151,AI320151	Others	Others
	5-Chlorovaleronitrile (AI320151) 可用作定量结构毒性模型来预测水生毒性。
T16537	Pimonidazole	Others	Others
	Pimonidazole 是缺氧标记物，能够与大分子的共价结合或被还原形成还原性代谢物后在缺氧细胞中积累，可用于定性和定量评估肿瘤缺氧。它可用于瘤内缺氧和细胞增殖的补充性研究。
T15543	IA-Alkyne N-Hex-5-ynyl-2-iodo-acetamide,Iodoacetamide-alkyne	TRP/TRPV Channel	Membrane transporter/Ion channel
	IA-Alkyne (Iodoacetamide-alkyne) 是TRP 通道 (TRPC) 的激动剂，有用于呼吸道感染相关疾病研究的潜力。IA-Alkyne 可以用于开发同位素标记的探针，在定量的半胱氨酸反应分析 (cysteine-reactivity)有应用的价值。
TP1168	N-Formyl-Met-Leu-Phe-Lys fMLFK	Others	Others
	N-Formyl-Met-Leu-Phe-Lys (fMLFK) 是一种多肽，是选择性FPR1激动剂，作用于 FPR1(IC50:3.5 nM)，FPR2(IC50:6.7 nM) 和 FPR2-D2817.32G(IC50:0.88 nM) 。
T16536	Pimonidazole hydrochloride
	Pimonidazole hydrochloride 通过与大分子共价结合或在其硝基还原后形成还原性代谢物在缺氧细胞中积累。可用于肿瘤缺氧的定性和定量评估。它是一种新型的缺氧标志物，用于肿瘤缺氧和肿瘤细胞增殖的互补研究。
T66518	BODIPY-FL BDP FL acid
	BODIPY-FL (BDP FL acid) 是一种广谱且有效的荧光染料，可用于标记探针或引物，是一种基于荧光猝灭的定量检测特定 DNA/RNA 的化合物。BODIPY-FL 标记的单萜可用于检测革兰氏阳性和革兰氏阴性细菌的特征和致病真菌。
T10956	Dansyl glutathione DNS-glutathione	Others	Others
	Dansyl glutathione is a capture agent used for quantitative assessment and identification of reactive metabolites.
T36217	19-hydroxy Cholesterol
	19-hydroxy Cholesterol is formed during metabolic oxidation of cholesterol. It has been used as an internal standard for the quantitative determination of sterols by mass spectroscopic analysis.[1]
T25902	Ota-vasotocin OVTA
	Ota-vasotocin is a ligand utilized in quantitative receptor autoradiography for oxytocin receptors.
T34079	Pirbuterol Acetate pirbuterol sulfate,EINECS 265-862-4,Maxair,Pirbuterol acetate (USAN)
	Pibuterol Acetate is a short-acting beta-2 adrenergic receptor agonist with bronchiectasis and is used as a respiratory activated quantitative inhaler in the treatment of asthma.
T25773	Mal-RP MalRP,Mal RP
	Mal-RP is a quantitative chemical probe for live-cell labeling and imaging of proteins that are sensitive to redox modifications.
T82468	Endotoxin Substrate
	Endotoxin Substrate (Boc-LGR-pNA) 为显色底物，专用于内毒素定量分析。
T39191L	DSTYSLSSTLTLSK acetate DSTYSLSSTLTLSK acetate (177792-42-6 Free base)	Others	Others
	DSTYSLSSTLTLSK acetate 是可以用于英夫利昔单抗定量检测的人通用肽。
T39191	DSTYSLSSTLTLSK
	DSTYSLSSTLTLSK is a generic human peptide and can be used for infliximab quantitative detection. Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α.
TD0086	ROX Reference Dye
	ROX Reference Dye was designed to standardize fluorescent reporter gene signals in real-time quantitative PCR or RT-PCR
T39521	LEESGGGLVQPGGSMK
	LEESGGGLVQPGGSMK, a proteolysis peptide, is a constituent of Infliximab, a chimeric monoclonal IgG1 antibody that selectively binds to TNF-α. It can be employed for quantitative assessment of Infliximab.
T40674	Ioxaglic acid 碘克沙酸,P-286
	Ioxaglic acid (P-286) is a negatively charged contrast agent commonly utilized as an inverse indicator for glycosaminoglycan (GAG) in computed tomography (CT). This compound is valuable for imaging human osteoarthritic cartilage, enabling the quantitative assessment of glycosaminoglycan content.
T76209	DSTYSLSSTLTLSK TFA
	DSTYSLSSTLTLSK TFA 是用于 Infliximab (Avakine) 定量检测的通用肽。Infliximab (Avakine) 是一种嵌合单克隆IgG1抗体，能特异性地结合到 TNF-α。
T36091	LEESGGGLVQPGGSMK acetate
	LEESGGGLVQPGGSMK acetate is a proteolysis peptide found in Infliximab, a chimeric monoclonal IgG1 antibody. It serves as a component of Infliximab and can be employed for the quantitative analysis of this antibody. Infliximab is specifically designed to bind to TNF-α[1].
T38638	4-Trifluoromethylsalicylic acid-13C6 4-Trifluoromethylsalicylic acid-13C6,Desacetyl triflusal-13C6
	4-Trifluoromethylsalicylic acid-13C6 是 13C 标记的 4-Trifluoromethylsalicylic acid，主要用于药物开发过程中的定量示踪剂。4-Trifluoromethylsalicylic acid 也是一种血小板聚集抑制剂。
T39234	BODIPY-TS Thiol-green 2,BODIPY-TS
