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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8785 |
HALOFUGINONE LACTATE
|
DNA/RNA Synthesis; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Stem Cells |
HALOFUGINONE LACTATE 是 febrifugine 的卤化衍生物,它是一种天然的含有喹唑啉酮的化合物,存在于中草药 D. febrifuga 中。Halofuginone 以 ATP 依赖性方式抑制脯氨酰-tRNA 合成酶,Ki 为 18.3 nM。 Halofuginone 是 I 型胶原合成的特异性抑制剂,通过抑制 TGF-β 活性来减轻骨关节炎 (OA) | |||
T69800 | T-3861174 | ||
T-3861174 is a prolyl tRNA synthetase (PRS) inhibitor, exhibiting significant in vitro anti-tumor activity with GCN2-ATF4 pathway activation. | |||
T69741 |
DWN-12088 HCl
|
||
DWN-12088 HCl is the salt form of DWN-12088 Free Base, an orally administered small molecule prolyl-tRNA synthetase (PRS) inhibitor | |||
T39739 | Bersiporocin | ||
Bersiporocin, a prolyl-tRNA synthetase inhibitor, demonstrates potent activity with an IC50 of ≤100 nM against phosphoribosylpyrophosphate synthetase (PRS). This compound proves valuable for antifibrotic research. | |||
T72303 | Antibacterial agent 124 | ||
Antibacterial agent 124 是一种有效的细菌脯氨酸-tRNA 合成酶 (ProRS) 抑制剂,对 Staphylococcus aureusProRS (SaProRS) 的 IC50为 0.18 μM。 | |||
T79449 |
Antileishmanial agent-19
|
Parasite | Microbiology/Virology |
Antileishmanial agent-19 (Compound F27)是一种有效的抗利什曼病试剂,其对L. donovani promastigotes的IC50值为3.39 μM。该化合物能够抑制L. donovani promastigotes中的脯氨酰-tRNA合成酶,并干预宿主PI3K/Akt/CREB轴,从而抑制IL-10的分泌。此外,Antileishmanial agent-19能诱导L. donovani promastigotes自噬介导的细胞凋亡(apoptosis)过程,并在感染的动物体内显著减少寄生虫负担。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6856 |
Halofuginone
卤夫酮,常山酮,Tempostatin,empostatin,RU-19110 |
Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Stem Cells |
Halofuginone (RU-19110) 是Febrifugine 的衍生物,是一种竞争性脯氨酰-tRNA 合成酶抑制剂。它也是肺血管扩张剂,可激活Kv 通道并阻断电压门控、受体操作和存储操作的钙离子通道。它具有抗炎、抗癌、抗疟疾和抗纤维化作用。 | |||
T3524 |
Halofuginone hydrobromide
卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐 |
Others; Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Others; Stem Cells |
Halofuginone hydrobromid 是Febrifugine 的衍生物,是竞争性脯氨酰-tRNA 合成酶抑制剂。它是 I 型胶原合成的特异性抑制剂,并通过抑制TGF-β活性可减轻骨关节炎。它具有抗疟疾、抗炎、抗癌、抗纤维化作用。 |