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13

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6963	Reboxetine mesylate 瑞波西汀甲磺酸盐,FCE20124 mesylate,Edronax,PNU155950E mesylate,PNU 155950E,甲磺酸瑞波西汀	Adrenergic Receptor; Norepinephrine	GPCR/G Protein; Neuroscience
	Reboxetine mesylate (FCE20124 mesylate) 是一种高效、选择性的，特异性的去甲肾上腺素再摄取抑制剂(NARI)，能够抑制去甲肾上腺素再摄取(Ki=8 nM)，可用于抑郁症的研究。
T21013	Clomipramine Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina,氯米帕明	5-HT Receptor	GPCR/G Protein; Neuroscience
	Clomipramine (Clomicalm) 是一种三环类抗抑郁药，能够有效阻断 5-HT 再摄取 (IC50:1.5 nM) ，可用于研究强迫症 (OCD) 及抑郁症。
T22453	Venlafaxine Wy 45030,文拉法辛	Serotonin Transporter	Neuroscience
	Venlafaxine (Wy 45030) 是一种口服有效的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 重摄取的双重抑制剂，具有抗抑郁活性。
T4559	Isocarboxazid	Monoamine Oxidase	Neuroscience
	Isocarboxazid 是不可逆的、非选择性的单胺氧化酶 monoamine oxidase 抑制剂，其在大鼠大脑中测得的 IC50值为4.8 μM。
T3275	Nefazodone hydrochloride Dutonin,MJ-13754-1,Serzone,BMY-13754-1,BMY-13754,萘法唑酮盐酸盐	5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Nefazodone hydrochloride (Serzone) 是一种强效和选择性的5HT2A 拮抗剂，Ki 为5.8 nM，对 5-HT 和去甲肾上腺素摄取具有中度抑制作用，IC50分别为 290 和 300 nM。它是一种苯哌嗪类抗抑郁药，具有微弱的 α-肾上腺素阻断活性，用于治疗抑郁症、攻击性行为和恐慌症。
T16401	Org-12962	5-HT Receptor	GPCR/G Protein; Neuroscience
	Org-12962 是选择性，具有口服活性的 5-HT2C 受体激动剂，pEC50 值为 7.01。 Org-12962 对 5-HT2A 和 5-HT2B 受体也具有很高的作用，pEC50 分别为 6.38 和 6.28。Org-12962 在焦虑大鼠的模型中显示出缓解作用。
T71389	Fluoxetine oxalate
	Fluoxetine oxalate is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used for the treatment of major depressive disorder, obsessive–compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder.
T71587	Fluoxetine succinate ester
	Fluoxetine succinate ester is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used for the treatment of major depressive disorder, obsessive–compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder.
T26915	BTG-1640 ABIO-0801,ABIO-08-01,SP-1640
	BTG-1640 is used potentially for the treatment of anxiety and panic disorder.
T68683	Sertraline Free Base
	Sertraline Free Base is a Selective Serotonin Reuptake Inhibitor (SSRI). It can treat depression, obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), social anxiety disorder, and panic disorder.
T2579	Reboxetine 瑞波西汀,Norebox	Norepinephrine	Neuroscience
	Reboxetine (Norebox) 是一种抗抑郁药，用于治疗临床抑郁症、恐慌症和 ADD/ADHD。它有两个手性中心，但它仅作为两种对映体存在，(R, R)-(-)- 和 (S, S)-(+)-Reboxetine。
T79056	Orexin receptor modulator-1
	Orexin receptormodulator-1 是一款针对食欲素受体的调节剂，主要应用于物质成瘾、惊恐障碍、焦虑、创伤后应激障碍 (PTSD)、疼痛、抑郁、季节性情感障碍、进食障碍及高血压的科研领域。
T68579	Fluvoxamine acid
	Fluvoxamine acid is a medication which functions as a selective serotonin reuptake inhibitor (SSRI) and σ1 receptor agonist. Fluvoxamine is used primarily for the treatment of obsessive-compulsive disorder (OCD), and is also used to treat major depressive disorder (MDD), and anxiety disorders such as panic disorder and post-traumatic stress disorder (PTSD).

化合物

Reboxetine mesylate

Cat.No: T6963

Synonym: 瑞波西汀甲磺酸盐,FCE20124 mesylate,Edronax,PNU155950E mesylate,PNU 155950E,甲磺酸瑞波西汀

Target: Adrenergic Receptor, Norepinephrine

Cat.No: T21013

Synonym: Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina,氯米帕明

Target: 5-HT Receptor

Cat.No: T22453

Synonym: Wy 45030,文拉法辛

Target: Serotonin Transporter

Cat.No: T4559

Target: Monoamine Oxidase

Nefazodone hydrochloride

Cat.No: T3275

Synonym: Dutonin,MJ-13754-1,Serzone,BMY-13754-1,BMY-13754,萘法唑酮盐酸盐

Target: 5-HT Receptor, Adrenergic Receptor

Cat.No: T16401

Target: 5-HT Receptor

Fluoxetine oxalate

Cat.No: T71389

Fluoxetine succinate ester

Cat.No: T71587

Cat.No: T26915

Synonym: ABIO-0801,ABIO-08-01,SP-1640

Sertraline Free Base

Cat.No: T68683

Cat.No: T2579

Synonym: 瑞波西汀,Norebox

Target: Norepinephrine

Orexin receptor modulator-1

Cat.No: T79056

Fluvoxamine acid

Cat.No: T68579

Cat. No.	Product Name	Target	Signaling Pathways
TN2042	Paniculoside II	Others	Others
	Paniculoside II is a natural product from Stevia rebaudiana.
T83583	(±)-Paniculidine A
	(±)-Paniculidine A是Murraya paniculata植物中发现的一种天然化合物。
TN4735	Paniculidine A	Others	Others
	Paniculidine A is a natural product from Murraya exotica L.
TN4738	Paniculoside I FS-8855
	Paniculoside I(FS-8855) 是一种来自Pseudocaryopteris paniculata（CB Clarke）PD Cantino的酰化环烯醚醚萜葡萄糖苷。
TN4736	Paniculidine B	Others	Others
	Paniculidine B是一种天然产物，属于芸香科九里香属，其产品编号为 TN4736，CAS号为 97399-94-5。Paniculidine B可用作对照参考。
TN5600	Paniculoside III
	Paniculoside III is a natural product from the metabolites of the algicolous fungus Stevia paniculata.
TN4737	Paniculidine C	Others	Others
	Paniculidine C是一种天然产物，属于芸香科九里香属，其产品编号为 TN4737，CAS号为 97399-95-6。Paniculidine C可用作对照参考。
TN6832	Sulcatone 6-甲基-5-庚烯-2-酮,6-methylhept-5-en-2-one,6-Methyl-5-hepten-2-one	Endogenous Metabolite	Metabolism
	Sulcatone (6-Methyl-5-hepten-2-one) 是内源性代谢产物的一种。

天然产物

Paniculoside II

Cat.No: TN2042

Target: Others

(±)-Paniculidine A

Cat.No: T83583

Paniculidine A

Cat.No: TN4735

Target: Others

Paniculoside I

Cat.No: TN4738

Synonym: FS-8855

Paniculidine B

Cat.No: TN4736

Target: Others

Paniculoside III

Cat.No: TN5600

Paniculidine C

Cat.No: TN4737

Target: Others

Cat.No: TN6832

Synonym: 6-甲基-5-庚烯-2-酮,6-methylhept-5-en-2-one,6-Methyl-5-hepten-2-one

Target: Endogenous Metabolite

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