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Search Results for " p20 "

Targets Recommended: Others

抑制剂 & 化合物

天然产物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T14299	AP20187 B/B Homodimerizer	Others	Others
	AP20187 (B/B Homodimerizer) 是一种细胞渗透性配体，用于二聚化 FK506 结合蛋白 (FKBP) 融合蛋白。它启动生物信号级联和基因表达或破坏蛋白质-蛋白质相互作用。
T34688	SP203 SP-203,SP 203
	SP203 is a radioligand for brain metabotropic glutamate receptor imaging.
T13256	UP202-56	AChR	Neuroscience
	UP202-56 is an adenosinergic agonist and is an adenosine analog.
T77579	JC2-11	IL Receptor; Dehydrogenase; ROS; Caspase; NOD-like Receptor (NLR); AIM2	Apoptosis; Immunology/Inflammation; Metabolism; Proteases/Proteasome
	JC2-11 是一种对炎症有抑制作用的化合物。JC2-11 对含有募集结构域的蛋白质 NLRC 4、黑色素瘤 2 中缺失 (AIM 2) 和非典型 (NC) 炎症小体有抑制作用，通过破坏活性氧的产生和 caspase-1 的活性来抑制炎症小体的活化。JC2-11 减少了炎症小体中 caspase-1 (p20) 的分泌、gasdermin D (GSDMD) 的裂解、IL-1β 和乳酸脱氢酶 (LDH) 的释放。
T62501	PD-1/PD-L1-IN-17
	PD-1/PD-L1-IN-17 (Compound P20) 是一种有效的 PD-1/PD-L1 抑制剂 (IC50: 26.8 nM)。PD-1/PD-L1-IN-17 是一种很有前途的先导化合物，能够用于 PD-1/PD-L1 相互作用抑制剂的开发。PD-1/PD-L1-IN-17 具有潜力进行癌症疾病的研究。
T82189	HMGB1-IN-2
	HMGB1-IN-2 (compound 15) 是一种针对高度保守的核蛋白 HMGB1 的抑制剂，其在 RAW264.7 细胞中展现出 NO 抑制活性，IC50 为 20.2 μM。 HMGB1-IN-2 (30 μM) 能够减少 IL-1β、TNF-α、caspase-1 p20 的表达，并抑制 NF-κB p65 的磷酸化作用，显示出抗凋亡特性。在脓毒症急性肾损伤模型的小鼠中，HMGB1-IN-2（15 mg/kg；腹腔注射）可有效减轻肾脏伤害。此外，HMGB1-IN-2 对 Huh7 细胞和 A549 细胞的 IC50 分别为 77.0 μM 和 82.0 μM。

化合物

AP20187

Cat.No: T14299

Synonym: B/B Homodimerizer

Target: Others

SP203

Cat.No: T34688

Synonym: SP-203,SP 203

Target: IL Receptor, Dehydrogenase, ROS, Caspase, NOD-like Receptor (NLR), AIM2

Cat. No.	Product Name	Target	Signaling Pathways
T79992	Sarglaroids F	Caspase	Apoptosis; Proteases/Proteasome
	Sarglaroids F（化合物6）为从草珊瑚根部提取的抗炎剂，影响K+外排并降低Caspase-1(P20)水平以抑制LPS/ATP诱导的IL-1β释放，对RAW264.7细胞无细胞毒性。

天然产物

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Cat. No.	Product Name	Species	Expression System
TMPY-03397	TPPP3 Protein, Human, Recombinant (His) CGI-38,TPPP3,p25gamma,tubulin polymerization-promoting prote...	Human	E. coli
	TPPP3, a member of the Tubulin polymerization-promoting protein family, is an intrinsically unstructured protein that induces tubulin polymerization. TPPP3 is a marker in the developing musculoskeletal system. In tendons, Tppp3 is expressed in cells at the circumference of the developing tendons, likely the progenitors of connective tissues that surround tendons: the tendon sheath, epitenon, and paratenon. Tppp3 is also expressed in forming synovial joints. The onset of Tppp3 expression in joint...
TMPH-03033	P200 Protein, Mycoplasma pneumoniae, Recombinant (His & Myc)	Mycoplasma pneumoniae	E. coli
	Protein cytoskeleton-associated which plays a role in gliding motility and perhaps also in mucociliary clearance.