	BODIPY-TS (also known as Thiol-green 2) is a highly efficient thiol-specific turn-on probe with a fast response. It incorporates a thiosulfonate scaffold as its thiol recognition unit. BODIPY-TS displays excellent selectivity, low detection limit, and quantitative reactivity towards thiols. Moreover, it exhibits low toxicity. Notably, BODIPY-TS exhibits excitation at 490 nm and emission at 515 nm.
T76201	LEESGGGLVQPGGSMK TFA
	LEESGGGLVQPGGSMK TFA，作为一种蛋白水解肽，属于 Infliximab 成分，主要用于 Infliximab 的定量分析。Infliximab 为一种嵌合单克隆IgG1抗体，特异性结合 TNF-α。
T35514	2,6-Dibromoquinone-4-chloroimide
	2,6-Dibromoquinone-4-chloroimide is a colorimetric dye for the detection of phenolic compounds. It produces an indigo dye upon reacting with phenolic compounds at a pH of approximately 9.4. 2,6-Dibromoquinone-4-chloroimide has been used as a Gibbs reagent for the colorimetric detection of phenolic compounds. It has also been used in chromogenic reactions for the quantitative colorimetric detection of aflatoxins, causing colorless aflatoxins to become green with an absorption band at 673 nm.
T78453	Fast Blue B Salt
	Fast Blue B Salt作为染色剂，能溶解黑麦提取物中的脂肪及苯酚化合物和重氮剂。该化合物能够用于黑麦中的烷基间苯二酚半定量分析，并在加入丙酮的情况下形成有色沉淀。
T37333	(±)11(12)-DiHET MaxSpec® Standard
	(±)-11(12)-DiHET is an oxylipin. 11(S),12(S)-DiHET and 11(R),12(R)-DiHET are vicinal diols formedviaenzymatic hydration of 11(12)-EET by cytosolic or soluble epoxide hydrolases in a non-stereoselective manner.1,2,3(±)11(12)-DiHET MaxSpec standard is a quantitative grade standard of (±)11(12)-DiHET that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a de...
T36112	Clopidogrel Carboxylic Acid (hydrochloride)
	Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active thiol metabolite via CYP2C19 in the liver enables its anti-aggregating activity. An estimated 15% of administered clopidogrel is metabolized by CYP2C19 to the thiol metabolite. Clopidogrel carboxylic acid i...
T38128	Leukotriene D4 Leukotriene D4 MaxSpec® Standard,LTD4
	Leukotriene D4 (LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. It is the first cysteinyl-leukotriene metabolite of LTC4 . Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity. LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of...
T81199	SBP-1
	SBP-1是一种具有高选择性、灵敏性的亚硫酸盐生物发光探针（SBP），它通过亚硫酸盐介导的分子内裂解反应对亚硫酸盐进行识别。该探针可用于定量检测活体动物中外源性和内源性亚硫酸盐，以及溶液中一定浓度范围的亚硫酸盐。
TD0048	5-(and-6)-Carboxy SNARF-1, Acetoxymethyl Ester, Acetate
	The cell-permeant pH indicator, carboxy SNARF-1, acetoxymethyl ester, acetate (CAS #126208-13-7) has a pKa of ~7.5 after de-esterification, thus is useful for measuring pH changes between pH 7 and pH 8. Carboxy-SNARF-1 exhibits a significant pH-dependent
T37583	XTT (sodium salt hydrate)
	XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator.1,2It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.3 1.Berridge, M.V., Tan, A.S., and Herst, P.M.Tetrazolium dyes as tools in cell biology: New insights into their cellular reductionBiotechnol. Ann. Rev.11127-152(2005) 2.Berridge, M.V., and Tan, A.S.Trans-plas...
T37569	4-Methylumbelliferyl-β-D-Galactoside
	4-Methylumbelliferyl-β-D-galactoside (MUG) is a fluorogenic substrate for β-galactosidase (β-gal).1Hydrolysis of MUG by β-gal releases the fluorescent moiety 4-MU, which displays a pH-dependent excitation maximum of 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively, and an emission maximum between 445-454 nm.2MUG has been used to detect β-gal activity in intact bacteria, yeast, and mammalian cells.1 1.Vidal-Aroca, F., Giannattasio, M., Brunelli, E., et al.One-step high-throughput assay...
T36006	Olmesartan medoxomil impurity C
	Olmesartan medoxomil impurity C is an Olmesartan medoxomil impurity. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM. [1]. Senda A, et al. Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8. Biol Pharm Bull. 2015;38(12):1975-9. [2]. Shah S, et al. Simultaneous Quantitative Analysis of Olmesartan Medoxomil and Amlodipine Besylate in Plasma by High-performance Liquid Chromatography Technique. J Young Phar...

