2
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21955 |
GQ-16
|
PPAR | DNA Damage/DNA Repair; Metabolism |
GQ-16 是 PPARγ 的部分激动剂,Ki 为 160 nM。 GQ-16 可减少脂肪生成作用并促进胰岛素敏化而不会增加体重。 | |||
T72947 |
JBSNF-000028
JBSNF-000028 free base |
Others | Others |
JBSNF-000028 是一种具有口服活性和有效性的烟酰胺 N-甲基转移酶 (NNMT) 抑制剂,对人 NNMT (hNNMT)、猴 NNMT (mkNNMT) 和小鼠 NNMT (mNNMT) 具有抑制作用, IC50 分别为 0.033 μM、0.19 μM 和 0.21 μM。JBSNF-000028 可驱动胰岛素敏化、葡萄糖调节和体重减,可用于研究代谢紊乱。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN4584 |
Morolic acid
|
IL Receptor; COX; HIV Protease | Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol and triglycerides, in part mediated by inhibition of 11β-HSD 1. Moro | |||
TN4585 |
Moronic acid
|
HIV Protease; Antifection; HSV | Microbiology/Virology; Proteases/Proteasome |
Moronic acid shows oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity. It also shows significant anti-HIV activity (EC(50) 186) and was modified to develop more potent anti-AIDS agents. Moronic acid is a new structural lead for anti-EBV drug development, can substantially reduce the numbers of EBV particles produced by the cells after lytic induction. Morolic and moronic acids have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an... |