Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6941 |
PI-1840
PI 1840 |
PARP; Proteasome | Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome; Ubiquitination |
PI-1840 是一种高效的、选择性的蛋白酶体chymotrypsin-like (CT-L)抑制剂,IC50=27nM。 | |||
T79742 |
CARM1 degrader-2
|
Histone Methyltransferase | Chromatin/Epigenetic |
CARM1 degrader-2 (compound 3e) 是一种效能高的CARM1降解剂,其DC50为8.8 nM。该化合物通过VHL途径及蛋白酶体作用实现CARM1的降解,进而抑制其底物PABP1和BAF155的甲基化作用,能够有效抑制乳腺癌细胞迁移。 | |||
T79741 |
CARM1 degrader-1
|
Histone Methyltransferase | Chromatin/Epigenetic |
CARM1 degrader-1 (compound 3b) 是一种针对co-activator associated argininemethyltransferase (CARM1) 的降解剂,其DC50为8.1 nM。它通过VHL和蛋白酶体依赖的途径降解CARM1,从而抑制了CARM1底物(例如PABP1和BAF155)的甲基化,进而抑制乳腺癌细胞的迁移。 |