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Cat. No. | Product Name | Target | Signaling Pathways |
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T37657 | Mitochondrial respiration-IN-1 hydrobromide | ||
Mitochondrial respiration-IN-1 hydrobromide (compound 49) is a potent mitochondrial inhibitor (IC50=8.8 mg/mL). Mitochondrial respiration-IN-1 hydrobromide significantly reduces mitochondrial respiration in platelets[1]. | |||
T72137 |
Mitochondrial respiration-IN-3
|
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Mitochondrial respiration-IN-3 是 Dalfopristin 的氟衍生物。Mitochondrial respiration-IN-3 具有细胞膜渗透性。Mitochondrial respiration-IN-3 可以抑制胶质母细胞瘤干细胞的线粒体翻译 (mitochondrial translation)。Mitochondrial respiration-IN-3 可用于癌症的研究 | |||
T72138 | Mitochondrial respiration-IN-2 | ||
Mitochondrial respiration-IN-2 是Virginiamycin M1 的氟衍生物。Mitochondrial respiration-IN-2 可以抑制胶质母细胞瘤干细胞的线粒体翻译。 | |||
T9235 |
GW604714X
2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- |
Mitochondrial Metabolism | Metabolism |
GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) 是一种高度特异性的线粒体丙酮酸载体抑制剂,Ki<0.1 nM。它是一种线粒体呼吸抑制剂。它也能抑制质膜单羧酸转运体的 L-乳酸转运,但浓度比 MPC 的大 4 个数量级。 | |||
T21275 |
Azoxystrobin
HSDB 7017,ICI-A 5504,Bankit,ICIA-5504,Amistar |
Antifungal | Microbiology/Virology |
Azoxystrobin (Bankit) 是一种广谱杀菌剂。 Azoxystrobin 通过阻断细胞色素 b 和 c1 之间的电子转移来诱导 ROS 产生、细胞凋亡和线粒体呼吸。 | |||
T10706 |
CCI-006
|
Mitochondrial Metabolism | Metabolism |
CCI-006 是一种 MLL 重排白血病细胞的选择性抑制剂和化学增敏剂。 它能够抑制线粒体呼吸,造成 MLL-r 白血病细胞亚群中无法克服的线粒体去极化和促凋亡未折叠蛋白反应。 | |||
T77621 |
Z16078526
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p38 MAPK; Mitochondrial Metabolism | MAPK; Metabolism |
Z16078526 enhances thermogenesis in mice by inducing endogenous Ucp1 expression, promoting p38 MAPK phosphorylation, and stimulating lipolysis in primary mouse brown adipocytes. Additionally, it activates thermogenic gene expression and mitochondrial activity, specifically uncoupled respiration, in these cells. | |||
T7486 |
Imeglimin hydrochloride
EMD 387008 hydrochloride,(6R)-1,6-二氢-N2,N2,6-三甲基-1,3,5-三嗪-2,4-二胺盐酸盐 |
Reactive Oxygen Species; Mitochondrial Metabolism | Immunology/Inflammation; Metabolism; NF-κB |
Imeglimin hydrochloride (EMD 387008 hydrochloride) 是一种口服降糖剂。Imeglimin 可改善胰岛素敏感性,能够抑制活性氧的产生、增加线粒体 DNA、改善线粒体功能。 | |||
T9232 |
Mitochondrial fusion promoter M1
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Mitochondrial Metabolism | Metabolism |
Mitochondrial fusion promoter M1 是一种线粒体动态调节剂,能够保持线粒体功能并促进细胞呼吸,减轻心肌缺血/再灌注大鼠的心脏损伤和大脑损伤。 | |||
T9768L |
Ninerafaxstat trihydrochloride
Ninerafaxstat trihydrochloride(2254741-41-6 Free base) |
Others | Others |
Ninerafaxstat trihydrochloride 将细胞代谢由脂肪酸氧化转变为葡萄糖氧化。 Ninerafaxstat trihydrochloride 改善整体线粒体呼吸并减少脂肪酸氧化,从而抑制癌细胞的增殖和生长。 | |||
T14346 |
Aumitin
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Others; Autophagy | Autophagy; Others |
Aumitin 是一种基于二氨基嘧啶的自噬抑制剂,以剂量依赖性抑制饥饿和雷帕霉素诱导的自噬,IC50分别为 0.12 μM 和 0.24 μM。它通过靶向复合物 I 抑制线粒体呼吸。 | |||
T36141 |
Boscalid
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Mitochondrial Metabolism | Metabolism |
