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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T9341	Bemnifosbuvir AT-511	Others; HCV Protease; SARS-CoV	Microbiology/Virology; Others; Proteases/Proteasome
	Bemnifosbuvir (AT-511) 是一种口服活性抑制剂，抑制 HCV 病毒复制，具有全基因型抗病毒活性。它有效抑制 SARS-CoV-2 (COVID-19)感染 (EC90=0.47 μM)。
T9331	Bemnifosbuvir hemisulfate AT-527	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Bemnifosbuvir hemisulfate (AT-527) 是一种 HCV 病毒复制抑制剂。
T17050	Tetraethyl butane-1,4-diylbis(phosphoramidate)	Others	Others
	Tetraethyl butane- 1, 4- diylbis(phosphoramid ate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
T39335	Anti-virus agent 1 Anti-virus agent 1,Remdesivir isopropyl ester analog
	Anti-virus agent 1 (compound 4i), a phosphoramidate prodrug of GS-5734, exhibits potent antiviral efficacy. It is primarily utilized in the study of coronavirus and Ebola virus (EBOV).
T78516	NUC-7738	Others	Others
	NUC-7738为3'-脱氧腺苷(3'-dA)的5'-芳氧基氨基磷酸酯前药，其对一组血液癌细胞系表现出有效细胞毒活性，可用于癌症研究。
T36881	NHC-diphosphate triammonium
	NHC-triphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form[1]. NHC-triphosphate triammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA[1][2]. In an intracellular metabolism assay, HCV replicon cells are treated with 10 μM 3H-labeled NHC, and intracellular nucleotide levels are determined after 1, 2 and 8 hours incubations. NHC is rapidly convered into the mono...
T36880	NHC-diphosphate
	NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a diphosphate form[1]. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV)[1]. Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC.Intracellular levels of the parental compounds and ...

化合物

Bemnifosbuvir

Cat.No: T9341

Synonym: AT-511

Target: Others, HCV Protease, SARS-CoV

Bemnifosbuvir hemisulfate

Cat.No: T9331

Synonym: AT-527

Target: HCV Protease, SARS-CoV

Tetraethyl butane-1,4-diylbis(phosphoramidate)

Synonym: Anti-virus agent 1,Remdesivir isopropyl ester analog

NHC-diphosphate triammonium

Cat. No.	Product Name	Target	Signaling Pathways
T38415	Adenosine 5′-monophosphoramidate sodium
	Adenosine 5′-monophosphoramidate sodium is a derivative of adenosine used as an intermediate for nucleotide synthesis. It significantly influences the accumulation of cyclic AMP.