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22

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2158	Nutlin-3 Nutlin3	E1/E2/E3 Enzyme	Ubiquitination
	Nutlin-3 是一种 MDM2 拮抗剂，抑制 MDM2-p53 相互作用，Ki 为 90 nM，并激活 p53。
T6254	Idasanutlin RG7388,Ro 5503781,依达奴林	Mdm2; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	Idasanutlin (Ro 5503781) 是一种有效且特异性的 p53-MDM2 抑制剂，IC50值为 6 nM。
T6614	Nutlin-3b (+)-Nutlin-3,4-[[(4R,5S)-4,5-双(4-氯苯基)-4,5-二氢-2-[4-甲氧基-2-(1-甲基乙氧基)苯基]-1H-咪唑-1-基]羰基]-2-哌嗪酮	Mdm2; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	Nutlin-3b ((+)-Nutlin-3) 是一种 p53/MDM2 拮抗剂或抑制剂，IC50为 13.6 μM。它与 MDM2 的结合活性比 Nutlin-3a 低 150 倍。
T9924	Obinutuzumab 奥滨尤妥珠单抗,Obinutuzumab/afutuzumab	Others	Others
	Obinutuzumab (Obinutuzumab/afutuzumab)/afutuzumab 是一种新型糖工程化 II 型 CD20单克隆抗体，用于研究非霍奇金淋巴瘤。
T6023	Nutlin-3a (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3	Apoptosis; E1/E2/E3 Enzyme; Autophagy	Apoptosis; Autophagy; Ubiquitination
	Nutlin-3a ((−)-Nutlin-3) 是 Nutlin-3 的活性对映体，是一种 MDM2抑制剂，可抑制 MDM2-p53相互作用，稳定 p53 蛋白，从而诱导细胞自噬和凋亡，有潜力研究 TP53野生型卵巢癌。
T69115	Nutlin-1
	Nutlin-1 is a p53-MDM2 binding inhibitor, p-Glycoprotein (p-gp) transport substrate, and antitumor agent.
T124114	Microminutin
	Microminutin 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T124114，CAS号为 84041-46-3。
T17902	Nutlin-C1-amido-PEG4-C2-N3 E3 ligase Ligand-Linker Conjugates 48,MDM2 Ligand-Linker Conjugates 1	Others	Others
	Nutlin-C1-amido-PEG4-C2-N3 is a novel compound that functions as a ligand-linker conjugate for the E3 ligase. It is a synthesized molecule incorporating the MDM2 ligand derived from Nutlin 3, and a 4-unit PEG linker. This compound is specifically designed for utilization in PROTAC technology.
T17874	Nutlin carboxylic acid MDM2 ligand 1,E3 ligase Ligand 16	Others	Others
	Nutlin Carboxylic Acid (MDM2 ligand 1), derived from Nutlin 3, serves as an MDM2 ligand. It can be attached to a protein ligand via a linker to create PROTACs[1].
T69114	Nutlin-2
	Nutlin-2 is a potent and selective p53-MDM2 binding inhibitor.
T6613	(Rac)-Nutlin-3

T17873	(4R,5S)-nutlin carboxylic acid E3 ligase Ligand 15,MDM2 ligand 2	Others	Others
	(4R,5S)-Nutlin Carboxylic Acid (MDM2 Ligand 2), a Nutlin 3-based MDM2 ligand, can be conjugated to a protein-binding ligand via a linker to create PROTACs[1].
T36358	Diminutol
	Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 μM), to destabilize microtubules and disrupt mitosis. At 50 μM, it directly affects tubulin polymerization in Xenopus egg extracts without interfering with the activity of Cdk1, DNA replication, or actin polymerization.
T126508	Cornutaside C
	Cornutaside C 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126508，CAS号为 102848-64-6。
T75589	Bitis Cornuta Venom
	Bitis Cornuta Venom (Many-horned Adder Venom) 是从 Bitis Cornuta 提取的蛇毒，含有sPLA2毒素，该毒素具有通过抑制凝血酶原复合物以发挥抗凝活性的能力，并能促使凝血酶原转化为凝血酶，引发凝块形成。
T80878	Vanutide cridificar PF 05236806,ACC-001
	Vanutide cridificar (ACC-001)是一种氨基末端Aβ1-7肽的偶联物，用于阿尔茨海默病(AD)的研究。
T37555	Cardanol triene
	Cardanol triene is a phenol found in cashew nut shell liquid that reversibly inhibits tyrosinase with an IC50 value of 40.5 μM in vitro. A mixture of cardanol mono-, di-, and triene is used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation.
T35759	Cardol triene
	Cardol triene is a phenol found in cashew nut shell liquid that competitively and irreversibly inhibits mushroom tyrosinase (IC50 = 22.5 μM). It is schistosomicidal, killing 25, 75, and 100% of S. mansoni worms after 24 hours when used at concentrations of 50, 100, or 200 μM, respectively. It has been used as a starting material for the synthesis of bis-benzoxazines.
T71813	Cardanol diene
	Cardanol diene is a phenol found in cashew nut shell liquid that inhibits tyrosinase with an IC50 value of 52.5 μM in vitro. Cardanol diene is also used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation.
T70593	GW-841819X
	GW841819X is an analogue of (+)-JQ1 and a novel inhibitor of BET bromodomains. GW841819X displayed activity in vivo against NUT-midline carcinoma, multiple myeloma, mixed-lineage leukemia, and acute myeloid leukemia. Bromodomain and extra-terminal (BET) proteins belong to a class of proteins collectively called epigenetic readers". BET bromodomains have emerged as promising drug targets for treatment of cancers
T35487	Anacardic Acid Diene
	Anacardic acid diene is a polyunsaturated form of anacardic acid that has been found in cashew nut shell liquid. It has antibacterial activity against methicillin resistant S. aureus (MRSA) and S. mutans (MICs = 12.5 and 6.25 μg/ml, respectively). Anacardic acid diene has schistosomicidal activity against adult S. mansoni worms when used at a concentration of 100 μM. It also inhibits soybean lipoxygenase-1 in a time-dependent manner.
T36574	GW841819X GW841819X
	GW841819X is an analogue of (+)-JQ1 and a novel inhibitor of BET bromodomains. GW841819X was a single enantiomer but of undefined chirality at the 4-position of the benzodiazepine ring3. GW841819X and JQ1 were recently discovered that bind to the acetyl-lysine binding pocket of BET bromodomains with Kd ranges from 50 to 370 nM [1]. GW841819X bounded to both the individual BD1 and BD2 domains with affinities of 46 and 52.5 nM, respectively. GW841819X-Brd3 interaction was estimated to be around 70...