Boscalid 是一种广谱羧酰胺类杀菌剂,通过与线粒体复合物 II/琥珀酸脱氢酶的泛醌位点结合来抑制真菌呼吸。 | |||
T77577 |
SLU-PP-332
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Estrogen/progestogen Receptor | Endocrinology/Hormones |
SLU-PP-332 是一种泛雌激素受体相关受体 (ERR) 激动剂,其对 ERRα, ERRβ 以及 ERRγ 具有很高的亲和力,EC50 值分别为 98、230 以及 430 nM。SLUPP-332 可增强骨骼肌细胞系的线粒体功能和细胞呼吸,增加 IIa 型氧化骨骼肌纤维并增强了运动耐力。SLU-PP-332 具有研究代谢性疾病以及肌肉功能改善的潜力,可能用于改善代谢紊乱和衰老。 | |||
T68508 | Ametoctradin | ||
Ametoctradin is a new Oomycete-specific fungicide and a potent Qo site inhibitor of the mitochondrial respiration complex III. | |||
T27537 |
Hexafluoro
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Hexafluoro is an inhibitor of DRP1 phosphorylation. Honokiol DCA stimulates a phenotype suggestive of respiration through mitochondrial normalization and demonstrates activity in Vemurafenib-resistant melanoma in vivo. | |||
T37913 | Picoxystrobin | ||
Picoxystrobin, a prominent primary strobilurin fungicide, is extensively utilized for efficient plant disease management. By obstructing electron transfer at the Qo center of cytochrome b and c1, picoxystrobin effectively halts mitochondrial respiration[1]. | |||
T26395 |
6-Benzylthioinosine
6-BT,6Benzylthioinosine,6-Bn-thioinosine |
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6-Benzylthioinosine, a broad-spectrum metabolic inhibitor, inhibits glucose uptake, decreases glycolysis and ATP concentration with minimal changes in ROS and mitochondrial respiration. | |||
T27551 |
Honokiol DCA
Honokiol Bis-Dichloroacetate |
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Honokiol DCA is an inhibitor of DRP1 phosphorylation. Honokiol DCA stimulates a phenotype suggestive of respiration through mitochondrial normalization and demonstrating activity in Vemurafenib-resistant melanoma in vivo. | |||
T13773 |
Mito-apocynin (C11)
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Others | Others |
Mito-apocynin (C11)是一种线粒体靶向抗氧化剂,通过靶向和中和细胞呼吸过程中产生的活性氧(ROS)发挥作用。三苯基溴化鏻已被发现能有效预防线粒体功能障碍,线粒体功能障碍是衰老过程和各种疾病的主要原因。它具有抗炎、抗凋亡和抗氧化活性。 | |||
T73600 |
Cefaloglycin
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Cefaloglycin(Cephaloglycin)是一种β-内酰胺类(β-lactam)口服活性头孢菌素类抗生素,具有肾毒性和抗菌活性。该药物对革兰氏阳性球菌(除肠球菌外)有效,同时对线粒体底物摄取及呼吸具有毒性。 | |||
T63538 |
8-Azido-ADP disodium
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8-Azido-ADP (disodium) 是一种线粒体腺嘌呤核苷酸易位的共价结合抑制剂,对ADP 诱导的线粒体呼吸的 4 到 3 正常转变表现出抑制作用。在光依赖反应中,8-Azido-ADP (disodium) 不可逆的抑制腺嘌呤核苷酸交换。 | |||
T35785 |
N-Oleoyl Leucine
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N-Oleoyl leucine is an N-acyl amide generated by PM20D1 that uncouples mitochondrial respiration independent of uncoupling protein 1 (UCP1) in vitro. N-Oleoyl leucine (25 mg/kg, i.p.) decreases body weight and food intake, preferentially decreasing fat mass in a diet-induced obesity mouse model. It improves glucose homeostasis in a fasting glucose tolerance test and increases VO2 while slightly decreasing overall locomotor activity. | |||
T36064 |
N-Oleoyl Glutamine
