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Cat. No.	Product Name	Target	Signaling Pathways
T4215	TCS-PIM-1-4a 5-[[3-(三氟甲基)苯基]亚甲基]-2,4-噻唑烷二酮,SMI-4a	Apoptosis; Pim	Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling
	TCS-PIM-1-4a (SMI-4a) 是一种泛-Pim 激酶抑制剂，可通过激活 AMPK 来阻断 mTORC1的活性。它可杀死多种髓样和淋巴样细胞系，IC50值为 0.8 μM 至 40 μM。
T9229	Pim-1/2 kinase inhibitor 1	Pim	Chromatin/Epigenetic; JAK/STAT signaling
	Pim-1/2 kinase inhibitor 1 是一种具有口服活性的 Pim-1/2 激酶抑制剂。Pim-1/2 kinase inhibitor 1 能阻断 Pim 激酶磷酸化肽的能力，并且抑制4E-BP1和p27Kip1的Pim 蛋白激酶定向磷酸化。Pim-1/2 kinase inhibitor 1 可用于癌症，尤其是前列腺癌的研究。
T14896	CC0651	Others	Others
	CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. CC0651 potently inhibits the ubiquitination of p27Kip1 (IC50: 1.72 μM).
T25889	NSC-689857 NSC 689857,NSC689857
	NSC-689857 is an inhibitor that acts in the Skp2-Cks1 protein-protein interaction and p27Kip1 ubiquitination in vitro.
TP2128	R8-T198wt
	Cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. Inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. Also inhibits Pim-1-dependent growth of DU145 cells
T30795	CEP-1612 CEP 1612,UNII-9K6U075027
	CEP-1612 is a proteasomal inhibitor responsible for the proteolysis of proteins that regulate important cell cycles and apoptosis. CEP-1612 can induce p21WAF1 and p27KIP1 expression and apoptosis, and inhibit tumor growth of human lung cancer.
T35536	Tpl2 Kinase Inhibitor (hydrochloride)
	Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC50= 0.05 μM).1It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 μM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-α production in isolated human monocytes and whole blood (IC50s = 0.7 and 8.5 μM, respectively). It enhances differentiation induced by calcitriol in HL-60 and U937 leukemia cells when used at a concentration of 5 μM.2Tpl2 kinase inhibitor (5...

化合物

Cat.No: T4215

Synonym: 5-[[3-(三氟甲基)苯基]亚甲基]-2,4-噻唑烷二酮,SMI-4a

Target: Apoptosis, Pim

Pim-1/2 kinase inhibitor 1

Cat.No: T9229

Target: Pim

Cat.No: T14896

Target: Others

Cat.No: T25889

Synonym: NSC 689857,NSC689857

Cat.No: TP2128

Cat.No: T30795

Synonym: CEP 1612,UNII-9K6U075027

Tpl2 Kinase Inhibitor (hydrochloride)

Cat.No: T35536

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