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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T21505	Suberoyl bis-hydroxamic acid SBHA,软木肟酸,Suberohydroxamic acid	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Suberoyl bis-hydroxamic acid (SBHA) 是一种竞争性且可透过细胞的HDAC1和HDAC3抑制剂，ID50值分别为 0.25 μM 和 0.30 μM。它使肿瘤细胞易于凋亡并促进线粒体凋亡途径，可研究甲状腺髓样癌。
T0134	Imiquimod 咪喹莫特,R 837,S-26308	SARS-CoV; TLR; Autophagy; HSV	Autophagy; Immunology/Inflammation; Microbiology/Virology
	Imiquimod (R 837) 是一种免疫反应修饰剂，可作为 toll 样受体7 激动剂。它有抗病毒和抗肿瘤作用，可研究外生殖器、肛周疣、癌症和 COVID-19。
T35182	Xinidamine BRN 0891979,Xinidaminum,Xinidamino
	Xinidamine (BRN 0891979) 具有抗肿瘤活性，可用于研究良性前列腺增生、黄斑变性和前列腺上皮内瘤。Xinidamine 对PWR-1E 细胞的增殖具有抑制作用，IC50为4μM。
T67786	ABI-1968 PM
	ABI-1968 PM 是ABI-1968的一种衍生物。ABI-1968是一种细胞凋亡刺激剂，是一种病毒复制抑制剂。ABI-1968可用于研究宫颈上皮内瘤样病变、乳头状瘤病毒感染和鳞状上皮内病变。
T68306	INCB16562
	INCB16562 is a novel, selective, and orally bioavailable small-molecule inhibitor of JAK1 and JAK2 markedly selective over JAK3. Treatment of myeloma cells with INCB16562 potently inhibited interleukin-6 (IL-6)-induced phosphorylation of STAT3. INCB16562 abrogated the protective effects of recombinant cytokines or bone marrow stromal cells and sensitized myeloma cells to cell death by exposure to dexamethasone, melphalan, or bortezomib. Oral administration of INCB16562 antagonized the growth of ...

化合物

Suberoyl bis-hydroxamic acid

Cat.No: T21505

Synonym: SBHA,软木肟酸,Suberohydroxamic acid

Target: Apoptosis, HDAC

Imiquimod

Cat.No: T0134

Synonym: 咪喹莫特,R 837,S-26308

Target: SARS-CoV, TLR, Autophagy, HSV

Xinidamine

Cat.No: T35182

Synonym: BRN 0891979,Xinidaminum,Xinidamino

Cat. No.	Product Name	Target	Signaling Pathways
T1033L	Monensin Elancoban,Rumensin,莫能菌素
	Monensin is an antiprotozoal agent produced by Streptomyces cinnamonensis. It has an inhibitory effect on the Wnt/β-catenin signaling cascade. Monensin is a prospective anticancer drug for the therapy of neoplasia with deregulated Wnt signaling.