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N-Oleoyl glutamine is an endogenous N-acyl amine.1,2It is both formed and degraded by peptidase M20 domain-containing 1 (PM20D1), a factor secreted by thermogenic adipose cells. N-Oleoyl glutamine (50 μM) induces mitochondrial uncoupling to increase respiration in C2C12 cells by 64%.3It inhibits capsaicin-induced calcium flux in HEK293A cells co-transfected with transient receptor potential vanilloid 1 (TRPV1) and red fluorescent protein (RFP).2N-Oleoyl glutamine (100 mg/kg) reduces the number o... | |||
T79636 |
PKM2-IN-4
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PKM2-IN-4 (compound 5C)为PKM2的选择性抑制剂,具有0.35 μM的半抑制浓度(IC50),能够调控丙酮酸依赖的呼吸作用,并诱导线粒体H202的产生和电子传递系统的偶联效应。 | |||
T63637 | ROCK-IN-4 | ||
ROCK-IN-4 是 ROCK 的有效抑制剂,可维持 NO 释放能力。ROCK-IN-4 能够可逆地解聚 F-肌动蛋白,并阻碍人小梁网 (HTM) 细胞的线粒体呼吸。ROCK-IN-4 能够用于研究青光眼或高眼压。 | |||
T37498 |
Antimycin A4
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Antimycin A4 is an active component of the antimycin A antibiotic complex that is more polar than antimycin A1 , antimycin A2 , and antimycin A3 . Antimycin A4 inhibits ATP-citrate lyase with a Ki value of 64.8 μM. The antimycin A complex is a mixture of antimycins A1, A2, A3, and A4 that demonstrates antifungal, insecticidal, nematocidal, and piscicidal properties. It blocks mitochondrial respiration and can deplete cellular levels of ATP via inhibition of complex III of the mitochondrial elect... | |||
T37355 |
CAY10703
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Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria. Inhibition of PDHK shifts cell metabolism from glycolysis to mitochondrial glucose oxidation, an effect that has relevance to cancer, type 2 diabetes, and other diseases. CAY10703 is a DCA trimer that is at least 10-fold more cytotoxic against leukemia cell lines than DCA. It is approximately 3-fold less cytotoxic than DCA against perip... | |||
T37692 |
Piericidin B
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Piericidin B is a bacterial metabolite that has been found inS. mobaraensisand has insecticidal and antimicrobial activities.1,2,3It inhibits NADH oxidase activity in isolated bovine heart mitochondria and inhibits respiration in isolated rat liver mitochondria and isolated cockroach (P. americana) muscle mitochondria.2,3Topical application of piericidin B (4 μg/insect) induces mortality in 87.5% of houseflies (M. domestica).1It induces 93.3, 100, and 100% mortality in rice stem borer (C. simple... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN6891 |
1-Hexanol
hexan-1-ol,正己醇 |
Others | Others |
1-Hexanol (hexan-1-ol) 是一种伯醇,是一种表面活性剂,通过非质子机制解偶联线粒体呼吸,可用于增强工业过程中的界面性能。 | |||
T4838 |
(S)-Malic acid
L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid,L-苹果酸 |
Others; Endogenous Metabolite | Metabolism; Others |
(S)-Malic acid ((S)-2-Hydroxysuccinic acid) 是天然存在的二羧酸,是水果酸甜味的来源,常用作食品添加剂。 | |||
TN6608 |
Cyanidin-3-O-arabinoside chloride
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Cyanidin-3-O-arabinoside chloride has antioxidant activity. It reduces the peroxynitrite-induced suppression of mitochondrial respiration, DNA damage, PARS activation and vascular dysfunction in HUVECs. |