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9
Cat. No. | Product Name | Target | Signaling Pathways |
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T5561 |
TLR7/8 agonist 1 dihydrochloride
TLR7/8 agonist-5d,二盐酸TLR7/8 agonist 1 |
TLR | Immunology/Inflammation |
TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) 是 toll 样受体TLR7/TLR8的双重激动剂。 | |||
T40971 |
Dehydroandrographolide succinate potassium sodium salt
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Dehydroandrographolide succinate (potassium sodium salt), derived from the herbal medicine Andrographis paniculata (Burm f) Nees, is a versatile compound highly utilized for the treatment of viral pneumonia and viral upper respiratory tract infections due to its potent immunostimulatory, anti-infective, and anti-inflammatory properties. | |||
T23785 |
Berlopentin
DA SP-5 |
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Berlopentin is splenopentin analog used to treat HIV-positive patients. It also has immunostimulatory properties. | |||
T38679 |
DODAP
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DODAP, an ionizable cationic lipid, serves as a vital component in liposome formation. Its applications encompass the capability to encapsulate siRNA, immunostimulatory chemotherapeutic agents for in vitro and in vivo delivery, among others. | |||
T40452 |
N-Acetylpsychosine
N-Acetylpsychosine,C2 Galactosylceramide (d18:1/2:0) |
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N-Acetylpsychosine, also known as α-galactosylated C2-ceramide (d18:1/2:0), exhibits immunostimulatory properties. This compound, N-Acetylpsychosine, holds potential as a valuable tool for studying the mechanisms of apoptosis and immune responses activated by dendritic cells (DCs). | |||
T78275 |
Ivuxolimab
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Ivuxolimab为针对OX40(亦称CD134;TNFRSF4)的激动型单克隆抗体。该抗体针对活化CD4+及CD8+T细胞表面的共刺激受体,具备抗肿瘤能力和潜在免疫刺激作用。 | |||
T74902 |
ODN 1018
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ODN 1018 (1018 ISS)为一种寡脱氧核苷酸,兼具TLR-9激动剂与合成免疫刺激序列的特性,广泛应用作疫苗佐剂。序列为5′-TGACTGTGAACGTTCGAGATGA-3′。 | |||
T82202 | H-Gly-Leu-Phe-OH | ||
H-Gly-Leu-Phe-OH (GLF)为源于α-乳白蛋白的三肽,具有免疫刺激性,能够抑制抗癌药物依托泊苷所引起的脱发、表皮增厚以及脂肪细胞层的变薄。 | |||
T74903 |
ODN 1668
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ODN 1668,一种B类CpG ODN(寡脱氧核苷酸),作为TLR-9激动剂,充当免疫刺激序列并可用作疫苗佐剂。序列为5’-tccatgacgttcctgatgct-3’。 | |||
T74914 |
ODN D-SL01
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ODN D-SL01,一种B类CpG ODN(寡脱氧核苷酸),作为TLR9激动剂,显示出显著的免疫刺激活性,并对多种脊椎动物物种表现出抗癌效应。序列为5'-T-C-G-C-G-A-C-G-T-T-C-G-C-C-C-G-A-C-G-T-T-C-G-G-T-A-3'。 | |||
T26688 |
Avadomide HCl
Avadomide hydrochloride,CC122, Avadomide HCl,CC-122,CC 122 HCl |
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Avadomide is an orally available pleiotropic pathway modulator with potential antineoplastic activity. CC-122 mimics an interferon response and has antitumor activity in DLBCL CC-122 binds Cereblon (CRBN) and promotes degradation of Ikaros and Aiolos in d |
Cat. No. | Product Name | Target | Signaling Pathways |
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T7974 |
Lynestrenol
|
Progesterone Receptor | Others |
Lynestrenol 是孕烷 X 受体 (PXR) 激动剂,能够作用于 hPXR(EC50:41 µM) 和 zfPXR(EC50:0.23 µM)。它是合成的孕酮,具有免疫刺激作用。 | |||
T4S1114 |
Dryocrassin ABBA
东北贯众素,Dryocrassin |
Influenza Virus; Antibacterial | Microbiology/Virology |
Dryocrassin ABBA (Dryocrassin) 是一种从苦参中提取的黄酮类天然产物,具有抗病毒和抗菌活性。它抑制树突状细胞的免疫刺激功能,延长同种异体皮肤移植成活率。 | |||
T14193 |
α-Galactosylceramide
KRN7000,α-GalCer |
Others | Others |
α-Galactosylceramide (KRN7000) 是一种具有抗肿瘤和免疫刺激作用的合成糖脂。它是一种高效的 NKT 细胞激动剂,可与 CD1d 有效结合。它与 CD1d 的复合物可与 NKT 细胞的 T 细胞抗原受体结合。 | |||
T7924 |
8-Bromoguanosine
|
Others | Others |
8-Bromoguanosine 是鸟苷的溴化衍生物。它是通过细胞内机制激活淋巴细胞发挥免疫刺激作用。 | |||
T3386 |
Kaempferitrin
Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside,山奈苷 |
cell cycle arrest; Glucokinase; IGF-1R | Cell Cycle/Checkpoint; Metabolism; Tyrosine Kinase/Adaptors |
Kaempferitrin (Lespenephryl) 是天然黄酮苷类化合物,具有缓解疼痛、抗糖尿病、消炎、抗肿瘤和化疗作用,可激活胰岛素信号传导。 | |||
T6S2099 |
Geraniin
|
Antioxidant; TNF | Apoptosis; oxidation-reduction |
Geraniin 是一种肿瘤坏死因子α释放抑制剂,其IC50值为 43 μM,具有抗肿瘤、抗炎和抗高血糖活性。 | |||
T82572 |
D-Glucosyl-β-1,1′-N-palmitoylsphingosine
C16 Glucosyl(β) Ceramide (d18:1/16:0) |
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D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) 是内源性Mincle配体,具免疫刺激活性。 | |||
TN6445 |
Cyclo(Gly-L-Pro)
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Cyclo(Gly-(L)-Pro) shows immunostimulatory properties. Cyclo(Gly-l-Pro) exhibits potent inhibition of TNF-α release with the IC50 values of 4.5 ug/mL, respectively, it also exhibits significant diminution of IL-1β and IL-6 mRNA-expression levels and NO pr | |||
T38838 |
QS-21
Stimulon,QS-21 |
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QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, which are dependent on caspase-1. |