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Search Results for " lanosterol "

24

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T32558	Lanosteryl acetate Lanosterol acetate
	Lanosteryl acetate is a bioactive chemical.
T8490	Butoconazole 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole,布康唑	Antifungal	Microbiology/Virology
	Butoconazole (1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole) 是一种咪唑类抗真菌药物，可治疗白色念珠菌引起的阴道感染。它可通过抑制类固醇起抗菌作用。
T3934	Isavuconazonium sulfate	Antifungal	Microbiology/Virology
	Isavuconazonium sulfate 是一种口服活性抗真菌药，是活性三唑类抗真菌药物 Isavuconazole 的前药，可用于侵袭性曲霉菌病和毛霉菌病。
T7866	Difenoconazole	Others; Antifungal	Microbiology/Virology; Others
	Difenoconazole 是一种广谱三唑类杀菌剂，通过抑制羊毛甾醇的细胞色素 P450 依赖性 14α-去甲基化来抑制麦角甾醇的生物合成，从而导致真菌细胞膜的破坏和细胞死亡。
T5966	Hexaconazole 己唑醇,(-)-Hexaconazol	Reactive Oxygen Species; Antifungal	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Hexaconazole ((-)-Hexaconazol) 是一种广谱三唑类杀菌剂，通过抑制羊毛甾醇的细胞色素 P450 依赖性 14α-去甲基化来抑制麦角甾醇的生物合成，从而导致真菌细胞膜的破坏和细胞死亡。
T1438	Butoconazole nitrate RS 35887,硝酸布康唑	Estrogen/progestogen Receptor; Antifungal	Endocrinology/Hormones; Microbiology/Virology
	Butoconazole nitrate (RS 35887) 是一种咪唑类抗真菌药物，可治疗由白色念珠菌引起的阴道感染。它可通过抑制类固醇合成起到抗菌作用。
T4039	BIBB 515	Others	Others
	BIBB 515 是口服具有活力的 2,3-氧化角鲨烯环化酶选择性抑制剂，在大鼠和小鼠中的 ED50值分别为 0.2-0.5 mg/kg 和 0.36-33.3 mg/kg (1-5 小时)。它主要利用抑制低密度脂蛋白的产生，从而发挥降脂作用。
T1187	Bifonazole 联苯苄唑,Bay H-4502	P450; Antibiotic; Antifungal	Metabolism; Microbiology/Virology
	Bifonazole (Bay H-4502) 是咪唑类抗真菌剂。
T1290	Oxiconazole nitrate 硝酸奥昔康唑,Ro 13-8996	Others; Antibiotic; Antifection; Antifungal	Microbiology/Virology; Others
	Oxiconazole nitrate (Ro 13-8996) 是广谱抗真菌药物，抑制T. tonsurans 和T.rubrum 的生长，MIC90值分别为 0.25 和 0.5 μg/mL。
T25127	Azalanstat RS-21607,RS 21607,RS21607
	Azalanstat is a lanosterol 14 alpha-demethylase inhibitor. The enzyme catalyzes the first step in the conversion of lanosterol to cholesterol in mammals.
T32095	Holothurinogenin Nobilisidenol A
	Holothurinogenin, as a lanosterol derivative, has toxic to nerve tissue.
T25625	Lanomycin
	Lanomycin, isolated from Pycnidiophora dispersa, inhibits lanosterol 14alpha-demethylase.
T69167	Buthiobate
	Buthiobate is a fungicide which inhibits lanosterol 14 alpha-demethylation catalyzed by a cytochrome P-450.
T71536	Mdl 28815
	Mdl 28815 is a potent inhibitor of 2,3-oxidosqualene cycloartenol & lanosterol cyclases.
T64029	Antifungal agent 42
	Antifungal agent 42 是一种抗真菌剂，对生物膜形成具有抑制作用。Antifungal agent 42 能够抑制 C.alb.的 lanosterol 14α-demethylase (CYP51)。
T70661	Azalanstat mesylate
	Azalanstat mesylate is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor. Azalanstat mesylate has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster liver, by inhibiting the cytochrome P450 enzyme lanosterol 14 alpha-demethylase. When administered orally to hamsters fed regular chow, RS-21607 (50 mg/kg/day) lowered serum cholesterol in a dose-dependent manner (ED50 = 62 mg/kg) in a period of 1 week. It preferentially...
T26191	SK&F 104976 SK&F104976,Skf104976,Skf 104976,SK&F-104976,Skf-104976
	SK&F 104976 is a 32-carboxylic acid derivative of lanosterol. It was found to be a potent lanosterol 14 alpha-demethylase (14 alpha DM) inhibitor.
T68998	Parconazole Free Base
	Parconazole Free Base is used in veterinary as an oral fungicide with a broad-spectrum activity against dermatophytes, yeasts, and others fungi. This compound does not have any antibacterial effect. The mechanism of action involves inhibition of the fungal cytochrome P450 dependent 14alpha-dimethylation of lanosterol to ergosterol.
T26424	A 60586 A60586,A-60586
	A 60586, a non-azole inhibitor of ergosterol biosynthesis, inhibits lanosterol 14alpha-demethylase and displays in-vitro antifungal activity.
T63285	Antifungal agent 40
	Antifungal agent 40 是抗真菌剂，能够延伸到 C.alb.CYP51 的狭窄疏水口袋 II 中，可抑制 lanosterol 14α-demethylase (CYP51) 的活性，对生物膜的形成具有抑制作用。
T70158	Quilseconazole besylate
	Quilseconazole besylate, also known as VT-1129 besylate, is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor.
T70660	Azalanstat HCl
	Azalanstat HCl is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor. Azalanstat HCl has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster liver, by inhibiting the cytochrome P450 enzyme lanosterol 14 alpha-demethylase. When administered orally to hamsters fed regular chow, RS-21607 (50 mg/kg/day) lowered serum cholesterol in a dose-dependent manner (ED50 = 62 mg/kg) in a period of 1 week. It preferentially lowered l...
T64105	Voriconazole camphorsulfonate
	Voriconazole (UK-109496) camphorsulfonate 是一种二代广谱的三唑类抗真菌 (antifungal) 化合物，对真菌麦角甾醇的生物合成表现出抑制作用。Voriconazole camphorsulfonate 能够抑制由真菌细胞色素 P450 酶介导的 14-α-羊毛甾醇去甲基化作用，表现出抗真菌效果。
T79550	Antifungal agent 68
	Antifungalagent 68（compound 10）是抗真菌剂，针对念珠菌和格特隐球菌。它通过抑制麦角甾醇的生物合成发挥作用，靶向羊毛甾醇 14α-去甲基酶（CYP51）。Antifungalagent 68的咪唑环能与CYP51的血红素基团发生相互作用。

