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18

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T16745	Rhosin hydrochloride	Apoptosis; Rho; Ras	Apoptosis; Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	Rhosin hydrochloride 是一种特异性 RhoA 亚家族Rho GTPases 抑制剂，抑制 RhoA-GEF 相互作用。它通过增强 D1 中棘神经元的可塑性和降低过度兴奋性来促进应激恢复，可诱导细胞凋亡。
T8005	Cardiogenol C hydrochloride 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐,Cardiogenol C HCl,Cardiogenol C	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Cardiogenol C hydrochloride (Cardiogenol C) 是一种细胞渗透性嘧啶诱导剂，能够促使 ESCs 分化为心肌细胞。在有限的可塑性范围内，它可以对已经沿袭的祖细胞类型产生心肌生成效应，是一种心肌生成试剂，在动物模型中可以用作细胞移植研究中提高心脏修复的工具。
T2161	Cardiogenol C	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Cardiogenol C 是一种细胞渗透性嘧啶诱导剂，能够诱导 ESCs 分化为心肌细胞(EC50:100 nM)。在有限的可塑性范围内，它可以对已经沿袭的祖细胞类型产生心肌病，是一种心肌发生剂。
T7516	ZD7288 N-乙基-1,6-二氢-1,2-二甲基-6-(甲基亚氨基)-N-苯基-4-嘧啶胺盐酸盐,ICI D7288	HCN Channel	Membrane transporter/Ion channel
	ZD7288 (ICI D7288) 是一种选择性超极化激活的环核苷酸门控通道阻滞剂，可抑制海马突触可塑性。
T3597	Cutamesine dihydrochloride AGY94806 dihydrochloride,库他美新二盐酸盐,SA4503 (dihydrochloride),SA4503 dihydrochloride	Sigma receptor	GPCR/G Protein
	Cutamesine dihydrochloride (SA4503 dihydrochloride) 是一种选择性 σ1 受体激动剂，IC50值为 17.4 nM。
T70064	PDE1-IN-1
	PDE1-IN-1can enhance levels of the second messengers cAMP/cGMP leading to the expression of neuronal plasticity-related genes, neurotrophic factors, and neuroprotective molecules. These neuronal plasticity enhancement properties make PDE1 inhibitors good candidates as therapeutic agents in many neurological conditions.
T62055	NVS-BET-1
	NVS-BET-1 是 BET 溴结构域抑制剂。NVS-BET-1可以调节角质形成细胞可塑性。
T70032	NCI-006
	NCI-006 is a potent new inhibitor of lactate dehydrogenase (LDH) that disrupts tumor growth in mice. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both mitochondrial complex 1 and LDH suppresses metabolic plasticity of glycolytic tumors in vivo, significantly prolonging tumor growth inhibition.
T76078	Neurogranin (48-76), mouse
	Neurogranin (48-76)，mouse 为对应 Neurogranin 48-76 残基的多肽。该化合物是突触后表达的钙调素结合蛋白，通过调节 (Ca2+-CaM) 通路，介导 NMDAR 驱动的突触可塑性功能。
T62127	AMPA-IN-1
	AMPA-IN-1 是一种 AMPA 受体的有效抑制剂。AMPA 受体是一种在大脑中广泛表达的受体，在调节快速兴奋性突触传递和突触可塑性中具有核心作用。AMPA-IN-1 对包括癫痫在内的多种中枢疾病具有潜在的研究价值。
T37388	Afizagabar
	Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar enhances hippocampal synaptic plasticity and exhibits pro-cognitive efficacy[1]. Afizagabar (S44819) is a competitive α5-GABAAR antagonist (Kb=221 nM). Afizagabar selectively inhibits extrasynaptic α5-GABAARs of mouse CA1 pyramidal neurons[1]. Afizagabar (1 and 3 mg/kg; i.p.) significantly diminishes t...
T76221	Leptin (116-130)
	Leptin(116-130)是一种生物活性的瘦素片段，能促进AMPA受体运输至突触并加强活动依赖性的海马突触可塑性。此外，Leptin(116-130)在抗淀粉样蛋白毒性模型中有效阻止海马突触损伤和神经元细胞死亡，显示出对研究阿尔茨海默病(AD)具有重要潜力。
T82673	CPF-7 Caerulein precursor fragment
	CPF-7（Caerulein precursor fragment）是一种促进胰岛素释放的肽，可以通过增加PANC-1导管细胞中Snai1表达来引导上皮-间质转换（EMT），并且CPF-7还能通过提高Ngn3表达以诱导外分泌细胞可塑性。此外，CPF-7适用于2型糖尿病的相关研究。
TP2157L	TAT-DEF-Elk-1 TFA (1220751-16-5 free base) TDE TFA,TAT-DEF-Elk-1 TFA	Others	Others
	TAT-DEF-Elk-1 TFA is a cell-penetrating peptide Elk-1 inhibitor, mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation without interfering with ERK nor MSK1 act
T81038	TAT-DEF-Elk-1 TFA TDE TFA
	TAT-DEF-Elk-1 TFA (TDE TFA) 是一种Elk-1的细胞穿透性肽抑制剂，通过模仿Elk-1的DEF域并特异性地阻断其功能来抑制Elk-1。该化合物能够抑制Elk-1的磷酸化作用，阻止其核内转位，同时不影响ERK和MSK1的活化。TAT-DEF-Elk-1 TFA作为一种研究工具，对于探究神经元可塑性及Elk-1在该进程中的角色具有重要价值。
T38169	LY 341495 disodium salt
	Highly potent and selective group II metabotropic glutamate receptor antagonist. Disodium salt of LY 341495 Fitzjohn et al (1998) The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity. Neuropharmacology 37 1445 PMID:9886667 \|Ornstein et al (1998) 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl) glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects o...
T36679	Rp-cAMPS sodium salt
	Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6]. A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic t...
T37582	Ganglioside GM1 Mixture (ovine) (ammonium salt)
	Ganglioside GM1is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2It is found in a large variety of cells, including immune cells and neurons, and is enriched in lipid rafts in the cell membrane.3It associates with growth factor receptors, including TrkA, TrkB, and the GDNF receptor complex containing Ret and GFRα, and is required for TrkA expression on the cell surface. Ganglioside GM1interacts with other proteins to increase calcium i...

