Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4246 |
Varenicline dihydrochloride
|
AChR | Neuroscience |
Varenicline dihydrochloride是一种选择性 α4β2 烟碱乙酰胆碱受体部分激动剂。 | |||
T10432L |
AZD-8529 mesylate
|
GluR | Neuroscience |
AZD-8529 mesylate 是高度选择性的可口服mGluR2正向调节剂,EC50值为 285 nM。它在 20-25 M 时,对 mGluR1、3、4、5、6、7 和 8 亚型没有显示正变构调节剂反应。 | |||
T61562 |
CB1R Allosteric modulator 3
|
cAMP; Cannabinoid Receptor | GPCR/G Protein |
CB1R Allosteric modulator 3 是一种有效的 CB1R 调制剂。CB1R Allosteric modulator 3 抑制 cAMP 和 β-Arrestin ,可用于研究肥胖和尼古丁成瘾。 | |||
T37094 |
(S)-UFR2709 hydrochloride
(S)-UFR2709 hydrochloride |
||
(S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S)-UFR2709 (hydrochloride) decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 (hydrochloride) acts as an anxiolytic agent and can be used for the study of nicotine addiction[1][2]. Brain nicotinic acetylcholine receptors (nAChRs) is a heterogeneous family of pentameric acetylcholine-gated cation channels, whi... | |||
T16563 |
Pozanicline
ABT-089 |
AChR | Neuroscience |
Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction. Pozanicline selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a no | |||
T38903 |
(S)-UFR2709
(S)-UFR2709 |
||
(S)-UFR2709 is a competitive antagonist of the nicotinic acetylcholine receptor (nAChR), exhibiting a greater affinity for α4β2 nAChRs compared to α7 nAChRs. It effectively reduces anxiety and ethanol consumption, as well as ethanol preference, in alcohol-preferring rats. Additionally, (S)-UFR2709 functions as an anxiolytic agent and holds the potential for investigating nicotine addiction. |