化合物

Lanosteryl acetate

Cat.No: T32558

Synonym: Lanosterol acetate

Cat.No: T8490

Synonym: 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole,布康唑

Target: Antifungal

Isavuconazonium sulfate

Cat.No: T3934

Target: Antifungal

Cat.No: T7866

Target: Others, Antifungal

Cat.No: T5966

Synonym: 己唑醇,(-)-Hexaconazol

Target: Reactive Oxygen Species, Antifungal

Butoconazole nitrate

Cat.No: T1438

Synonym: RS 35887,硝酸布康唑

Target: Estrogen/progestogen Receptor, Antifungal

Cat.No: T4039

Target: Others

Cat.No: T1187

Synonym: 联苯苄唑,Bay H-4502

Target: P450, Antibiotic, Antifungal

Oxiconazole nitrate

Cat.No: T1290

Synonym: 硝酸奥昔康唑,Ro 13-8996

Target: Others, Antibiotic, Antifection, Antifungal

Cat.No: T25127

Synonym: RS-21607,RS 21607,RS21607

Holothurinogenin

Cat.No: T32095

Synonym: Nobilisidenol A

Cat.No: T25625

Cat.No: T69167

Cat.No: T71536

Antifungal agent 42

Cat.No: T64029

Azalanstat mesylate

Cat.No: T70661

Cat.No: T26191

Synonym: SK&F104976,Skf104976,Skf 104976,SK&F-104976,Skf-104976

Parconazole Free Base

Cat.No: T68998

Cat.No: T26424

Synonym: A60586,A-60586

Antifungal agent 40

Cat.No: T63285

Quilseconazole besylate

Cat.No: T70158

Cat.No: T70660

Voriconazole camphorsulfonate

Cat.No: T64105

Antifungal agent 68

Cat.No: T79550

Cat. No.	Product Name	Target	Signaling Pathways
T4970	LANOSTEROL 羊毛甾醇,3β-Hydroxy-8,24-lanostadiene,8,24-Lanostadien-3β-ol	Endogenous Metabolite	Metabolism
	Lanosterol (3β-Hydroxy-8,24-lanostadiene) 是胆固醇合成的中间产物，能够诱导胆固醇合成的速率控制酶 HMG-CoA 还原酶的泛素化和降解。Lanosterol 可以抑制神经退行性疾病相关错误折叠蛋白的聚集和细胞毒性。
T1011	Itraconazole 伊曲康唑,R51211	P450; Hedgehog/Smoothened; Antibiotic; Autophagy; Antifungal	Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Stem Cells
	Itraconazole (R51211) 是三唑类抗真菌药，也是口服活性的Hedgehog 信号通路拮抗剂，IC50约为 800 nM。它也是 oxysterol-binding protein 抑制剂。它抑制羊毛甾醇 14α-脱甲基酶，从而抑制羊毛甾醇向麦角固醇的氧化转化。它有抗癌和抗血管作用。
TN6736	Dihydrolanosterol 24,25-Dihydrolanosterol,Lanostenol,二氢羊毛甾醇	Others	Others
	Dihydrolanosterol (24,25-Dihydrolanosterol) 是一种 CYP51 的底物，能够阻碍胆固醇的合成。
T41052	24,25-Dihydrolanosterol Lanostenol,二氢羊毛甾醇
	24,25-Dihydrolanosterol (Lanostenol) is a chemical compound found in the seeds of the red pepper (Capsicum annuum).

天然产物

Cat.No: T4970

Synonym: 羊毛甾醇,3β-Hydroxy-8,24-lanostadiene,8,24-Lanostadien-3β-ol

Target: Endogenous Metabolite

Cat.No: T1011

Synonym: 伊曲康唑,R51211

Target: P450, Hedgehog/Smoothened, Antibiotic, Autophagy, Antifungal

Dihydrolanosterol

Cat.No: TN6736

Synonym: 24,25-Dihydrolanosterol,Lanostenol,二氢羊毛甾醇

Target: Others

24,25-Dihydrolanosterol

Cat.No: T41052

Synonym: Lanostenol,二氢羊毛甾醇

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