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Cat. No. | Product Name | Target | Signaling Pathways |
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T12492 |
Pivagabine
CXB-722,匹伐加宾 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Pivagabine (CXB-722) 是疏水性 4-氨基丁酸的衍生物,具有神经调节活性。它可穿透大鼠的血脑屏障,拮抗足部休克对大鼠脑中 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。 | |||
T3716 |
Rolapitant
罗拉吡坦,SCH619734,罗拉匹坦 |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Rolapitant (SCH619734) 是一种高效选择性具有口服活性的神经激肽 1 受体抑制剂,Ki 值为0.66 nM。 | |||
T8679 |
Epidermal Growth Factor
|
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Epidermal Growth Factor 与表皮生长因子受体 (EGFR) 结合并刺激细胞生长和增殖。它被批准用于治疗糖尿病足溃疡。 | |||
T0454L |
Florfenicol
SCH-25298,氟苯尼考,(-)-Florfenicol |
Antibacterial; Antibiotic | Microbiology/Virology |
Florfenicol (SCH-25298) 是一种常见得兽用抗生素,能用于研究牛呼吸疾病,在水产养殖业中可以用来控制鲶鱼肠道败血病,也可诱导鸡蛋早期胚胎死亡,LC50 值为 1.07 μg/g。 | |||
T61491 |
(R)-ND-336
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(R)-ND-336 is a highly potent and selective MMP-9 inhibitor, displaying a K i value of 19 nM. It also exhibits inhibitory activity against MMP-2 (K i = 127 nM) and MMP-14 (K i =119 nM). With its significant potential, (R)-ND-336 is being investigated in the field of diabetic foot ulcers (DFUs) research [1]. | |||
T70855 | Favipiravir sodium | ||
Favipiravir sodium is a selective inhibitor of viral RNA-dependent RNA polymerase with activity against many RNA viruses, influenza viruses, West Nile virus, yellow fever virus, foot-and-mouth disease virus as well as other flaviviruses, arenaviruses, bunyaviruses and alphaviruses. | |||
T68266 | BMS-751324 | ||
BMS-751324 是一种p38αMAPK 抑制剂。BMS-751324 含有氨基甲酰基亚甲基连接的前体,含有羟基苯基乙酸 (HPA) 衍生的酯和磷酸盐官能团。BMS-751324 在关节炎大鼠模型中有效抑制足部肿胀,并抑制 LPS 诱导的 TNFα 的生成。 | |||
T70960 |
Maprotiline-d3 hydrochloride
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Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selective for NET over the serotonin and dopamine transporters. Maprotiline also binds to the serotonin (5-HT) receptor subtype 5-HT2A, as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors. In vivo, maprotiline inhibits norepinephrine reuptake in r... | |||
T83704 |
A20FMDV2 TFA
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A20FMDV2是一种由口蹄疫病毒(FMDV)血清型O的VP1衣壳蛋白上的α-螺旋RGD细胞相互作用域组成的肽,能够结合到αVβ6整合素上。该化合物在表达人αVβ6的H357舌鳞状细胞癌细胞中抑制αVβ6整合素依赖的细胞粘附(IC50 = 1.2 µM)。与111indium-DTPA耦合时,A20FMDV2(20 MBq)可结合于在乳腺癌小鼠异种移植模型中内源性表达的αVβ6整合素,用于放射成像分析。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T73653 |
Pexiganan
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Pexiganan(MSI 78 free base),maganin 2 的合成类似物,是一种具有口服活性的广谱强效抗菌肽,主要用于研究糖尿病足溃疡等相关感染。 | |||
TN4505 | Masticadienolic acid | Others | Others |
Masticadienolic acid is a specific competitive inhibitor of secreted phospholipase A2, it not only protects the active site histidine from alkylation but also inhibits the action of secreted from pancreas, synovial fluid, and bee venom. Masticadienolic ac |