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Cat. No.	Product Name	Target	Signaling Pathways
T9970	mGluR3 modulator-1 1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile,1-乙基-3-(1,4-氧杂氮杂环己-4-基)-5,6,7,8-四氢异喹啉-4-甲腈	GluR	Neuroscience
	mGluR3 modulator-1 (1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile) 是 mGluR3 的正变构调节剂，可用于治疗帕金森病的研究。
T15090	Decoglurant RO4995819	GluR	Neuroscience
	Decoglurant (RO4995819) 是 mGluR2和 mGluR3的负变构调制器，有抗抑郁作用。
T3479	(RS)-MCPG alpha-MCPG,(±)-MCPG	GluR	Neuroscience
	(RS)-MCPG ((±)-MCPG) 是一种竞争性和选择性 I/II 组代谢型谷氨酸受体 (mGluR) 拮抗剂，可阻断 TBS 诱导的幼年和新生大鼠海马神经元的转变。
T6022	LY404039 pomaglumetad	Glucocorticoid Receptor; GluR	Endocrinology/Hormones; Neuroscience
	LY404039 (pomaglumetad) 是可口服的mGluR2和mGluR3选择性激动剂，有抗精神病和抗焦虑的作用。它对重组人mGluR2和mGluR3的Ki 分别为 149 和 92 nM，比对其他受体/转运蛋白的抑制性高 100 倍以上。
T13318	VU0650786	GluR	Neuroscience
	VU0650786 是能透过中枢神经系统的，选择性谷氨酸受体亚型 3 的一种负变构调节剂，IC50值为 392 nM，有抗抑郁和抗焦虑活性。
T22204	LY 2389575 hydrochloride	Beta Amyloid; GluR	Neuroscience
	LY2389575 hydrochloride 是一种 mGlu3 负变构调节剂 (NAM)，具有选择性和非竞争性，其IC50 值为 190 nM。LY2389575 hydrochloride 能诱导 Mrc1 水平升高，对β 淀粉样蛋白 (Aβ) 的毒性具有放大作用，可用于研究阿尔兹海默症。
T23003	ML337 ML 337	GluR	Neuroscience
	ML337 是 mGlu3 的负变构调节剂，IC50 为 593 nM。
T23000	ML289 VU0463597,ML 289	GluR	Neuroscience
	ML289 (VU0463597)是一种高效、选择性的，可透过血脑屏障的 mGlu3 (IC50=0.66 μM) 负变构调节剂。ML289 的选择性是 mGlu2 的 15 倍，对 mGlu5 无活性。
T11906	LY 541850	GluR	Neuroscience
	LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expressed in non-neuronal cells.
T15807	LY2794193	SGLT	GPCR/G Protein
	LY2794193 is a highly effective and selective agonist of the mGlu3 receptor (hmGlu3 Ki=0.927 nM,EC50=0.47 nM; hmGlu2 Ki=412 nM,EC50=47.5 nM).
T15809	LY2812223	LIM Kinase	Cell Cycle/Checkpoint
	LY2812223 is a highly effective and functionally selective mGlu2 receptor agonist. It has a mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively).
T11911	LY3020371 hydrochloride	GluR	Neuroscience
	LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks cAMP formation with IC50 of 16.2 nM.
T38791	LY3020371
	LY3020371 is a highly potent and selective antagonist targeting the glutamate (mGlu) 2/3 receptor, showcasing excellent inhibition at Ki values of 5.26 nM and 2.50 nM for hmGluR2 and hmGluR3, respectively. With its remarkable affinity and specificity, LY3020371 serves as a valuable tool in depression research.

化合物

mGluR3 modulator-1

Cat.No: T9970

Synonym: 1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile,1-乙基-3-(1,4-氧杂氮杂环己-4-基)-5,6,7,8-四氢异喹啉-4-甲腈

Target: GluR

Cat.No: T15090

Synonym: RO4995819

Target: GluR

Cat.No: T3479

Synonym: alpha-MCPG,(±)-MCPG

Target: GluR

Cat.No: T6022

Synonym: pomaglumetad

Target: Glucocorticoid Receptor, GluR

Cat.No: T13318

Target: GluR

LY 2389575 hydrochloride

Cat.No: T22204

Target: Beta Amyloid, GluR

Cat.No: T23003

Synonym: ML 337

Target: GluR

Cat.No: T23000

Synonym: VU0463597,ML 289

Target: GluR

Cat.No: T11906

Target: GluR

Cat.No: T15807

Target: SGLT

Cat.No: T15809

Target: LIM Kinase

LY3020371 hydrochloride

Cat.No: T11911

Target: GluR

Cat.No: T38791

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