化合物

Rhosin hydrochloride

Cat.No: T16745

Target: Apoptosis, Rho, Ras

Cardiogenol C hydrochloride

Cat.No: T8005

Synonym: 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐,Cardiogenol C HCl,Cardiogenol C

Target: Wnt/beta-catenin

Cat.No: T2161

Target: Wnt/beta-catenin

Cat.No: T7516

Synonym: N-乙基-1,6-二氢-1,2-二甲基-6-(甲基亚氨基)-N-苯基-4-嘧啶胺盐酸盐,ICI D7288

Target: HCN Channel

Cutamesine dihydrochloride

Cat.No: T3597

Synonym: AGY94806 dihydrochloride,库他美新二盐酸盐,SA4503 (dihydrochloride),SA4503 dihydrochloride

Target: Sigma receptor

Cat.No: T70064

Cat.No: T62055

Cat.No: T70032

Neurogranin (48-76), mouse

Cat.No: T76078

Cat.No: T62127

Cat.No: T37388

Leptin (116-130)

Cat.No: T76221

Cat.No: T82673

Synonym: Caerulein precursor fragment

TAT-DEF-Elk-1 TFA (1220751-16-5 free base)

Cat.No: TP2157L

Synonym: TDE TFA,TAT-DEF-Elk-1 TFA

Target: Others

TAT-DEF-Elk-1 TFA

Cat.No: T81038

Synonym: TDE TFA

LY 341495 disodium salt

Cat.No: T38169

Rp-cAMPS sodium salt

Cat.No: T36679

Ganglioside GM1 Mixture (ovine) (ammonium salt)

Cat.No: T37582

Cat. No.	Product Name	Target	Signaling Pathways
T82339	Gangliotetraose Gg4
	Gangliotetraose（Gg4）是一种含有GM1及其唾液酸化衍生物的四糖。它能促进分化神经元核内Ca2+的外流，进而降低核内Ca2+浓度。Gg4参与调节神经元的可塑性、修复过程以及大脑中神经营养素的释放。

天然产物

Gangliotetraose

Cat.No: T82339

Synonym: Gg4

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