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Cat. No. | Product Name | Target | Signaling Pathways |
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T12146 |
N-Desmethyl-Apalutamide
N-Desmethyl Apalutamide,N-去甲基阿帕鲁胺杂质 |
P450; Androgen Receptor | Endocrinology/Hormones; Metabolism |
N-Desmethyl-Apalutamide 是一种 Apalutamide 的活性代谢产物,主要由 CYP2C8 和 CYP3A4 介导形成。它是一种低活性的雄激素受体拮抗剂,其作用力是 Apalutamide 活性的三分之一。它是中等至强的CYP3A4和CYP2B6诱导剂,并具有优异的血浆蛋白结合浓度。 | |||
T28248 |
Ono-3307 mesylate
Ono-3307,Ono3307,Ono 3307 |
Protease | Proteases/Proteasome |
Ono-3307 mesylate 是一种蛋白酶抑制剂,对多种蛋白酶均具有抑制作用。Ono-3307 mesylate 对大鼠的肝损伤具有显着的保护作用,抑制放射性纤维蛋白在肾脏和肺部的沉积 ,可用于研究胰腺炎。 | |||
T37020 |
Endosidin-2
ES2,Endosidin 2 |
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Endosidin-2是一种囊外囊抑制剂,具有细胞渗透性的亚苄基苯甲酰肼,可与外囊复合体70 kDa(EXO70)亚基的外囊成分结合(Kd = 253 μM,EXO70A1)。Endosidin-2会破坏蛋白质在内质体和质膜之间的转运,从而促进蛋白质转运至液泡降解。它还能抑制 HeLa 细胞中内吞转铁蛋白向质膜的再循环,并能靶向哺乳动物 EXO70的多种异构体,导致外泌失调。Endosidin2 可作为工具分子研究胞吐。 | |||
T31421 |
Diazodiiodoarsanilic acid
Dadiaa |
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Diazodiiodoarsenic acid was used to isolate plasma membrane proteins from platelets by means of affinity chromatography. | |||
T32184 |
Iothalamate meglumine
Cysto-Conray,Methylglucamine iotalamate,EINECS 235-998-9,Meglumine conray |
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Iothalamate meglumine, known as radiopaque medium, can be used for urography, angiography, venography, and myelography. It is highly viscous and can bind to plasma proteins. | |||
T38050 |
CP-609754
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Transferase | Metabolism |
CP-609754 是高效的、可逆的法尼基转移酶抑制剂,对重组人 H-Ras 和重组 K-Ras 法尼基化的 IC50分别为 0.57 ng/mL 和 46 ng/mL。CP-609754有潜在的抗癌作用。 | |||
TP1255 |
[Met5]-Enkephalin, amide
5-Methionine-enkephalin amide |
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[Met5]-Enkephalin, amide is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors.Met-enkephalin circulates in several forms, some of which may be derived from proteins other than proenkephalin A, and plasma levels of both free n | |||
T35790 |
Palmitic acid-1,2,3,4-13C4
Palmitic Acid-13C (C1, C2, C3, and C4 labeled) |
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Palmitic acid-13C (C1, C2, C3, and C4 labeled) is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively.1,2Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellula... | |||
T68334 | AF3442 | ||
AF3442 is a potent and selective mPGES-1 inhibitor (microsomal prostaglandin (PG) E synthase-1). AF3442 caused a concentration-dependent inhibition of PGE(2) in human recombinant mPGES-1 with an IC(50) of 0.06microM. AF3442 is a selective mPGES-1 inhibitor which reduced monocyte PGE(2) generation also in the presence of plasma proteins. Pharmacological inhibition of mPGES-1 did not translate into redirection of PGH(2) metabolism towards other terminal PG synthases in monocytes. The functional re... | |||
TP2254 |
GTP-Binding Protein Fragment, G alpha
|
Others | Others |
Using specific antisera raised against synthetic peptides, we find that three distinct GTP-binding protein alpha subunits remain bound to the plasma membrane even after activation with nonhydrolyzable GTP analog. Trypsin cleaves each alpha subunit at a si | |||
T35789 | Palmitic acid-1-13C | ||
Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6 |1. Santos, M.J., López-Jurado, M., Llopis, J., et a... | |||
T35791 | Palmitic acid-13C | ||
Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic ... | |||
T76663 |
pTH-Related Protein (1-40) (human, mouse, rat)
|
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pTH-Related Protein (1-40) (human, mouse, rat) 促进大鼠肠细胞通过PTHR1受体和PKCα/β信号通路的钙吸收作用。该蛋白增加了甲状旁腺激素1受体(PTHR1)表达,提升了四种跨膜钙转运蛋白—TRPV6、CaBP-D9k、NCX1和PMCA1的水平。 | |||
TP2176 |
amyloid A protein fragment [Homo sapiens]
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Others | Others |
Amyloid A proteins (H2N-Ala-Gly-Leu-Pro-Glu-Lys-Tyr-OH) are a family of apolipoproteins associated with high-density lipoprotein in plasma. Different isoforms of SAA are expressed constitutively at different levels or in response to inflammatory stimuli. | |||
T36701 | Phosphoramide mustard (cyclohexanamine) | ||
Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA damage and elicits the ovarian DNA repair response[1][2]. Phosphoramide mustard cyclohexanamine causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication[1].Phosphoramide mustard cyclohexanamine destroys rapidly dividing ce... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T5968 |
DL-Homocysteine thiolactone hydrochloride
DL-Homocysteinethiolactone hydrochloride,DL-高半胱氨酸硫内酯盐酸盐 |
Endogenous Metabolite | Metabolism |
DL-Homocysteine thiolactone hydrochloride (DL-Homocysteinethiolactone hydrochloride) 是具有根生长抑制特性的环状氨基酸衍生物。 | |||
T5280 |
3-Chloro-L-Tyrosine
3-氯-L-酪氨酸,3-Chlorotyrosine,Chlorotyrosine |
Others; Endogenous Metabolite | Metabolism; Others |
3-Chloro-L-Tyrosine (Chlorotyrosine) 是一种髓过氧化物酶催化氧化的特异性标志物,在从人动脉粥样硬化内膜分离的低密度脂蛋白中显著升高。 | |||
T5074 |
Cholesteryl palmitate
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Others; Endogenous Metabolite | Metabolism; Others |
Cholesteryl palmitate 是一种慢性间质性肺炎的有用预后生物标志物。 |