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Cat. No.	Product Name	Target	Signaling Pathways
T9753	LEI110	Phospholipase	Metabolism
	LEI110 是一种有效的 Phospholipase A2, group XVI (PLA2G16) 抑制剂，Ki 值为 20 nM。 LEI110 是 HRASLS 硫醇水解酶家族（即 PLA2G16、HRASLS2、RARRES3 和 iNAT）的选择性泛抑制剂。
T15802	LY2183240	FAAH; Autophagy	Autophagy; Metabolism; Neuroscience
	LY2183240 是大麻素摄取阻滞剂。它是内源性大麻素降解酶脂肪酸酰胺水解酶的有效共价抑制剂。它抑制脂肪酸酰胺水解酶 (FAAH) 活性，IC50 为12.4 nM。它也抑制其他几种脑丝氨酸水解酶，对 MAG 脂肪酶、bh6 和 KIAA1363 的 IC50分别为 5.3、0.09 和 8.2 nM。
T10623	BSH-IN-1	Potassium Channel	Membrane transporter/Ion channel
	BSH-IN-1 是一种重组的肠道细菌胆汁盐水解酶 (BSHs) 的有效和共价抑制剂，对 B. longum BSH (革兰氏阳性) 和 B. theta BSH (革兰氏阴性菌) 的 IC50 分别为 108 和 427 nM。
T8997	WWL229	Others	Others
	WWL229 是羧酸酯酶3的选择性抑制剂 (IC50:1.94 µM) 。它可作用于培养脂肪细胞，提高脂质的储存，并减少基础脂肪分解。
T68626	JCP678
	JCP678 is an irreversible serine hydrolases inhibitor.
T37227	(±)8(9)-DiHET
	Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. The 8(S),9(R)-EET isomer is metabolized by platelet COX to form 8(S),9(R),11(R)-THETA, a trihydroxy fatty acid which may act as a renal vasoconstrictor.
T37242	(±)5(6)-DiHETE
	Eicosapentaenoic acid is an ω-3 polyunsaturated fatty acid that is abundant in marine organisms and fish oils. EPA is metabolized, in part, through cytochrome P450-catalyzed epoxidation followed by conversion to the vicinal diols by epoxide hydrolases. (±)5(6)-DiHETE is a possible metabolite produced from EPA following epoxidation of the α-5 double bond. The biological activity of (±)5(6)-DiHETE has not been documented.
T37243	(±)5(6)-DiHETE lactone
	Eicosapentaenoic acid is metabolized, in part, through cytochrome P450-catalyzed epoxidation followed by conversion to the vicinal diols by epoxide hydrolases. (±)5(6)-DiHETE is a possible metabolite produced from EPA following epoxidation of the α-5 double bond. (±)5(6)-DiHETE lactone is a 1,5 cyclic ester derived from (±)5(6)-DiHETE. While its biological activity is unknown, the selective capacity of (±)5(6)-DiHETE to form this lactone can be utilized to specifically quantify (±)5(6)-DiHETE in...
T74878	Enzyme-IN-1
	Enzyme-IN-1（compound 1）为基于肽的N端亲核试剂（Ntn）水解酶抑制剂，特别针对20S蛋白酶体的糜胰蛋白酶样活性（CT-L）进行抑制，可能展现出抗炎特性。
T76100	Maltose phosphorylase
	Maltose phosphorylase 是一种二聚酶，负责催化麦芽糖与无机磷酸盐转化成 β-D-葡萄糖-1-磷酸盐及葡萄糖。该酶归类于糖苷水解酶第65族。
T71525	AB05831
	AB05831, also known as 2-Acetamido-1,2-dideoxynojirimycin, is a highly potent and specific inhibitor of beta-hexosaminidase. N-Acetyl-3-hexosaminidase (HEX) is a member of lysosomal hydrolases, which catalyzes hydrolysis of terminal, non-reducing N-acetyl-\|3-D-glucosamine (GlcNAc) andN-acetyl-(3-D-galactosamine (GalNAc) residues in glycoproteins, gan-gliosides, and glycosaminoglycans (GAGs). HEX, released by chondrocytes into the extracellular compartment, promotes cartilage matrix degradation. ...
T76110	β-Glucosidase
	β-Glucosidase 是纤维素降解的限速酶。β-Glucosidase 是糖苷水解酶中的主要组份。β-Glucosidase 参与土壤中纤维素的降解，具有监测生物土壤质量的潜力。
T73317	JZP-MA-13
	JZP-MA-13是一种选择性α/β-水解酶结构域6 (ABHD6) 抑制剂，其IC50值为392 nM。该化合物对MAGL、ABHD12、FAAH或其它丝氨酸水解酶不表现出抑制作用。JZP-MA-13还被用作ABHD6在体内成像的正电子发射断层扫描(PET)配体。
T36838	(R)-Bromoenol lactone
	The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β exce...
T76123	Carboxylesterase
	Carboxylesterase (CESs), 即羧酸酯水解酶，广泛分布于自然界，常见于哺乳动物肝脏，常用于生化研究。Carboxylesterase 催化多种内源和外源底物的水解，包括酯、硫酯、氨基甲酸酯和酰胺，使羧酸酯水解成相应的醇和羧酸。
T38143	Elaidamide
	Elaidamide is a fatty acid amide that has been found in the cerebrospinal fluid of sleep-deprived cats.1 It inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM).2 Elaidamide also inhibits porcine pancreatic and human synovial phospholipase A2 (PLA2).3 In vivo, elaidamide (10 mg/animal) induces physiological sleep in rats.1References1. Cravatt, B.F., Prospero-Garcia, O., Siuzdak, G., et al. Chemical characterization of a family of brain lipids that induce sleep. Science 268(5216), 1506-150...
T37333	(±)11(12)-DiHET MaxSpec® Standard
	(±)-11(12)-DiHET is an oxylipin. 11(S),12(S)-DiHET and 11(R),12(R)-DiHET are vicinal diols formedviaenzymatic hydration of 11(12)-EET by cytosolic or soluble epoxide hydrolases in a non-stereoselective manner.1,2,3(±)11(12)-DiHET MaxSpec standard is a quantitative grade standard of (±)11(12)-DiHET that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a de...

化合物

Cat.No: T9753

Target: Phospholipase

Cat.No: T15802

Target: FAAH, Autophagy

Cat.No: T10623

Target: Potassium Channel

Cat.No: T8997

Target: Others

Cat.No: T68626

Cat.No: T37227

(±)5(6)-DiHETE

Cat.No: T37242

(±)5(6)-DiHETE lactone

Cat.No: T37243

Cat.No: T74878

Maltose phosphorylase

Cat.No: T76100

Cat.No: T71525

Cat.No: T76110

Cat.No: T73317

(R)-Bromoenol lactone

Cat.No: T36838

Carboxylesterase

Cat.No: T76123

Cat.No: T38143

(±)11(12)-DiHET MaxSpec® Standard

Cat.No: T37333

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