化合物

Cat.No: T2158

Synonym: Nutlin3

Target: E1/E2/E3 Enzyme

Cat.No: T6254

Synonym: RG7388,Ro 5503781,依达奴林

Target: Mdm2, E1/E2/E3 Enzyme

Cat.No: T6614

Synonym: (+)-Nutlin-3,4-[[(4R,5S)-4,5-双(4-氯苯基)-4,5-二氢-2-[4-甲氧基-2-(1-甲基乙氧基)苯基]-1H-咪唑-1-基]羰基]-2-哌嗪酮

Target: Mdm2, E1/E2/E3 Enzyme

Cat.No: T9924

Synonym: 奥滨尤妥珠单抗,Obinutuzumab/afutuzumab

Target: Others

Cat.No: T6023

Synonym: (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3

Target: Apoptosis, E1/E2/E3 Enzyme, Autophagy

Cat.No: T69115

Cat.No: T124114

Nutlin-C1-amido-PEG4-C2-N3

Cat.No: T17902

Synonym: E3 ligase Ligand-Linker Conjugates 48,MDM2 Ligand-Linker Conjugates 1

Target: Others

Nutlin carboxylic acid

Cat.No: T17874

Synonym: MDM2 ligand 1,E3 ligase Ligand 16

Target: Others

Cat.No: T69114

(Rac)-Nutlin-3

Cat.No: T6613

(4R,5S)-nutlin carboxylic acid

Cat.No: T17873

Synonym: E3 ligase Ligand 15,MDM2 ligand 2

Target: Others

Cat.No: T36358

Cat.No: T126508

Bitis Cornuta Venom

Cat.No: T75589

Vanutide cridificar

Cat.No: T80878

Synonym: PF 05236806,ACC-001

Cardanol triene

Cat.No: T37555

Cat.No: T35759

Cat.No: T71813

Cat.No: T70593

Anacardic Acid Diene

Cat.No: T35487

Cat.No: T36574

Synonym: GW841819X

Cat. No.	Product Name	Target	Signaling Pathways
TJS0123	Guvacine ethyl ester 槟榔碱,PT00442-2	Others	Others
	Guvacine ethyl ester (Arecoline) 是一种生物碱，存在于槟榔中，可用于 GABA 摄取抑制剂的合成。
TN3594	Cardanol (C15:1)	Apoptosis; Others	Apoptosis; Others
	Cardanol (C15:1) 存在于腰果壳液中，可诱导人黑色素瘤细胞线粒体相关的细胞凋亡。
T68953	Arecoline	Reactive Oxygen Species; AChR	Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	Arecoline 是一种来自棕榈科植物槟榔的天然生物碱，是有效的烟碱和毒蕈碱乙酰胆碱受体的部分激动剂。Arecoline 具有抗焦虑和抗寄生虫活性，可诱导氧化应激，可用于研究阿尔茨海默病和老年性痴呆。
T80014	Guvacine hydrobromide	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Guvacine hydrobromide为槟榔中提取的生物碱，具有作为GABA摄取抑制剂的活性。该化合物对大鼠GAT-1、GAT-2和GAT-3的GABA摄取抑制作用具有不同的IC50值，分别为39 μM、58 μM及378 μM。

天然产物

Guvacine ethyl ester

Cat.No: TJS0123

Synonym: 槟榔碱,PT00442-2

Target: Others

Cardanol (C15:1)

Cat.No: TN3594

Target: Apoptosis, Others

Cat.No: T68953

Target: Reactive Oxygen Species, AChR

Guvacine hydrobromide

Cat.No: T80014

Target: GABA Receptor

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