化合物

Itaconate-alkyne

Cat.No: T41302

Synonym: ITalk

Target: Others

5-Chlorovaleronitrile

Cat.No: T20456

Synonym: AI3 20151,5-氯戊腈,AI3-20151,AI320151

Target: Others

Cat.No: T16537

Target: Others

Cat.No: T15543

Synonym: N-Hex-5-ynyl-2-iodo-acetamide,Iodoacetamide-alkyne

Target: TRP/TRPV Channel

N-Formyl-Met-Leu-Phe-Lys

Cat.No: TP1168

Synonym: fMLFK

Target: Others

Pimonidazole hydrochloride

Cat.No: T16536

Cat.No: T66518

Synonym: BDP FL acid

Dansyl glutathione

Cat.No: T10956

Synonym: DNS-glutathione

Target: Others

19-hydroxy Cholesterol

Cat.No: T36217

Cat.No: T25902

Synonym: OVTA

Pirbuterol Acetate

Cat.No: T34079

Synonym: pirbuterol sulfate,EINECS 265-862-4,Maxair,Pirbuterol acetate (USAN)

Cat.No: T25773

Synonym: MalRP,Mal RP

Endotoxin Substrate

Cat.No: T82468

DSTYSLSSTLTLSK acetate

Cat.No: T39191L

Synonym: DSTYSLSSTLTLSK acetate (177792-42-6 Free base)

Target: Others

Cat.No: T39191

ROX Reference Dye

Cat.No: TD0086

LEESGGGLVQPGGSMK

Cat.No: T39521

Cat.No: T40674

Synonym: 碘克沙酸,P-286

DSTYSLSSTLTLSK TFA

Cat.No: T76209

LEESGGGLVQPGGSMK acetate

Cat.No: T36091

4-Trifluoromethylsalicylic acid-13C6

Cat.No: T38638

Synonym: 4-Trifluoromethylsalicylic acid-13C6,Desacetyl triflusal-13C6

Cat.No: T39234

Synonym: Thiol-green 2,BODIPY-TS

LEESGGGLVQPGGSMK TFA

Cat.No: T76201

2,6-Dibromoquinone-4-chloroimide

Cat.No: T35514

Fast Blue B Salt

Cat.No: T78453

(±)11(12)-DiHET MaxSpec® Standard

Cat.No: T37333

Clopidogrel Carboxylic Acid (hydrochloride)

Cat.No: T36112

Cat.No: T38128

Synonym: Leukotriene D4 MaxSpec® Standard,LTD4

Cat.No: T81199

5-(and-6)-Carboxy SNARF-1, Acetoxymethyl Ester, Acetate

Cat.No: TD0048

XTT (sodium salt hydrate)

Cat.No: T37583

4-Methylumbelliferyl-β-D-Galactoside

Cat.No: T37569

Olmesartan medoxomil impurity C

Cat.No: T36006

Cat. No.	Product Name	Target	Signaling Pathways
TN7030	Heteroclitin G	Others	Others
	Heteroclitin G 被发现是 KIS 补血活性的潜在生物标志物，定量分析为进一步药理研究提供了研究基础。
T5S0018	Betulonic acid 路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid	Parasite; HSV	Microbiology/Virology
	Betulonic acid (Liquidambaric acid) 是一种在许多植物中存在的三萜类天然产物，具有抗肿瘤，抗炎，抗寄生虫和抗病毒的活性。
T37770	Taurohyodeoxycholic acid
	Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid .1THDCA decreases the size and weight of human gallstonesin vitro. It increases bile flow, biliary cholesterol secretion, and biliary lipid secretion in rats.2Co-administration of THDCA with taurochenodeoxycholic acid prevents TCDCA-induced hepatotoxicity, increasing bile flow as well as biliary acid and phospholipid secretion in rats.3THDCA also reduces myeloperoxidase activity, expressi...

天然产物

Cat.No: TN7030

Target: Others

Cat.No: T5S0018

Synonym: 路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid

Target: Parasite, HSV

Taurohyodeoxycholic acid

Cat.No: T37770

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