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Search Results for " mutase "

13

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T78346	Superoxide dismutase SOD
	超氧化物歧化酶(SOD)是能清除超氧阴离子的抗氧化酶，它将自由基转化为氧气和过氧化氢，防止过氧亚硝酸盐的形成和进一步损伤。该酶在抗炎、抗肿瘤、辐射防护及抗衰老领域有着广泛应用和研究。
T76121	Phosphoglucomutase	Endogenous Metabolite	Metabolism
	Phosphoglucomutase可促进弓形虫的囊肿发育。缺乏 Phosphoglucomutase 会引发代谢疾病。
T2346L	Enasidenib mesylate AG221 mesylate,AG 221 mesylate,恩西地平甲磺酸盐,AG-221 mesylate	Dehydrogenase	Metabolism
	Enasidenib mesylate (AG-221 mesylate) 是一种具有有效性和选择性的 IDH2 突变酶抑制剂，可促进白血病成髓细胞的分化，可用于治疗急性髓系白血病。
T29296	1-Deaza-fad Deazafad,5-Deazariboflavin-5'-diphosphate,1-deazaFAD
	1-Deaza-fad also known as Deazafad. 1-deazaFAD has comparable activity in the mutase reconstituted.
T1182L	Levocarnitine propionate L-Propionylcarnitine,ST261,ST 261,Propionyl-L-carnitine,ST-261
	Propionylcarnitine is present in high abundance in the urine of patients with Methylmalonyl-CoA mutase (MUT) deficiency.
T28049	MJE3 MJE 3,MJE-3
	MJE3 is an inhibitor of phosphoglycerate mutase-1 (PGAM1), it displays antiproliferative effects in human breast cancer cells by inhibiting glycolysis.
T12440	PGAM1-IN-2	Others	Others
	PGAM1-IN-2 是一种有效的磷酸甘油酸变位酶 1 (PGAM1) 抑制剂 (IC50=2.1 μM)。
T16517	PGMI-004A	Phosphatase	Metabolism
	PGMI-004A 是磷酸甘油酸变位酶 1 抑制剂，IC50=13.1 μM。
T12439	PGAM1-IN-1	Others	Others
	PGAM1-IN-1 是一种有效的磷酸甘油酸变位酶 1 (PGAM1) 抑制剂(IC50=6.4 μM)。
T61998	UGM-IN-3
	UGM-IN-3 (compound 10a) 是一种 UDP-吡喃半乳糖变位酶 (UGM) 抑制剂，Kd 为 66 μM。UGM-IN-3 抑制结核分枝杆菌的生长，MIC 值为 6.2 μg/mL。
T37116	Ethylmalonyl Coenzyme A (sodium salt)
	Ethylmalonyl coenzyme A (CoA) is a key intermediate in the ethylmalonyl-CoA pathway for carbon metabolism in certain bacteria, such asM. extorquens, which uses this pathway when grown on ethylamine.1,2It is produced from crotonyl-CoA by crotonyl-CoA reductase/carboxylase and modified by ethylmalonyl-CoA mutase to make methylsuccinyl-CoA. 1.Good, N.M., Martinez-Gomez, N.C., Beck, D.A.C., et al.Ethylmalonyl coenzyme A mutase operates as a metabolic control point in Methylobacterium extorquens AM1J...
T37249	Methylmalonyl-Coenzyme A (sodium salt)
	Methylmalonyl coenzyme A (methylmalonyl-CoA) is an intermediate in multiple metabolic pathways in bacteria and eukaryotes.1,2,3It is an intermediate in carbon assimilation in certain bacteria and carbon fixation in plants.1,2Methylmalonyl-CoA is converted to succinyl-CoA by methylmalonyl-CoA mutase with vitamin B12as a coenzyme.3A deficiency in vitamin B12leads to a build-up of methylmalonyl-CoA.4 1.Anthony, C.How half a century of research was required to understand bacterial growth on C1 and C...
T22343	HKB99	Others	Others
	HKB99 是磷酸甘油酸突变酶 1 (PGAM1) 的突变抑制剂。HKB99可增加氧化应激，激活JNK/c-Jun，抑制AKT和ERK[1]。HKB99可抑制侵袭性假栓的形成，提高PAI-2的水平，可用于非小细胞肺癌（NSCLC）的研究[2]。

化合物

Superoxide dismutase

Cat.No: T78346

Synonym: SOD

Phosphoglucomutase

Cat.No: T76121

Target: Endogenous Metabolite

Enasidenib mesylate

Cat.No: T2346L

Synonym: AG221 mesylate,AG 221 mesylate,恩西地平甲磺酸盐,AG-221 mesylate

Target: Dehydrogenase

Cat.No: T29296

Synonym: Deazafad,5-Deazariboflavin-5'-diphosphate,1-deazaFAD

Levocarnitine propionate

Cat.No: T1182L

Synonym: L-Propionylcarnitine,ST261,ST 261,Propionyl-L-carnitine,ST-261

Cat.No: T28049

Synonym: MJE 3,MJE-3

Cat.No: T12440

Target: Others

Cat.No: T16517

Target: Phosphatase

Cat.No: T12439

Target: Others

Cat.No: T61998

Ethylmalonyl Coenzyme A (sodium salt)

Cat.No: T37116

Methylmalonyl-Coenzyme A (sodium salt)

Cat.No: T37249

Cat.No: T22343

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3377	L-Phenylalanine L-苯丙氨酸,(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine	Calcium Channel; Endogenous Metabolite; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	L-Phenylalanine (3-Phenyl-L-alanine) 是分离自大肠杆菌的必需氨基酸，是 NMDARs(KB573 μM) 和非 NMDARs 的甘氨酸和谷氨酸结合位点的竞争性拮抗剂，用于食品香料和药品的生产中。它是一种电压依赖性 α2δ 亚基 Ca2+通道拮抗剂，Ki 为 980 nM。
T14128	Adenosylcobalamin Cobamamide,Coenzyme B12,腺苷钴胺,AdoCbl	Endogenous Metabolite	Metabolism
	Adenosylcobalamin (AdoCbl) 是一种 Vitamin B12的特性形式，其中 Vitamin B12 是是甲基丙二酰 CoA 突变酶的辅助因子。

天然产物

L-Phenylalanine

Cat.No: T3377

Synonym: L-苯丙氨酸,(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine

Target: Calcium Channel, Endogenous Metabolite, iGluR

Adenosylcobalamin

Cat.No: T14128

Synonym: Cobamamide,Coenzyme B12,腺苷钴胺,AdoCbl

Target: Endogenous Metabolite

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